ID   J9BJI7_WUCBA            Unreviewed;       498 AA.
AC   J9BJI7;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   28-JUN-2023, entry version 29.
DE   RecName: Full=C2 domain-containing protein {ECO:0000259|PROSITE:PS50004};
GN   ORFNames=WUBG_01538 {ECO:0000313|EMBL:EJW87550.1};
OS   Wuchereria bancrofti.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX   NCBI_TaxID=6293 {ECO:0000313|EMBL:EJW87550.1, ECO:0000313|Proteomes:UP000004810};
RN   [1] {ECO:0000313|Proteomes:UP000004810}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA {ECO:0000313|Proteomes:UP000004810};
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Hepburn T.,
RA   Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M.,
RA   Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA   Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Wuchereria bancrofti.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJW87550.1}.
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DR   EMBL; ADBV01000354; EJW87550.1; -; Genomic_DNA.
DR   AlphaFoldDB; J9BJI7; -.
DR   Proteomes; UP000004810; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd08374; C2F_Ferlin; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR037725; C2F_Ferlin.
DR   InterPro; IPR037721; Ferlin.
DR   InterPro; IPR032362; Ferlin_C.
DR   PANTHER; PTHR12546; FER-1-LIKE; 1.
DR   PANTHER; PTHR12546:SF33; SPERM VESICLE FUSION PROTEIN FER-1; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF16165; Ferlin_C; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   PROSITE; PS50004; C2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        460..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          157..304
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
SQ   SEQUENCE   498 AA;  57462 MW;  52BAE18907D1B11F CRC64;
     MIEMEVEIPI DKKLVVSVMD RHHNEIGHTV IDLENRLLTQ FRATVGLAQQ YITRGPLVWR
     DQLTPLSILK RHCMRMNYPA PELLMKGNDV GIMIAGVAVW LSDIESVPPN HTEILGRPLQ
     RMNLVPEHVE TRPLYSAINA DSECGKLEMF VDLFPHAMGS IPPPVNISPR RPHKFQLRVA
     VWSVRNVILT KRTMGKPAAD IYLKVFLNGS GKEEKTDIHY RSLDGYGSFN WRFVFDFDFD
     IWEKKIAMYT KKHLFSKKSS LLVDPILFVQ IWDNNKFRKD GYIGQLALDL LSFDEAQMDA
     DEMYNVDYAC ENRNRCNCCV KRCFCRCNSK RKERKKNIPL LRAPPYISGR VGQFSLFQQR
     TTYGWWPCVS ISLPDEQKLD FDTKIKKDDD FTAQKPYVTG AVELELTLLT SEEAKLDPVG
     KKRGKPNHSP YLPHPNRPRL DQFWCLSRAK ACCSFCWTSW GKQCVVIVIV ILISVVFIVS
     TVYKLPDIIT MKVFNIHS
//