ID   J9F0S3_WUCBA            Unreviewed;       894 AA.
AC   J9F0S3;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Importin-beta domain-containing protein {ECO:0000313|EMBL:EJW88491.1};
GN   ORFNames=WUBG_00594 {ECO:0000313|EMBL:EJW88491.1};
OS   Wuchereria bancrofti.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX   NCBI_TaxID=6293 {ECO:0000313|EMBL:EJW88491.1, ECO:0000313|Proteomes:UP000004810};
RN   [1] {ECO:0000313|Proteomes:UP000004810}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA {ECO:0000313|Proteomes:UP000004810};
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Hepburn T.,
RA   Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M.,
RA   Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA   Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Wuchereria bancrofti.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the importin beta family. Importin beta-2
CC       subfamily. {ECO:0000256|ARBA:ARBA00038423}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJW88491.1}.
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DR   EMBL; ADBV01000104; EJW88491.1; -; Genomic_DNA.
DR   AlphaFoldDB; J9F0S3; -.
DR   Proteomes; UP000004810; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   PANTHER; PTHR10527:SF3; FI21453P1-RELATED; 1.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
FT   DOMAIN          36..104
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
FT   REGION          327..375
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        327..343
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   894 AA;  100079 MW;  AE51A91FA2C9BB32 CRC64;
     MTGEAEDWRP IPDELQQVVQ LLQHSQSPDT QTQRNVQERL DQLNLHPEFC CYLVFILSEL
     KDEQVANRSL AGLILKNSIR MLWGRLPEPI RHYVKNKTLL AISDCHPLIR ATVGIIITTI
     VVHEGIAQWP ALLPTLCNML DGSDENLQEG AMGAIQKICE DSADMLAPQE HLSTLIPKLL
     CFFNSSSPKL RALALNSVNC ILLVQTEPLN NIMDVFLQHL FALANDTDTE VQKQLCRSLT
     LLLDSHLDKL ASQLGNIVEF MLLRTQDPNE ATALEACEFW LALAENPQVC KEALLPHLPK
     LIPVLVRCMR YSDMDVAVLK GDIDEEDGAI PDRQQDIKPR FHRAKTQTQT QRKSDTTAEG
     ESMDDDDDGD DDSSTEWNLR KCSAASLDVL SSIFNDDFLP TLLPILKETL FHNNWLIKES
     GILALGAVAE GCMSGITPHL PELVPFLITS LQDRKALVRS ITCWTLSRYC HYVVQQDHNM
     YFKQLLKELL ARILDGSKRV QEAACSAFAT LEEEANLELV PYLPEILATL VEAFSRYQAK
     NLLILYDAVG TLADSVGPNL NEPQYVETIM RPLMSKWAAL GDDDKELFPL LECLSSVATA
     LHEAFLPYCE PVFQRCTALI GRCLQQSQLA MERPAEYDMP DKDFLIVALD LLSGLAEGLA
     EHIDSLVGPS QIIALVYQCS MDSSAEVRQS SFALLGDLSK ACYHYLQPHI NIFLPILAQN
     LDPDSISVCN NSIWAIGEIA MKMGESMRPH VLGLLPALII VMNREKGPKT LLENTAITLG
     RLGISCANEV APFLPQFIRP WCLALRNIRD NEEKESAFRG LCNMINLNPA GVLAEFIFLC
     DAIASWNNPQ PELKMMFSRI LHGFRQQVGD LNWTAFTSQF PAPLKQRLAN QYDV
//