ID   J7MBW5_THEOR            Unreviewed;       682 AA.
AC   J7MBW5;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   22-FEB-2023, entry version 47.
DE   SubName: Full=DNA-directed RNA polymerase subunit alpha {ECO:0000313|EMBL:BAM38647.1};
GN   ORFNames=TOT_010000115 {ECO:0000313|EMBL:BAM38647.1};
OS   Theileria orientalis strain Shintoku.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Theileriidae; Theileria.
OX   NCBI_TaxID=869250 {ECO:0000313|EMBL:BAM38647.1, ECO:0000313|Proteomes:UP000003786};
RN   [1] {ECO:0000313|EMBL:BAM38647.1, ECO:0000313|Proteomes:UP000003786}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shintoku {ECO:0000313|EMBL:BAM38647.1,
RC   ECO:0000313|Proteomes:UP000003786};
RX   PubMed=22951932;
RA   Hayashida K., Hara Y., Abe T., Yamasaki C., Toyoda A., Kosuge T.,
RA   Suzuki Y., Sato Y., Kawashima S., Katayama T., Wakaguri H., Inoue N.,
RA   Homma K., Tada-Umezaki M., Yagi Y., Fujii Y., Habara T., Kanehisa M.,
RA   Watanabe H., Ito K., Gojobori T., Sugawara H., Imanishi T., Weir W.,
RA   Gardner M., Pain A., Shiels B., Hattori M., Nene V., Sugimoto C.;
RT   "Comparative genome analysis of three eukaryotic parasites with differing
RT   abilities to transform leukocytes reveals key mediators of Theileria-
RT   induced leukocyte transformation.";
RL   MBio 3:e00204-e00212(2012).
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DR   EMBL; AP011946; BAM38647.1; -; Genomic_DNA.
DR   RefSeq; XP_009688948.1; XM_009690653.1.
DR   AlphaFoldDB; J7MBW5; -.
DR   STRING; 869250.J7MBW5; -.
DR   EnsemblProtists; BAM38647; BAM38647; TOT_010000115.
DR   GeneID; 20713078; -.
DR   KEGG; tot:TOT_010000115; -.
DR   VEuPathDB; PiroplasmaDB:TOT_010000115; -.
DR   eggNOG; ENOG502RZXA; Eukaryota.
DR   OrthoDB; 208869at2759; -.
DR   Proteomes; UP000003786; Chromosome 1.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   Gene3D; 2.170.120.12; DNA-directed RNA polymerase, insert domain; 1.
DR   Gene3D; 3.30.1360.10; RNA polymerase, RBP11-like subunit; 1.
DR   InterPro; IPR011262; DNA-dir_RNA_pol_insert.
DR   InterPro; IPR011263; DNA-dir_RNA_pol_RpoA/D/Rpb3.
DR   InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
DR   InterPro; IPR036603; RBP11-like.
DR   InterPro; IPR036643; RNApol_insert_sf.
DR   Pfam; PF01000; RNA_pol_A_bac; 1.
DR   SMART; SM00662; RPOLD; 1.
DR   SUPFAM; SSF56553; Insert subdomain of RNA polymerase alpha subunit; 1.
DR   SUPFAM; SSF47794; Rad51 N-terminal domain-like; 1.
DR   SUPFAM; SSF55257; RBP11-like subunits of RNA polymerase; 1.
PE   4: Predicted;
KW   DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW   ECO:0000313|EMBL:BAM38647.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003786};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT   DOMAIN          264..497
FT                   /note="DNA-directed RNA polymerase RpoA/D/Rpb3-type"
FT                   /evidence="ECO:0000259|SMART:SM00662"
SQ   SEQUENCE   682 AA;  78105 MW;  77B607F83F8AC2BB CRC64;
     MKYDVIRIVF IIILSADLHS SALYLNHNFS GRLKHNFYSF RYLYITQPNI SHWKPSNIRE
     KYVNARETAG RASILSALNP KNAELHPESL SGVEPKITPE ELEKLKKKGL LDGDVKSWRN
     WHIVTRGRTL VFHDSVGEWD DIGTKMLPEA DKNLKITEPY ALRKPLKYWG FLRGIDDNIM
     SYPIMQEYYR DTYGKIDVHE HGGNNPLYNP LLFQPFYGMD KDRKGIGYHA PMLFKGWIGG
     DKNTPTKVKE ASDIIRIPDS GRLYQKFYMG PYPVTMGWTI GSLLKVMTLS RCPGHAIVAL
     KIHNMEKDTT VPGVHDDLLN IALNLKSVSL QTLEPGREAR VRTLIKGPAM LCAGALEWPP
     FVKVANPETY ITKLDEGAEL DLEIKIEWGR GFWIADTKGL YRTEEGADSL CHKRRNIKEV
     DEEDFYPTSC VFGGCRMIRL SVHKLMGQRW CAMTYTCPDP MDQLVVEIWT DVSTTPKDVL
     DFGLTEVIAW ITELKRQISH DVDFENEDEQ LKDVWEKIDK YGSLKHRQEL MGGPPVVPLH
     ESGIIPNLKE SDCHYLHPGD HKRIPQAPFS LPNDRPDRPS LDTLQWLAEQ LQSEEYEDES
     EINAKNYEKF VPKPVEDTFE NKDIDLLPVN AEMIASLRMS GFNTMSDIMG FTVEELSHYP
     GFTVDAARSI KSFLDENRTP NV
//