ID J9BLG7_WUCBA Unreviewed; 1127 AA.
AC J9BLG7;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 08-NOV-2023, entry version 40.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN ORFNames=WUBG_00719 {ECO:0000313|EMBL:EJW88370.1};
OS Wuchereria bancrofti.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX NCBI_TaxID=6293 {ECO:0000313|EMBL:EJW88370.1, ECO:0000313|Proteomes:UP000004810};
RN [1] {ECO:0000313|Proteomes:UP000004810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA {ECO:0000313|Proteomes:UP000004810};
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Hepburn T.,
RA Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M.,
RA Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "The Genome Sequence of Wuchereria bancrofti.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJW88370.1}.
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DR EMBL; ADBV01000133; EJW88370.1; -; Genomic_DNA.
DR AlphaFoldDB; J9BLG7; -.
DR Proteomes; UP000004810; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF36; ANION EXCHANGE PROTEIN; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 513..534
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 543..561
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 598..623
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 630..648
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 717..734
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 754..772
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 802..821
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 841..858
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 902..922
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 928..952
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 156..434
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 485..980
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1127 AA; 126139 MW; 78E663E101229C0B CRC64;
MSNMKADGDG GDSSSKGSSV SASPSPPVTS SSLLSSKQQS TIVNVIPPPA SDDTQRAPLA
EPEQTEHHNL KHRGSIWDTY VEMSDVTERK RRMTRHFDSM DQAQHLADLA PGARVMFLLK
EPVELPALFT EMGELTRSGT VEEWRETARW VKFEEDVEEG GNRWSKPHVA TLSLHALFQL
RSCLMNGVII MDSEAKEFSE LIEEVLEHLV ASGQLEETEV DEVRNVLSKR HTHQYEQARG
TGNGNGSSQS GFLNAVRSIS DIGKTFSHGR NLGKLQEETI NEGTETSSKT PNLKLPEVGS
APKEITREGS HADVKGNLHF MKKLPSGAEA SNVLIGEVDF LTRYITAFVR LKNAATLGDL
TEVPVPTRFF FVLLGPTGNV AQYREIGRAI ATLMSDEIFH DVAYKARNSD DLLDGVDEFL
DQVTVLPPGE WDPNIRIEPP NKVPSQDKRK HGDELLLTKV PAPKKEVEEE DSHANDPALK
RTGHLFGGLI MDVKRKYPWY LSDFTDSLNL QCVATFCFMY FALLAPIVTF GGLLEEATHQ
RMAAMENLFG GAICGVIYHL FSGQPLTIIG STGPVLVFET IVFDLCASLN LDYLSFRFWI
HVWTAFILFV MVITDASALV SYITRFTEES FATLIAVIFI YEAIMKLVKI RTQLDIVEYN
KTNPHAICRC VGKDVSIVKA LGVIEKNNWK DIVGFDRCRR LYGTLEGDGC FILYDKFLMS
LVLMLGTFTL ATMFKRMRNT CYFPSRVRQI FSDFAVMIAI VIMTSVDMYV GISTPKLNVP
STFRPTWEGR GWYVPPFNGN PFWTVIVSFI PAILACILIF MDQQITTVIV NRKENKLKKG
YGYHLDLCVL AFLILVVGTL GLPIYVAATV LSINHVNSLK LESESRAPGE VAQFIGVREQ
RVTGIITFIF IGSSVLMTGV LSHIPMPVLY GVFLYMGIAA LGGIQLFDRI LLLLMPMKYQ
PDTIYIRHVP ISVIHKFTFC QVACLAVLWT VKSIKRTSIA FPIMLVVMVA VRKIMEKFFT
EKDLRYLDDK MPDFHLRKKE DMKRKKSVVE EFDIDLEENQ GTIHAVKTEA HLHIPTASGE
IIKIPLAAIQ EPSHNIHNMN ISNEVNRTGM WKHITLGANQ LSSTTAV
//
