ID J7LA52_NOCAA Unreviewed; 607 AA.
AC J7LA52;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
GN OrderedLocusNames=B005_3196 {ECO:0000313|EMBL:AFR09526.1};
OS Nocardiopsis alba (strain ATCC BAA-2165 / BE74).
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Nocardiopsis.
OX NCBI_TaxID=1205910 {ECO:0000313|EMBL:AFR09526.1, ECO:0000313|Proteomes:UP000003779};
RN [1] {ECO:0000313|EMBL:AFR09526.1, ECO:0000313|Proteomes:UP000003779}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-2165 / BE74 {ECO:0000313|Proteomes:UP000003779};
RX PubMed=23105086; DOI=10.1128/JB.01522-12;
RA Qiao J., Chen L., Li Y., Wang J., Zhang W., Chen S.;
RT "Whole-Genome Sequence of Nocardiopsis alba Strain ATCC BAA-2165,
RT Associated with Honeybees.";
RL J. Bacteriol. 194:6358-6359(2012).
RN [2] {ECO:0000313|Proteomes:UP000003779}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-2165 / BE74 {ECO:0000313|Proteomes:UP000003779};
RA Qiao J., Chen L., Li Y., Wang J., Zhang W., Chen S.;
RT "Whole-genome sequence of Nocardiopsis alba strain ATCC BAA-2165 associated
RT with honeybees.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU365092};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU365092}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the lactate permease family.
CC {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
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DR EMBL; CP003788; AFR09526.1; -; Genomic_DNA.
DR RefSeq; WP_014911981.1; NC_018524.1.
DR AlphaFoldDB; J7LA52; -.
DR STRING; 1205910.B005_3196; -.
DR KEGG; nal:B005_3196; -.
DR PATRIC; fig|1205910.3.peg.3015; -.
DR eggNOG; COG1620; Bacteria.
DR HOGENOM; CLU_021628_4_1_11; -.
DR OrthoDB; 9761056at2; -.
DR Proteomes; UP000003779; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR003804; Lactate_perm.
DR PANTHER; PTHR30003:SF0; GLYCOLATE PERMEASE GLCA; 1.
DR PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR Pfam; PF02652; Lactate_perm; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU365092};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW Reference proteome {ECO:0000313|Proteomes:UP000003779};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365092};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365092};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT TRANSMEM 29..50
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 62..85
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 105..124
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 131..152
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 203..225
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 237..255
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 261..280
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 327..344
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 372..389
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 401..426
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 459..481
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 539..558
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 564..583
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
SQ SEQUENCE 607 AA; 63568 MW; DB2B9236837F813D CRC64;
MDNLALLSLL ALTPILVVGV LLVGFRLPAM YAMPAGYVVV VGIAVLFWGT EWRAVAASTV
QGLILAAGLL YIIFGALLLL ATLSGSGAIA TIRATFTDIT PDRRIQAIII GWLFGSFIEG
ASGFGTPAAV VAPLMLALGF PAMAAVMVGL VIQSTPVSFG AVGTPVLVGV SGGLEGSEAV
AERASVLGLT LPGYVDVIGL QTVLLHAVPG TLVPLFICCM LCGFYGGERR FSDGLGVWRF
ALFSAFAMTI PSVLYNHFLG VEFTSLLGGL TGLVIVVFAA RRGFLMPKRT WDFPPRERWL
DRWTGRLESG TGVEETAERG MGLFRAWAPY LLIVVVLVST RMITPLEEWL TGVKVGATDI
FGTSVGQTVE PLYSPGGAFI LVCLITYGLH RMRRREILAS WKVAGSQLAG AAVALLFAVP
LVRVFINTGP GFGDTSLESM PLTLAVGAAE LGGANWPLLA PWIGALGAFV AGSNTVSNLM
FSLFQFSTAE HIGVTPETVV ATQAVGGAAG NMITVHNVVA ASAVVGLAGR EGDLIRQTII
PMTYYVLLAG AVSQVFVYGF GPNVGTVALA LVLAALVGLV LFIRRRDAAP PRAATRGDGE
VPEGSRE
//
