ID J7S4H2_KAZNA Unreviewed; 637 AA.
AC J7S4H2;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Translation initiation factor eIF2B subunit delta {ECO:0000256|ARBA:ARBA00044147};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit delta {ECO:0000256|ARBA:ARBA00044356};
GN Name=KNAG0B01190 {ECO:0000313|EMBL:CCK68566.1};
GN OrderedLocusNames=KNAG_0B01190 {ECO:0000313|EMBL:CCK68566.1};
OS Kazachstania naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797 / KCTC
OS 17520 / NBRC 10181 / NCYC 3082 / Yp74L-3) (Yeast) (Saccharomyces
OS naganishii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX NCBI_TaxID=1071383 {ECO:0000313|EMBL:CCK68566.1, ECO:0000313|Proteomes:UP000006310};
RN [1] {ECO:0000313|EMBL:CCK68566.1, ECO:0000313|Proteomes:UP000006310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520
RC / NBRC 10181 / NCYC 3082 {ECO:0000313|Proteomes:UP000006310};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
RN [2] {ECO:0000313|Proteomes:UP000006310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520
RC / NBRC 10181 / NCYC 3082 {ECO:0000313|Proteomes:UP000006310};
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Genome sequence of Kazachstania naganishii.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC {ECO:0000256|ARBA:ARBA00007251, ECO:0000256|RuleBase:RU003814}.
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DR EMBL; HE978315; CCK68566.1; -; Genomic_DNA.
DR AlphaFoldDB; J7S4H2; -.
DR STRING; 1071383.J7S4H2; -.
DR eggNOG; KOG1467; Eukaryota.
DR HOGENOM; CLU_016218_3_4_1; -.
DR OMA; IPRCIAM; -.
DR OrthoDB; 169924at2759; -.
DR Proteomes; UP000006310; Chromosome 2.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 1.20.120.420; translation initiation factor eif-2b, domain 1; 1.
DR InterPro; IPR000649; IF-2B-related.
DR InterPro; IPR042529; IF_2B-like_C.
DR InterPro; IPR027363; M1Pi_N.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR10233; TRANSLATION INITIATION FACTOR EIF-2B; 1.
DR PANTHER; PTHR10233:SF14; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA; 1.
DR Pfam; PF01008; IF-2B; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000006310}.
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 637 AA; 70116 MW; C85DE1B8A3B014CC CRC64;
MSNEKDVKVE DQNSGSAAQP AAETASSEKK LSNKELKELK KREKAAKRSA QKQASGITIE
QQQLQAQAKR EKKKQQQHRE EQKREAKLKK IQNELNPSRK AKKTTLFSHL ETTEERRASI
LAISSAVTSP VASRITASGL MIPMVASVVS GSQVYTTSSF SNSGPTLKNE TAPKVQKSSP
AVSGQAVTVA GTASVPDHSS TQDIAKSLAT MSLESEDFGV VPGISSIVPH TLEESFENSQ
LVSSVKELLL NKDYIHPAIT LLTTNLAHYK IVGSIPRCIA MLEAFQIVIR DYQTPKGTTL
SRNLTNYLSH QIDILKKARP LSVTMGNAIR WIKQEISHID PSISDEVAKQ DLCEQIAQFA
REKIELADQL IIENASNHIE KSATIVVYGS SKVISDLILH NTLQLQKNIK VIVVDSRPLF
EGRSMANMLR RKGVDVMYSL ITSLDAVFDM GVDYVFLGAH SILSNGFLYS RVGTAMIAMS
AKRRNIPVLV CCESLKFSQR VQLDSVTFNE LADPNDLVSI DYDNPLERRG NTGTLLKQFL
KERETGRKKQ ESENKIKGKA SVSSSNNRNK VNGASAPSEG GEEKNILDSW HGLKSLNIVN
ILYDLTPPEY IKKVITEFGA LPPSSVPVIL REYKGST
//
