ID J9FJN6_WUCBA Unreviewed; 782 AA.
AC J9FJN6;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=Ion transport domain-containing protein {ECO:0000259|Pfam:PF00520};
GN ORFNames=WUBG_01559 {ECO:0000313|EMBL:EJW87529.1};
OS Wuchereria bancrofti.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX NCBI_TaxID=6293 {ECO:0000313|EMBL:EJW87529.1, ECO:0000313|Proteomes:UP000004810};
RN [1] {ECO:0000313|Proteomes:UP000004810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA {ECO:0000313|Proteomes:UP000004810};
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Hepburn T.,
RA Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M.,
RA Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "The Genome Sequence of Wuchereria bancrofti.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJW87529.1}.
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DR EMBL; ADBV01000361; EJW87529.1; -; Genomic_DNA.
DR AlphaFoldDB; J9FJN6; -.
DR Proteomes; UP000004810; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR PANTHER; PTHR10582:SF30; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13606; Ank_3; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 583..602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 631..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 667..687
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 195..227
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 296..328
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 583..693
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 743..770
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 782 AA; 90036 MW; C349CC905C2D23DB CRC64;
MGNVESSAAQ GEGTRKQGKP TPKLYRFVDI YGGGELIPWM KYAKDTGDSS IIDEFIETKL
KDFMYNSGKG KMVSVAELVK IRNKERNAML SALKRKKGKG KSGPNILDEF RQEGENQGDL
KKFTLKLLEG DDKRGKSEWK YREVTWKLDE RGLMGENLVG VCLLHGTAIH NQLAIKLIKA
YPKLVNDIFI SEDYYGLSPL HQAIINEDPA MVLFLLRHGA DINQRCYGAF FCPDDQKSSR
TDSLEHEYVE LSLKTTYNGR MYFGEYPLSF AACINQTDCY RILIAKHADP NRKDTNGNTV
LHLAVIHEQP EMLKLCYDTG AKLQIMNSRN LTPLTLAAHL AKKEMFEQIL KLEADVIWLY
GDASSHAYPL AKLDTINQET GELNEDSALS LIVYGETTKH LQLLDGLLGD LLQVKWESFA
RTRLALSFGC YLFFYICTFT AFMCRPFSLT DESIIVNYLD TMVLFNVDNS SLNSTDGDQT
MTSSLVAINL LEDSKTDSQN LERLLQIDYS CGHWWYFGHG WQQNLRLVAE VAVLLMTIFQ
VVDDVMDIRS TGRKRWWRIL SCKIYRTIRF DDIYNLVARF KPIFLIYAIF LIGFSQAFYI
IFMSCNRQKA EYQNATLSKD TDGIMDHPME AIMRIFIMTI GEFMVFYRKM VTSCDRTMMI
YIGKAMFIIY ELFVSVMQLN LLIAMMGRTY DLISGTQTEW KRQWAQVILM LEFSLNPKAR
LNALLKYSRP IGISKQERAF VVVRKTSDSL SEMEKQFRKK QEQCMREKKR ALLKRRLKVL
GD
//
