ID J9FKB2_WUCBA Unreviewed; 1032 AA.
AC J9FKB2;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=RasGEF domain-containing protein {ECO:0000313|EMBL:EJW87799.1};
GN ORFNames=WUBG_01287 {ECO:0000313|EMBL:EJW87799.1};
OS Wuchereria bancrofti.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX NCBI_TaxID=6293 {ECO:0000313|EMBL:EJW87799.1, ECO:0000313|Proteomes:UP000004810};
RN [1] {ECO:0000313|Proteomes:UP000004810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA {ECO:0000313|Proteomes:UP000004810};
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Hepburn T.,
RA Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M.,
RA Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "The Genome Sequence of Wuchereria bancrofti.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJW87799.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADBV01000286; EJW87799.1; -; Genomic_DNA.
DR AlphaFoldDB; J9FKB2; -.
DR Proteomes; UP000004810; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF373; PROTEIN SON OF SEVENLESS; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 235..428
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 479..599
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 649..833
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 881..1032
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 1032 AA; 119872 MW; 0BB135C69A2655EC CRC64;
MLSDTSGGAT RHSMSISVGD ATFNRSLAAN RQSQWKSQKV FIDRIYQISN NCHPGIGLDQ
AAAEHIQEIL ICLFFELLES HPQTIEDMER NMRTTLPASM FHWVMQFQNT PEALHRIPRK
KLHDKRNANS KSLMSLLHML QPKLKELLGY KLDEEVMLYL LSVIEYIAAD ILKWTGNYVK
NIRKCDPTIG LQNLKIALSA DTSLMELTEM LYNEEETSTA GILNDNVEDI VQEMSYDEAS
RDFNREEAQY LRDLNLIIHV FRRRFEIAFE DDTHCLDEMF GNILELHELT VKVQRMLEDA
IEMSDTPCVG AGLWELAEAH EFDVYIAYMD LFKQSLTTVI EKVLNDAKYE QFFLLEDRTH
SITPGGETFR LAVKYVLPSL LEIPVVHFFR YVEFTNILCH LAQPPDEIED LKSTKSYFSG
LAVKVESLCP LFLINHLKTE QSVRALPESN CSRQRRRIQE IQRSIELWEG KEIGYKCAEV
IREGDLLLLR SGPPSSVDTL KKNRGITVRH TFLFDHLLVL CKTLRSSRPE KPLYKFKDKV
LIRKTDIFDL KDTEEFQNAF KIVSRWITHE RGDNTSWILL CRTPEEKTNW MCDLVKIQAK
SSLDRMLDAS LKEEEKRVPL ILPTSDQYRF ADQDCDENIV FEDYTSSSGI PVVKHGTVLK
LVERLTYHLQ LSCVNHPLFR YTDYNYVRTF LTTYHSFCTS SELLQLLIER FQVPTPPQLQ
IAEANNISNL ESRELLNGPC AAAHSQDLGT QFSPTLLNRI ERSYQRFRKE YQQPIQCRVL
SVIRQWVNNH WYDFEHNPVL LQNLCSFLEE TDSHGKVINQ YKKWCKSIKK RADIIPSATH
SALESEPSPV ATTSYGPQKP KILWHIAEKG AIETYDLLSL HPIEIGRQIT LLQFDLYKAI
KPIELVGSAW TKRDKDLRSP QLLKLIDHST MLTYWVARSI VETCSLDERV HMFSRVLEVM
SVFEELNNFT GLVALYSALN SSSVYRLKAC WERIDREKQV WYEKFKKLCN PHWKEMIERL
KSINPPCVPF FG
//
