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Database: UniProt
Entry: J7S4B7_KAZNA
LinkDB: J7S4B7_KAZNA
Original site: J7S4B7_KAZNA 
ID   J7S4B7_KAZNA            Unreviewed;       880 AA.
AC   J7S4B7;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   20-DEC-2017, entry version 23.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=KNAG0M02640 {ECO:0000313|EMBL:CCK73117.1};
GN   OrderedLocusNames=KNAG_0M02640 {ECO:0000313|EMBL:CCK73117.1};
OS   Kazachstania naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797 /
OS   CCRC 22969 / KCTC 17520 / NBRC 10181 / NCYC 3082) (Yeast)
OS   (Saccharomyces naganishii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX   NCBI_TaxID=1071383 {ECO:0000313|EMBL:CCK73117.1, ECO:0000313|Proteomes:UP000006310};
RN   [1] {ECO:0000313|EMBL:CCK73117.1, ECO:0000313|Proteomes:UP000006310}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520
RC   / NBRC 10181 / NCYC 3082 {ECO:0000313|Proteomes:UP000006310};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S.,
RA   Byrne K.P., Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type
RT   switching accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
RN   [2] {ECO:0000313|Proteomes:UP000006310}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520
RC   / NBRC 10181 / NCYC 3082 {ECO:0000313|Proteomes:UP000006310};
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S.,
RA   Byrne K.P., Wolfe K.H.;
RT   "Genome sequence of Kazachstania naganishii.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; HE978326; CCK73117.1; -; Genomic_DNA.
DR   EnsemblFungi; CCK73117; CCK73117; KNAG_0M02640.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000006310; Chromosome 13.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; IEA:EnsemblFungi.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:EnsemblFungi.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:EnsemblFungi.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0007035; P:vacuolar acidification; IEA:EnsemblFungi.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006310};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006310};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    460    484       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    505    522       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    582    600       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    612    634       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    675    694       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    781    800       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    820    838       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      116    143       {ECO:0000256|SAM:Coils}.
FT   COILED      319    339       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   880 AA;  100605 MW;  5AF01F23549F2E70 CRC64;
     MVKEEAIYRS AAMTYVQLYI PRETSREVVC LLGNLGLLMV RDLNSDVTEF QRGYVNQLRK
     LEVMMRSLQY LRETMDQHSE VNNWHLNDGT YTQNDVLIRN LETHSLDSIN EILGDIDIVE
     NRVKQLDHSL KDLQVRLNGL IETRYVMFKC SRFMEVNPGF VGRISRDYTE QHGLDADDFS
     FDNLGQASDH LSEEFSFDDP TTEPDSNSLR NENPTIPHHE HAEFDLLEQG LHNQFMTVGS
     IRRDKVDVLN RILFRLLRGN IYFQNFPIEQ PLLENNELVE KDCFLIFTHG ETLLTKVKKV
     VESLNGVVVP LDKNQSEFLK TLNDQISDLE QVSMTTEQAL HTELLVVNDQ FSMWDAIVKR
     EKAIYSTLNL FRAEAQGLVA EGWIPTSDLL DFSTSLKDFM EVLGSESSAV VTVIHTNKSP
     PTFHRTNKFT SAFQSIVDAY GIATYQEINP GLATIVTFPF MFAIMFGDAG HGFILFAVAL
     YMILRERTFD RMKRDEIFDM AYTGRYVLVL MGAFSIYTGI LYNDIFSKSM NLFKSGWEWP
     SGFKAGESIE AQKTSVYPLG LDFAWHGTEN GLIFSNSYKM KLSILMGFAH MTYSLMFSYV
     NYRNKRSMVE IIGNFIPSLL FMQSIFGYLS WAIIFKWSKD WNKDGKPAPG LLNMLINMFL
     APGKIDYELY PHQALLQKFL LLVALISVPW LLLYKPLVLR RMNNKATGRG YQSIHEQQAS
     EALLDTQRDS TDMEGTMVIT DFENSENGES TEFNFGDVMI HQVIHTIEFC LNCISHTASY
     LRLWALSLAH AQLSTVLWAM TIQNAFSSSN PGSPLAVAKV VFLFGMWFIL TVCILVCMEG
     TSAMLHALRL HWVEAMSKYF EGEGYAYEPF AFKTLAEGGE
//
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