ID   J9BAK2_WUCBA            Unreviewed;       567 AA.
AC   J9BAK2;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   RecName: Full=Glutamate synthase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=WUBG_04969 {ECO:0000313|EMBL:EJW84120.1};
OS   Wuchereria bancrofti.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX   NCBI_TaxID=6293 {ECO:0000313|EMBL:EJW84120.1, ECO:0000313|Proteomes:UP000004810};
RN   [1] {ECO:0000313|Proteomes:UP000004810}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA {ECO:0000313|Proteomes:UP000004810};
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Hepburn T.,
RA   Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M.,
RA   Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA   Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Wuchereria bancrofti.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJW84120.1}.
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DR   EMBL; ADBV01001803; EJW84120.1; -; Genomic_DNA.
DR   AlphaFoldDB; J9BAK2; -.
DR   Proteomes; UP000004810; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0016639; F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006537; P:glutamate biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR028261; DPD_II.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR006005; Glut_synth_ssu1.
DR   InterPro; IPR009051; Helical_ferredxn.
DR   NCBIfam; TIGR01317; GOGAT_sm_gam; 1.
DR   PANTHER; PTHR43100; GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN; 1.
DR   PANTHER; PTHR43100:SF1; GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN; 1.
DR   Pfam; PF14691; Fer4_20; 1.
DR   Pfam; PF07992; Pyr_redox_2; 2.
DR   PRINTS; PR00419; ADXRDTASE.
DR   SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR   SUPFAM; SSF51971; Nucleotide-binding domain; 2.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW   Glutamate biosynthesis {ECO:0000256|ARBA:ARBA00023164};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          91..189
FT                   /note="Dihydroprymidine dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF14691"
FT   DOMAIN          204..385
FT                   /note="FAD/NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF07992"
FT   DOMAIN          464..537
FT                   /note="FAD/NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF07992"
FT   REGION          26..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   567 AA;  63387 MW;  FA2C568B014EBF20 CRC64;
     MDMQIAVEPV RRKMIGSHHR TYPKLVRPED YTGFEETKDP QQEVEEEDEE EEPSDIGRYC
     RGFMKYRRQT VVYRPVEERI KVWNEITDYG AVRSNIRVQA ARCMDCGVPF CQGNTGCPLG
     NIIPKWNDYV FKQNWRQALE QLLQTNNFPE FTGRVCPAPC ESACCLAINS PPVTIKSIEC
     AIIDYAFLQG WMQPQKPNYS TGKRIAIIGS GPAGMAAAAQ LNKVGHAVVV YEKKNHAGGL
     LRLGLKLAEK YGIPTMKLDK YVVDRRVKLL EDEGVRFITN TEIGKDVSAD FLLKDNDAIL
     ISTGSTIPRD LLISNREAKG ICFAMEFLEK SQRIVAGEED AWEGLDAKGK RVIILGGGDT
     ATDCIATCTR LGAESVQALE IMSQPPDERY PDNPWPQWPI IFRTDYGHEE RKEITGDDPR
     LFGLSTKKFL VNVSGSGQKN LIGLLTIRVD WKRDENGAWI MSEIDGSEKE LPCDLCILAM
     GFTGPEKIVV EQLGIETDKR SNIFTAKDRY STSKCKIYAA GDCRRGQSLV VWAIHEGRQA
     ARQIDHDLMG KTTLAGPGGV VLAPIQN
//