ID J9EZL0_WUCBA Unreviewed; 768 AA.
AC J9EZL0;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Phosphoinositide phospholipase C {ECO:0000256|RuleBase:RU361133};
DE EC=3.1.4.11 {ECO:0000256|RuleBase:RU361133};
DE Flags: Fragment;
GN ORFNames=WUBG_01061 {ECO:0000313|EMBL:EJW88031.1};
OS Wuchereria bancrofti.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX NCBI_TaxID=6293 {ECO:0000313|EMBL:EJW88031.1, ECO:0000313|Proteomes:UP000004810};
RN [1] {ECO:0000313|Proteomes:UP000004810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA {ECO:0000313|Proteomes:UP000004810};
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Hepburn T.,
RA Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M.,
RA Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "The Genome Sequence of Wuchereria bancrofti.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-
CC diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456,
CC ChEBI:CHEBI:203600; EC=3.1.4.11;
CC Evidence={ECO:0000256|RuleBase:RU361133};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJW88031.1}.
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DR EMBL; ADBV01000223; EJW88031.1; -; Genomic_DNA.
DR AlphaFoldDB; J9EZL0; -.
DR Proteomes; UP000004810; Unassembled WGS sequence.
DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd00275; C2_PLC_like; 1.
DR CDD; cd08591; PI-PLCc_beta; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 2.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR001192; PI-PLC_fam.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR InterPro; IPR001711; PLipase_C_Pinositol-sp_Y.
DR PANTHER; PTHR10336:SF211; 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4; 1.
DR PANTHER; PTHR10336; PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN; 1.
DR Pfam; PF00388; PI-PLC-X; 1.
DR Pfam; PF00387; PI-PLC-Y; 1.
DR PRINTS; PR00390; PHPHLIPASEC.
DR SMART; SM00148; PLCXc; 1.
DR SMART; SM00149; PLCYc; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
DR PROSITE; PS50008; PIPLC_Y_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|RuleBase:RU361133};
KW Lipid degradation {ECO:0000256|RuleBase:RU361133};
KW Lipid metabolism {ECO:0000256|RuleBase:RU361133}.
FT DOMAIN 217..334
FT /note="PI-PLC Y-box"
FT /evidence="ECO:0000259|PROSITE:PS50008"
FT COILED 722..749
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EJW88031.1"
SQ SEQUENCE 768 AA; 89049 MW; DC1C278789150010 CRC64;
FAGKEKVDAE HFAKYLKEEH YDPRLNELLY PSPTSQIAQC LINEMNGSGE QVKQLTKESF
LRFLLSEYNI GMHRDHLMLK EENMHKPLSH YFINSSHNTY LRGYQVNSKS SVEMYRYVLL
SGCRSIELDC WDGSGGEPII THGPSQLTRV TPVLFKDVIM AIAETAFVIS EFPVILSLEN
HCSMKQQKKI ALYCREIFGN FLLTEPLSNY PVVARELSDL VNYMRAMGKF TSFTDCESKQ
MSYGIFSMNE SRAYELVKEN PIEFVNHNKK QITRVYPKGK RVDSSNFWPI KFWNCGCQMT
AINMQTPDIP FQMNVAFFEQ NGHSGYVPKP SLMRKADAKF NPFEMHTMDL VVPAYLSVTV
ISAQMLSFAC ERRPSTYAEV NFYGHFNDLS RFSKRKYRTR IVMDNGINPV YMDFCEESFK
FEKVRSIQPG FRHIPLRNAH SHPLGPVSLF VLFLVHDYID DGSLNLVNTL QNPIEAMKKI
MESEEAASAA LINPIDTMKQ REKMLVALEE SEPKSLSTES TIWDLVEEGK EFSSMDHGQN
LENNAALLLK MRSTSAESEL AKEGSICEDG IKSFNFDKWN VSEKLKERFY LDDMEIRFLR
EGELASSRKV VKLEKSFKKK YEDILNLVDG SSKKKPISSA MRNVHEDAFI IYAKYEKERT
ELIISLAEQN RKKLIKRLNM AYKYESKQLT RLNHQKRYAE QWSATRTEGT EELRGKYVKL
GVEEQRRLNK SKEKRLKEID ENFELLKHEI EVRMEQRLGK AVSVLHDL
//
