ID J7RL38_KAZNA Unreviewed; 1070 AA.
AC J7RL38;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 15 {ECO:0000256|ARBA:ARBA00019613};
GN Name=KNAG0D04780 {ECO:0000313|EMBL:CCK70218.1};
GN OrderedLocusNames=KNAG_0D04780 {ECO:0000313|EMBL:CCK70218.1};
OS Kazachstania naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797 / KCTC
OS 17520 / NBRC 10181 / NCYC 3082 / Yp74L-3) (Yeast) (Saccharomyces
OS naganishii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX NCBI_TaxID=1071383 {ECO:0000313|EMBL:CCK70218.1, ECO:0000313|Proteomes:UP000006310};
RN [1] {ECO:0000313|EMBL:CCK70218.1, ECO:0000313|Proteomes:UP000006310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520
RC / NBRC 10181 / NCYC 3082 {ECO:0000313|Proteomes:UP000006310};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
RN [2] {ECO:0000313|Proteomes:UP000006310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520
RC / NBRC 10181 / NCYC 3082 {ECO:0000313|Proteomes:UP000006310};
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Genome sequence of Kazachstania naganishii.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 15 family.
CC {ECO:0000256|ARBA:ARBA00009807}.
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DR EMBL; HE978317; CCK70218.1; -; Genomic_DNA.
DR AlphaFoldDB; J7RL38; -.
DR STRING; 1071383.J7RL38; -.
DR eggNOG; ENOG502QVXD; Eukaryota.
DR HOGENOM; CLU_009962_0_0_1; -.
DR OMA; RYQKYYE; -.
DR OrthoDB; 2729340at2759; -.
DR Proteomes; UP000006310; Chromosome 4.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd12191; gal11_coact; 1.
DR Gene3D; 1.10.287.2920; -; 1.
DR Gene3D; 1.10.246.20; Coactivator CBP, KIX domain; 1.
DR InterPro; IPR033789; Gal11_coact.
DR InterPro; IPR036529; KIX_dom_sf.
DR InterPro; IPR036546; MED15_KIX.
DR InterPro; IPR008626; Mediator_Med15_fun.
DR Pfam; PF18535; Gal11_ABD1; 1.
DR Pfam; PF16987; KIX_2; 1.
DR Pfam; PF05397; Med15_fungi; 1.
DR SUPFAM; SSF47040; Kix domain of CBP (creb binding protein); 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006310}.
FT DOMAIN 8..85
FT /note="Mediator complex subunit 15 KIX"
FT /evidence="ECO:0000259|Pfam:PF16987"
FT DOMAIN 184..264
FT /note="Gal11 coactivator"
FT /evidence="ECO:0000259|Pfam:PF18535"
FT REGION 131..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 993..1016
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1070 AA; 119319 MW; 093DF9158B4619CD CRC64;
MNVAPGIETL TNDERARNVT ELLQVLMDIN DINGGNNETA EKMKVHVKNF ESALYAKCSS
KKEYLDSMRE RVTAMKNTRD IRKKSSMNTA AAAATAKQQD IVLQQQQQQQ QQQQQQQQQQ
QRQFQNNFNN EMQADGIGKP GNNGNFVPNT VNMNSRMFLN QQAQARQQAA QQLKTRQQQQ
QQDQRHQLTP EQQILINQMK VAPIPRELLQ RIPKVPAGVN TWQQITELAQ QKRFSPQDMQ
IAKEVYKIHQ QLLYKSKMQQ QARARAQVQA QAQVQAQAQA QVQNQNQGPL QSQPQMQSQP
QAMNQKQGQQ QRPMNRDGQQ TVNVLNQISQ IFTPEEQRTL LHEAMEACKQ FQKTRYGANM
ADPDRQSFIR KYINQKALKK LQSMRMSQAA AVAANNGPIR QSIPDSRNAS ATNVVPPSAS
NFNNLSASGT STAMGSQVPQ LVPASQINSA NVPNDKTNAN AILLAQQQQQ QTPQPQKPAD
AVRQQKANSK PLLHYLQPTQ RDLETVRKIS AEATKISLRL TDLTNAISAQ EKEEIKRKLQ
LNQQLFAQVS NYAPQVYVFT KSEVFLKEVL QLRIFVKEIL EKCAKGIYVV KLDTVDKLVM
KYQKYWESMK LQLLRRQQLI QQQQTQPGGT PQQIERSNNG TAGAPDNAMM QQKRLQQIQQ
QMQNKQQWQL QQQQQQQQNM AAMNMNAFSP PASTNAPKSQ NNMPQFNAGQ LSGNAPDMKK
RKTSATPQLP HAAHATATPD FHTISPMAVG QTGTSPVKDA TGLHQRSKSS SKKLSPMNLN
NGVSLNANAL ASGNKAATPT SLNNVGPSPS LVGRTGTIPQ HSPTPSQSNA ATGVSAVAPS
PFKKEEDMLE SLNVRKAEVV SRFKHRQELF QNSPIDTFLS TLADTFGIKD ESMDPPVVKF
SQQVIDQVNG TGRKKITKAA QRVRDKDVVD VEINDSNKLI MRSKVAKEGR SYGIKLSSIS
DVFGQATGIH DYDMCVGLMT DFDKTGSGIG RKRKMDDSML GDEVSPSTGS LMGDSKRVKI
DSPDDMFVDD HIKMNGPRNM NTGGTTNADK SANIWNWGFW TPEMGAVENA
//
