ID J9HYH0_9SPIT Unreviewed; 2053 AA.
AC J9HYH0;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=HIT domain-containing protein {ECO:0000259|PROSITE:PS51084};
GN ORFNames=OXYTRI_07197 {ECO:0000313|EMBL:EJY71812.1};
OS Oxytricha trifallax.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC Stichotrichia; Sporadotrichida; Oxytrichidae; Oxytrichinae; Oxytricha.
OX NCBI_TaxID=1172189 {ECO:0000313|EMBL:EJY71812.1};
RN [1] {ECO:0000313|EMBL:EJY71812.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JRB310 {ECO:0000313|EMBL:EJY71812.1};
RX PubMed=23382650; DOI=10.1371/journal.pbio.1001473;
RA Swart E.C., Bracht J.R., Magrini V., Minx P., Chen X., Zhou Y.,
RA Khurana J.S., Goldman A.D., Nowacki M., Schotanus K., Jung S., Fulton R.S.,
RA Ly A., McGrath S., Haub K., Wiggins J.L., Storton D., Matese J.C.,
RA Parsons L., Chang W.J., Bowen M.S., Stover N.A., Jones T.A., Eddy S.R.,
RA Herrick G.A., Doak T.G., Wilson R.K., Mardis E.R., Landweber L.F.;
RT "The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome
RT with 16,000 Tiny Chromosomes.";
RL PLoS Biol. 11:E1001473-E1001473(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJY71812.1}.
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DR EMBL; AMCR01015684; EJY71812.1; -; Genomic_DNA.
DR EnsemblProtists; EJY71812; EJY71812; OXYTRI_07197.
DR OrthoDB; 1110761at2759; -.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR019808; Histidine_triad_CS.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF62; SODIUM CHANNEL PROTEIN 60E; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF01230; HIT; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SUPFAM; SSF54197; HIT-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS00892; HIT_1; 1.
DR PROSITE; PS51084; HIT_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU003808};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808}; Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|RuleBase:RU003808};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022568, ECO:0000256|RuleBase:RU003808};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 75..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 701..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 743..764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 845..865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 886..902
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 922..946
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1037..1054
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1074..1096
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1108..1126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1166..1188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1274..1296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1358..1376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1388..1409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1421..1439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1468..1497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1575..1602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1910..1997
