ID J7SAC9_KAZNA Unreviewed; 1051 AA.
AC J7SAC9;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=DNA mismatch repair protein MSH3 {ECO:0000256|ARBA:ARBA00019000};
DE AltName: Full=DNA mismatch repair protein msh3 {ECO:0000256|ARBA:ARBA00022151};
DE AltName: Full=MutS protein homolog 3 {ECO:0000256|ARBA:ARBA00029792};
GN Name=KNAG0I02660 {ECO:0000313|EMBL:CCK72051.1};
GN OrderedLocusNames=KNAG_0I02660 {ECO:0000313|EMBL:CCK72051.1};
OS Kazachstania naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797 / KCTC
OS 17520 / NBRC 10181 / NCYC 3082 / Yp74L-3) (Yeast) (Saccharomyces
OS naganishii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX NCBI_TaxID=1071383 {ECO:0000313|EMBL:CCK72051.1, ECO:0000313|Proteomes:UP000006310};
RN [1] {ECO:0000313|EMBL:CCK72051.1, ECO:0000313|Proteomes:UP000006310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520
RC / NBRC 10181 / NCYC 3082 {ECO:0000313|Proteomes:UP000006310};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
RN [2] {ECO:0000313|Proteomes:UP000006310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520
RC / NBRC 10181 / NCYC 3082 {ECO:0000313|Proteomes:UP000006310};
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Genome sequence of Kazachstania naganishii.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MSH3
CC subfamily. {ECO:0000256|ARBA:ARBA00007094}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HE978322; CCK72051.1; -; Genomic_DNA.
DR AlphaFoldDB; J7SAC9; -.
DR STRING; 1071383.J7SAC9; -.
DR eggNOG; KOG0218; Eukaryota.
DR HOGENOM; CLU_002472_0_0_1; -.
DR OMA; HIAPCEL; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000006310; Chromosome 9.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF122; DNA MISMATCH REPAIR PROTEIN MSH3; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006310}.
FT DOMAIN 890..906
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1051 AA; 119857 MW; 15784C2AA541ACC3 CRC64;
MAAQPTISRF FKAVKKEPKD TNQDPPDECS DIGKTAETSI SLSDEEDKYL GSIGDSRDGS
SERSIDTKVQ EEPAKRIVQQ TPNPPADGTG ASNVGSSLGK FALNGMDLPE TDTNKNANSN
SFAKRLNSIL NDDTTVEDKD VIDKRPSKML KVDDSKETKL TPLDEQVRSL KLQNMDKILL
VRVGYKYKCF AEDAIIVSSI LHIKLVQGKL TLDNSNPHDS QYKNFAYCSF PDVRLNINLE
RLIHENLKVG IVEQSETSSL KKQSENKSKS VFEREVTNVV SKATYGINVD KARSSKESPI
LGDTKSIWIL KVVPTSEQLS KYSLVSVNLN SGEVIFDEFS DTASSSEQLI TRVKYLDPIE
VILQCSEKHV NRCLKNAECQ ITEIKEEDNR HLDAFNELKV DVPVPETLKE LVAHLYHYLH
QYNNENILLI TDNYRPFTSK MFMLLDGNAM DALDIFSNEG KKGSLFWVLN HTRTPFGSRQ
LRNWVKRPLL NTTDIEDRLD AIECISEVIN DIFFESLNHL LKSIPDLSHT LNRITYGRTS
RREVYYFLKQ ICSLIDHFKL HQSYIENQIL LPDGKIPKRS KLLPKWFQEM YEYLKDSNIP
RILTMVNVAA VMEKDPEKQQ IGFLNLNNYD NPAKIIDIQR NIESIQDEMN VELNNIRKFL
KRPYLNYRDE VDYLIEVRNS QVKGLPDDWV KVNSTKSVSR FLTPKNTKLL QNLQYQKDLL
LQETRSEFLV FLQKIKAEYT SLNKLIQKIA NYDCILALAA TSCAINYVRP KFETNKGQFV
SIVKGRNAVI ESLDRNYVPN DSNMYTNEGK ITIITGPNMG GKSSYIRQVA LLIVMAQIGS
FVPAHSMELS LFDNIFTRIG ANDNLLQGQS TFMVEMSEIL HIIKRATPKS LLLLDEVGRG
TGTIDGRAIC YAILKYYLEL VDCPLILFTT HFPDIGKQLR DTYQKAIKNF YMDYVEEQKP
GESWQSVIFL YQLKEGLSED SYGLNVAKLA GIDSEIINSA YQVSRKMKNE ESESEKLLKL
VLGLRSIFQS SENKAESNGE QFRRLLEICD N
//
