ID   J9EWC7_WUCBA            Unreviewed;       607 AA.
AC   J9EWC7;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=Degenerin mec-4 {ECO:0000313|EMBL:EJW79494.1};
DE   Flags: Fragment;
GN   ORFNames=WUBG_09597 {ECO:0000313|EMBL:EJW79494.1};
OS   Wuchereria bancrofti.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX   NCBI_TaxID=6293 {ECO:0000313|EMBL:EJW79494.1, ECO:0000313|Proteomes:UP000004810};
RN   [1] {ECO:0000313|Proteomes:UP000004810}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA {ECO:0000313|Proteomes:UP000004810};
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Hepburn T.,
RA   Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M.,
RA   Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA   Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Wuchereria bancrofti.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC       ECO:0000256|RuleBase:RU000679}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJW79494.1}.
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DR   EMBL; ADBV01005419; EJW79494.1; -; Genomic_DNA.
DR   AlphaFoldDB; J9EWC7; -.
DR   Proteomes; UP000004810; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   InterPro; IPR004726; Deg-1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00867; deg-1; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF275; DEGENERIN MEC-4; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136}; Signal {ECO:0000256|SAM:SignalP};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|RuleBase:RU000679}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..607
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003822742"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EJW79494.1"
SQ   SEQUENCE   607 AA;  69583 MW;  28D4E35102FE783C CRC64;
     TIWVLLFLGC LTMLYHNAES VLDKYHRNEK IVDIQLKFDM APFPAITLCS LNPYKASLAT
     DVDVIRRMLT AFDGALNKAS RIISSNINQR KQRYAGTVEK AQKASMFEPG YSKYICDDSI
     DTKRECEGEK HKYEKPKNNR EKCICAFDRS TKDAWPCYRD FYWSKNICQK CDSGAFCERV
     LTMNMTGQQN SSIPCICAPS GVFCVAYNGD SDIINIWEYL TDGQSAEDST FVEAMGFDGM
     TDEVAIVTKA KENIIFAMAA LPMKDRQRIS TTKRELVHKC SFNGVACDID HDFLTHIDPN
     FGSCFTFNHN RSMNLTTLRA GPMYGLRILV YVNESEYMPT TEATGIRLAI HDKEDYPFPD
     TFGYSAPTGY ISSFGLRLVI YVKNKTDDKA PYGDCIPDGK TSDYIYENYD YSGCYRSCFQ
     QLVLKDCHCG DPRFPVPPGH KHCKATDPAA RLCLYKRTNE LGELNGSFHC RCQQPCKQSI
     YSVTYSPAKW PLRSLNVQLG ICNGTSAECN RHYKENSAMI EVFHKQLNYE MLTESEAYGY
     RIIYLSIRKF IGRFWRTAWP MCGINFLTCC EFIFLLCETA YMSAQYNYIL WKKKEKAREF
     DNHNNLL
//