ID   J9F9X6_WUCBA            Unreviewed;       903 AA.
AC   J9F9X6;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 23 {ECO:0000256|ARBA:ARBA00019696};
DE   AltName: Full=Mediator complex subunit 23 {ECO:0000256|ARBA:ARBA00031961};
GN   ORFNames=WUBG_04935 {ECO:0000313|EMBL:EJW84154.1};
OS   Wuchereria bancrofti.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX   NCBI_TaxID=6293 {ECO:0000313|EMBL:EJW84154.1, ECO:0000313|Proteomes:UP000004810};
RN   [1] {ECO:0000313|Proteomes:UP000004810}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA {ECO:0000313|Proteomes:UP000004810};
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Hepburn T.,
RA   Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M.,
RA   Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA   Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Wuchereria bancrofti.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 23 family.
CC       {ECO:0000256|ARBA:ARBA00010222}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJW84154.1}.
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DR   EMBL; ADBV01001780; EJW84154.1; -; Genomic_DNA.
DR   AlphaFoldDB; J9F9X6; -.
DR   Proteomes; UP000004810; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd10388; SH2_SOCS7; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR021629; Mediator_Med23.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR035866; SOCS7_SH2.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR12691; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23; 1.
DR   PANTHER; PTHR12691:SF10; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23; 1.
DR   Pfam; PF11573; Med23; 2.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   3: Inferred from homology;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          743..836
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          846..891
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
SQ   SEQUENCE   903 AA;  103378 MW;  08E6B222DAFA054A CRC64;
     MNIVLCSALE QVMMRYWMWN SPQEMFYLSN AFLGKQGKLA VIFNTANPAF CDPQHGNVST
     EQQYTNSHIS PELLRCLLLS MFRSLKMTGI YNICIVLSVI IKRMEMTSEM MQRCNVNFCW
     PLSINRTYSS QLIGCNVDDG AADTVIYDEL MHRVIQEVHQ IQEIIYAQGL AAEEQLLKFF
     SGERRQTIFC VVYNMLFETK KIHPVIYSVL SSMNNKELTA TINKFTDYFI FIFKKNLPSD
     DQQFTAVGSY PDLHNRITAL VHIIPSNKIG NTGAAFFNKM SEYYSQFPEL SYREMEAKMR
     REMQIELGMR PIEQSTVNPE LHMPIYYGNI MERILPIVDI ILLRAIETVV ADQLFTTLLM
     CFKPCYRYHP QPAAYMYSVL YCLDKTISHT VRARDFVLEI CGQLEDRDGK YALLTPSFIS
     DNHQLSLPSQ FCQALVDRIL QASNYAHQPP AFVYKDWRFA EMPPAGQALT GACIELLASP
     HAPVITAHAL IDLVFIRPLH QPYATINAVA LILTALPVSF QQVFYEHIVS VLDSEVLHGD
     PSVCFGSLES ECFLLTENQL LTNLALGHAY LQHCNTSSLA ALPEFVRDQL APKLVTEAQL
     IFVLRLVVPI LQRFYDAKER SKQIQDLAVD VYKMTVKVNE RVGVLKYEDS ICDFLYHMKY
     MYVGDFVKNE AEQAIQRLSP SMRNKLKYIS HTQINATIDL PHKLAPGPSN SDAVRRDVWM
     EHGAASHTVQ FSQTMKLIRG SSWYWGNMSW KDAEKVLMSQ LPGTYLVRDS ASDRYIFTIS
     YRTKHSVHHT RLAQHGGNFC LGGPNSLVKA NSLVSFIENS LQSCCKRRIC MLMHPKSDST
     GIETLELNHL LRRHELLPSL KYLCRVVIRN CVEKELLASL PLPSNMICYL EDPKYFVPPC
     LYR
//