FT /note="HIT"
FT /evidence="ECO:0000259|PROSITE:PS51084"
FT REGION 1756..1841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 588..615
FT /evidence="ECO:0000256|SAM:Coils"
FT MOTIF 1982..1986
FT /note="Histidine triad motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00464"
FT COMPBIAS 1756..1777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1778..1801
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1807..1835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2053 AA; 237519 MW; E8CF6602A02E7577 CRC64;
MQANLAAETV HTLIGQEEEY MARLKVKKNL ENNAIFTVHG KIVQYSKKSL FFFEQENTLR
KALVWLTEWR YFDRFIMLII LVNSICLAMF DYSDRDITTY HNQVLYMIGN CITVIFAIEA
AIKIVAQGFV FHKLSYMRDP WNLIDMTIVI TGQILNQIHV LFIFRLADLV ASSVNLKSLR
ILRVLRPLRS INAIPSMRRI VRTLLQSLPE LGNATIFLSF MIVLFGILGL QQFNGILYNK
CRLTEQPVNS TYWPKSKEFT RVCSQAGDGD FVCPNGLYCG NPIDYGISLD DDGVYFDERI
QFGISSFSNF GQAILAVFQI ITKDNWSQLM YNLSDGYTSA FGKIYCIFII VIGSYFMLNL
ILAVIMSNFT KISQLEQKIY IKKMEKELSR QDRRGTAKSV QLEVLTNTNQ RRKSQFQLKN
KGSSKSININ KRDQMGEFQP IKEEKEEELD QQQIFLDSPD RAKLSPFKQL MMIKKQKEAE
KLQQAKAIQD LSEQSNTLHK QHSLNTGKNI ATGFGLALMS KAFSINPQED EQINNIKRQL
TDAESNQDLM IRIKMQQKLY DEQKKTLQRM DLDIRKRYAM SKNNVYGIDN ENQIIQQIQT
RLQEVLIERE KIRQERMIEK GFDPSHLDED IEDELEEKTL VSLKVAQNLK ELTMKQHIKE
LMFNKFKSQL IKKNMIEKLF NKIDEQMISN LLLVRASKNR WYSFSLVIVK SYLFSFIIVL
SIIGNAIVLA MDRYPIDRKQ EDLLEVFNLT FFGLFLGELI LKLSANGIKF YLRDKFNWFD
GGVVVISSID VITSYTVIDN SAGSGAISAL RVFRLIRIFQ LAKVWKDFQD LLTVITNTIK
DISNISILMG LFILIYALLG MELFAYKAQF DKDNRPSNDG EYPQSTFNSF IQALVSVFIV
LANDGWTKIF FNHYRVTDSV TASFYFLSLL IFGQFILLNL FIAILIENFE QVSLHQDTVN
RHKNITWKVT LAKICQKIFY CCKKRRVRIL SEIELEKQKK KQENSDLKEK GESSLYIFTP
NNRFRKFLLE KVSSNKFEYL MIGFIVANSV LLALDNPLND PNSQMSDVLF KIDGVLTAAF
LLEAAIKIIA YGFAFCGSTS YIRNSWNIAD LLIAILSLVS LIVSSQDLSV LKVLRLLKVL
RPIRVISKNE GLKISIRSLG IALPGIFNVI IITLVFHLIF GVIGINYLKG RLFLCDTKHL
PNFDHKSIQD KWECLVVGGE WNRFFLNFDN IGQAMSSLFQ ISTTINWVDL MYQSAATTDI
DLAPQHFYNT GIPIFFIAFI VVGNFFLLNL FVGVVISTYN REKEVLGKNF LLTKKQRKWL
NNKIMLIQSK PMIRMKKPNQ DWRGPFFQLA TNSHFDKFIL ICILINTVIL AVKWYGQHQA
LDNVTETINY VFAFVFIAEV VIKIIAFGVR YFKDDWNNFD VLIAVITIIS MILASKTSVQ
LGPNTTIVRS FRIGRVFKLF RRNKSLKIIF QTFMLALPAL ANIGSLLLLI IFIYSILGMY
LFADVKLGGL INNDANFQNM GNSIQALFRI STGGDWPKLM NDYQQGIQNQ FQCIKNPTYD
DYVNNNYETI GCGDYYFSLI YFFSYVVLVD LLYLKLFIAI ILQGFHDITE KDNKLLNSDH
SDHFREIWSV FDPNATTFIR CTNYGKFLIY LGDPLGWDSS YEFNYLKQEE YLALVDLPKY
NHHKDYQFMD VFENLALLMI VRKEVSDYLG RYNEKLNNLQ QLKHLLSVRQ GLGSIEEERS
YSSVLFSSDK NVLSSDKTIK NSQRHQTNNQ SNLGAESIKS KDQEKEREKR KSRKLDEGDL
KINLEYTFQG RNGNDRRQRN SCYDSLGQNQ GSKDTHYQTQ EREVESYSYF NIPKNLQNYN
FVEIKQHREN TGEVRKHRNK VIQTNYKDSY DIEAQLEEIG FDNGDIRGGV FAMVVHNPIA
KGHVLVCPRN AIARYRDLDT KDLFEISLTV QLLTRFLQDY YQTDSSTVSI QEGQGAGQMI
NHLHVHIIPR FKGDFKNNDD IYPLIEKFDE NFLKTLAEDN STNAQLAEDA AFFKRKLNEL
VPEERFTDPS FNF
//
