ID   J9DF71_EDHAE            Unreviewed;       669 AA.
AC   J9DF71;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Mechanosensitive ion channel MscS domain-containing protein {ECO:0000259|Pfam:PF00924};
GN   ORFNames=EDEG_04040 {ECO:0000313|EMBL:EJW01255.1};
OS   Edhazardia aedis (strain USNM 41457) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Edhazardia.
OX   NCBI_TaxID=1003232 {ECO:0000313|EMBL:EJW01255.1, ECO:0000313|Proteomes:UP000003163};
RN   [1] {ECO:0000313|EMBL:EJW01255.1, ECO:0000313|Proteomes:UP000003163}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USNM 41457 {ECO:0000313|EMBL:EJW01255.1,
RC   ECO:0000313|Proteomes:UP000003163};
RA   Liu Z.J., Shi F.L., Lu J.Q., Li M., Wang Z.L.;
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000003163}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USNM 41457 {ECO:0000313|Proteomes:UP000003163};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Cuomo C.A., Sanscrainte N.D., Goldberg J.M., Heiman D., Young S., Zeng Q.,
RA   Becnel J.J., Birren B.W.;
RT   "Contrasting host-pathogen interactions and genome evolution in two
RT   generalist and specialist microsporidian pathogens of mosquitoes.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJW01255.1}.
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DR   EMBL; AFBI03000211; EJW01255.1; -; Genomic_DNA.
DR   AlphaFoldDB; J9DF71; -.
DR   VEuPathDB; MicrosporidiaDB:EDEG_04040; -.
DR   HOGENOM; CLU_410504_0_0_1; -.
DR   InParanoid; J9DF71; -.
DR   OMA; NRNISAW; -.
DR   OrthoDB; 1362946at2759; -.
DR   Proteomes; UP000003163; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 2.30.30.60; -; 1.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   InterPro; IPR016688; MscS-like_plants/fungi.
DR   InterPro; IPR023408; MscS_beta-dom_sf.
DR   InterPro; IPR006685; MscS_channel_2nd.
DR   PANTHER; PTHR31618:SF7; MECHANOSENSITIVE ION CHANNEL PROTEIN; 1.
DR   PANTHER; PTHR31618; MECHANOSENSITIVE ION CHANNEL PROTEIN 5; 1.
DR   Pfam; PF00924; MS_channel_2nd; 1.
DR   SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003163};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        55..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        139..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        221..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        437..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          484..550
FT                   /note="Mechanosensitive ion channel MscS"
FT                   /evidence="ECO:0000259|Pfam:PF00924"
SQ   SEQUENCE   669 AA;  78425 MW;  FAFDE5060F76F215 CRC64;
     MNQRIANTEL FDRDETFISI DLDSKFEENE SKFSRIRSIL FIFLHKLHRF LWLRSFKYIY
     VSIPIAAICL IFHDKKIKFY IAESEVNTTL NTSEKTESIA QNLENDLKTV PNTLLGLITP
     EFNRKIAKRT RKILTISDIA GILYCILFSH ILMSNLVYFL VQLYISRWRS RSYMCLYFLD
     IYEHISIFLA CICALATSYI INKDFGIEYK IYGFFGVRDL IPMIFILNLL TGATHFLISY
     LYMEFSRNIY TERRLRVMRI CFFFRFFNKL YEQKAKDSNI NRDTFYLKAF PPIITKKTIK
     NDMLAKEVHD LYFDPKKTEI SDGAKNMIYR TFKWLKHNAT MHIKSKANIQ KSTNFSENVY
     RLSQLIYNRA VKPRKLGKYF PENINYNNLF ASIGLPPDLT SLKTNTLQPL VNELMQEVFR
     VDKSLSQMTS AIRSLRFATY FVIFIFMATY IVSTFLTTLP ETIGLISAFG GAAVAFKGSV
     NSAVDSIIFV FFIHPYDVGD RIFIQSGGEK LNVVVKELNI FSTVFTKFDG TQTFMPNSLL
     SNTQITNVRR SGWMSDSHQI KIDINTKDKD LVLLKVDIAL YLRRNYDKWD DNFMFNFENI
     EDSRTINCRI FLTSKDNWQN YDKYIKHKGD FLKFLCDTMT HRGIKYTLPV KIVSIKRIPC
     KNKIINNAL
//