ID   J8LNK7_SACAR            Unreviewed;       948 AA.
AC   J8LNK7;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=Mdr1p {ECO:0000313|EMBL:EJS43682.1};
GN   ORFNames=SU7_1257 {ECO:0000313|EMBL:EJS43682.1};
OS   Saccharomyces arboricola (strain H-6 / AS 2.3317 / CBS 10644) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=1160507 {ECO:0000313|EMBL:EJS43682.1, ECO:0000313|Proteomes:UP000006968};
RN   [1] {ECO:0000313|EMBL:EJS43682.1, ECO:0000313|Proteomes:UP000006968}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H-6 / AS 2.3317 / CBS 10644
RC   {ECO:0000313|Proteomes:UP000006968};
RX   PubMed=23368932; DOI=10.1186/1471-2164-14-69;
RA   Liti G., Nguyen Ba A.N., Blythe M., Mueller C.A., Bergstroem A.,
RA   Cubillos F.A., Dafhnis-Calas F., Khoshraftar S., Malla S., Mehta N.,
RA   Siow C.C., Warringer J., Moses A.M., Louis E.J., Nieduszynski C.A.;
RT   "High quality de novo sequencing and assembly of the Saccharomyces
RT   arboricolus genome.";
RL   BMC Genomics 14:69-69(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJS43682.1}.
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DR   EMBL; ALIE01000087; EJS43682.1; -; Genomic_DNA.
DR   AlphaFoldDB; J8LNK7; -.
DR   HOGENOM; CLU_003538_0_1_1; -.
DR   OrthoDB; 3034081at2759; -.
DR   Proteomes; UP000006968; Chromosome VII.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR   Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR004182; GRAM.
DR   InterPro; IPR000195; Rab-GAP-TBC_dom.
DR   InterPro; IPR035969; Rab-GAP_TBC_sf.
DR   PANTHER; PTHR47219:SF20; GTPASE ACTIVATING PROTEIN GYP2; 1.
DR   PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR   Pfam; PF02893; GRAM; 1.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00568; GRAM; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006968}.
FT   DOMAIN          244..432
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000259|PROSITE:PS50086"
FT   DOMAIN          638..673
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   REGION          866..888
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          915..948
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        866..883
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   948 AA;  109285 MW;  DB0D37AC72F0A07F CRC64;
     MSFFDSLRQK APFLDKLADS FTPTLTRDEK FRLKYKLPAS ENILDDTNAE VSYASSNEDG
     KGRLERANNK GRKTTYVFSG RLFLTPHFLV FRDAFDHSSC VLILNISTIK RVERSPSKSY
     EFALLVTLYS GAKVLIQFIG IRYRSEQFCN KLKSNLKENI PNAKNLPVFL ETSYSEFLIA
     KNILGKKDIT VPKAGLGQHF KYPGNPTMVK EKAKLRLWFD YFRENGRNLA IVQTLMFRKL
     IRIGIPNRMR GEIWELCSGA MYMRYANAGE YEKILSDNAS KTSQAIDEIE KDLKRSLPEY
     SAYQTEEGIQ RLRNVLTAYS WKNPDVGYCQ AMNIVVAGFL IFMSEEQAFW CLCNLCEIYV
     PGYYSKTMYG TLLDQKVFES FVEDRIPVLW EYIVQHDIQL SVVSLPWFLS LFFTSIPLEY
     AVRIMDIFFM NGCITLFQVA LAVLKINADD ILQANDDGMF IAIIKHYFQT LGQSAHPDSS
     DIKYREITKF QELLVTAFKE FSVITEEMVM QARHKYEKGI FQNIETFMKR TQLRHMPKTF
     NLSSDKLSNI YDMFYQSIET YKISMGTGSS NMGFEVFIQF LSKFCDSCRP CEKDKEPAFR
     KQKRNFLQRL FNNWDSAHIG ELTLNDVVTG LDKLLTVDLL QAINYFFSLY DTDDDGELHR
     EEVLQLSEGL LMLTEPWKSG TYVDLLTKKR IEDDIAESII KENGEETVTM NQIELPTGVT
     IDEEKYKAEQ AERYLKAASN FLQRSFEYAK AVNLAEEVNL IDLSDDEDEE KHNAKLKKLN
     SIKANVALDP THPKVIDLPT FRMIILADET YELFFSNTLR SSVHVDEHIN VNNKNKVLRS
     MFDGILADGK RVAEQVRRRV DSVATRNSIT SAESTPTTAA HSITTKEEKY DDLDDFTSEH
     QSEHEELLQS SWFEIEDATE SNAMQERPFE PLSVSPSDKK SNLIEFEA
//