ID J9B7X6_WUCBA Unreviewed; 544 AA.
AC J9B7X6;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Tetratricopeptide repeat protein 30 {ECO:0000256|RuleBase:RU367070};
DE Flags: Fragment;
GN ORFNames=WUBG_05949 {ECO:0000313|EMBL:EJW83140.1};
OS Wuchereria bancrofti.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX NCBI_TaxID=6293 {ECO:0000313|EMBL:EJW83140.1, ECO:0000313|Proteomes:UP000004810};
RN [1] {ECO:0000313|Proteomes:UP000004810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA {ECO:0000313|Proteomes:UP000004810};
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Hepburn T.,
RA Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M.,
RA Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "The Genome Sequence of Wuchereria bancrofti.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a
CC role in anterograde intraflagellar transport (IFT), the process by
CC which cilia precursors are transported from the base of the cilium to
CC the site of their incorporation at the tip.
CC {ECO:0000256|RuleBase:RU367070}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000256|ARBA:ARBA00004138, ECO:0000256|RuleBase:RU367070}.
CC -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family.
CC {ECO:0000256|ARBA:ARBA00009522, ECO:0000256|RuleBase:RU367070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJW83140.1}.
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DR EMBL; ADBV01002402; EJW83140.1; -; Genomic_DNA.
DR AlphaFoldDB; J9B7X6; -.
DR Proteomes; UP000004810; Unassembled WGS sequence.
DR GO; GO:0005879; C:axonemal microtubule; IEA:UniProtKB-UniRule.
DR GO; GO:0042073; P:intraciliary transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR039941; TT30.
DR PANTHER; PTHR20931:SF0; TETRATRICOPEPTIDE REPEAT PROTEIN 30; 1.
DR PANTHER; PTHR20931; UNCHARACTERIZED; 1.
DR Pfam; PF13432; TPR_16; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; TPR-like; 3.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW ECO:0000256|RuleBase:RU367070};
KW Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU367070};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794,
KW ECO:0000256|RuleBase:RU367070}; Coiled coil {ECO:0000256|SAM:Coils};
KW TPR repeat {ECO:0000256|RuleBase:RU367070}.
FT COILED 494..524
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 544
FT /evidence="ECO:0000313|EMBL:EJW83140.1"
SQ SEQUENCE 544 AA; 62623 MW; 41754BDF9F6FD0DE CRC64;
MPFAPIKDGE FTSTIYGMIQ ERRYENAIRA LQYELQRTPN SRAALSLLGY CYFYLQQFID
AAECYEQLVR LYSSYPEYRL YWAQSLYNAF MFPEASAVVS QIDEPQFAGQ VLKLESAIKY
REEDIVNARI LVEKYAMNDP DGDINLACLE YKEGNYEKAL ERFTTATHLH GYQPCLAYSI
ALCYYQMHNY SQALKFIADI IDQGVQNHPA ELSIGMATEG MEVSSVGNTR LLRETSLVEA
CNLKAAIEYN LKNLSAASEA LTDMPPRLEE ELDPVTLHNQ ALINMDTNPS DGFAKLQYLL
SQNPFPPETF SNLLLLYCKY EYYDLAADVL AENAHLTYKY LTQYLYDYFD AVITQQTAPM
DAYNKFEAIG NEQINELRRL TKRMNEIRDG NDEVIIQKTA KAYDDTMARY MPVLMSQAKI
YWDMNNYSQV EKIFRKSVEF CSENDIWKLN VAHTLFMQAN KFKEAAGFYE PNVKKNFDNM
LSITAIILAN LSVCYIMTNQ NEEAEELMKK VENEEEASAA TSNKTKFFHL CIINLVIGTL
YCSK
//
