ID J7LBZ7_NOCAA Unreviewed; 1036 AA.
AC J7LBZ7;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Alpha mannosidase, middle domain protein {ECO:0000313|EMBL:AFR10206.1};
GN OrderedLocusNames=B005_3452 {ECO:0000313|EMBL:AFR10206.1};
OS Nocardiopsis alba (strain ATCC BAA-2165 / BE74).
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Nocardiopsis.
OX NCBI_TaxID=1205910 {ECO:0000313|EMBL:AFR10206.1, ECO:0000313|Proteomes:UP000003779};
RN [1] {ECO:0000313|EMBL:AFR10206.1, ECO:0000313|Proteomes:UP000003779}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-2165 / BE74 {ECO:0000313|Proteomes:UP000003779};
RX PubMed=23105086; DOI=10.1128/JB.01522-12;
RA Qiao J., Chen L., Li Y., Wang J., Zhang W., Chen S.;
RT "Whole-Genome Sequence of Nocardiopsis alba Strain ATCC BAA-2165,
RT Associated with Honeybees.";
RL J. Bacteriol. 194:6358-6359(2012).
RN [2] {ECO:0000313|Proteomes:UP000003779}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-2165 / BE74 {ECO:0000313|Proteomes:UP000003779};
RA Qiao J., Chen L., Li Y., Wang J., Zhang W., Chen S.;
RT "Whole-genome sequence of Nocardiopsis alba strain ATCC BAA-2165 associated
RT with honeybees.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
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DR EMBL; CP003788; AFR10206.1; -; Genomic_DNA.
DR RefSeq; WP_014912660.1; NC_018524.1.
DR AlphaFoldDB; J7LBZ7; -.
DR STRING; 1205910.B005_3452; -.
DR KEGG; nal:B005_3452; -.
DR PATRIC; fig|1205910.3.peg.3263; -.
DR eggNOG; COG0383; Bacteria.
DR HOGENOM; CLU_003442_0_1_11; -.
DR OrthoDB; 9772207at2; -.
DR Proteomes; UP000003779; Chromosome.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR Gene3D; 2.60.40.2220; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR041147; GH38_C.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF17677; Glyco_hydro38C2; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000003779}.
FT DOMAIN 519..597
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1036 AA; 114766 MW; 6514F9E414D602CF CRC64;
MHDDRRLIEA RLERALRERV RPAVYGESIP LEVARWDVPG EPVPVAEGLA APYGPARVGD
AWGPAWGTTW FRLRGRVPRE WTGRRVEIVF DLGFDRAMPG FQCEGLVHRP DGTVVKGLNP
LNAWIPVGSP VEGEQDVEFH VEAAANPIIL GDPPFVPTDL GTAPGPRDEP LYRLARADLA
VFEEQVWELA LDLEVAGGLM LELDTGDPRR WELLRALGRT LDALDPQDVP GTAERAREVL
APALRSPASA SAHRVSAIGH AHIDSAWLWP LRETVRKVAR TSANVVGLTA DHPELVFAMS
QAQQWAWLKE HRPELFSRVL EEVAAGRFVP VGGMWVESDT NMPGSEALAR QFTFGKRFFR
DELGVDTREV WLPDSFGYSA ALPQLVRLSG SHWFLTQKIS WSRTNRFPHH TFWWEGLDGT
RVFTHFPPVD TYNSELTGAE LAHASRNFRD KGDATRSLVP FGHGDGGGGP TREMLGRAAR
LRDLEGSPRV TIEHPEEFFA RAHAEYTDAP VWWGELYLEF HRGTYTSQAA TKQGNRRSEH
LLREAELWST TAAVRAGADY PYERLERIWR TVLLHQFHDI LPGSSIAWVH REAAVAYREV
AEELTDVIAR AQTALVPEGS EAGDGVLFNP APHERDGVPA LGALPRSRVA RDDVPEALVA
PDEDGFVLDN GLLTVRVDRR GLVVSILDRS EGERGREVLA PGTTGNLLQL HQDVPNGWDA
WDVDEFYRNN VTDLTEADSV AVPAPEERAE AGLSSTAAAV RVRRSFGSSS VVQTLSLEPG
ARRLDVATEV DWHEREKLLK AAFPLDVHAR RSRSETQFGH IERPTHTNTS WDAAKFEICA
HRWVHVSEPG YGVAVLNDST YGHDVTHDAR PDGGTTTTVR LSLLRAPRFP DPLTDQGVHR
LRYALAPGAE VEDAVREGYR INLPVRELPG AAVVEPLVTV ADPGVVVEAV KLADDRSGDV
VVRLYEARGG RARTALTTGF PVRGVSAVNL LEEDYEEAPE LLSTALADEG EKDTGSPHRV
ELSLRPFQIL TLRLMR
//
