ID J9IC66_9SPIT Unreviewed; 4240 AA.
AC J9IC66;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Dynein heavy chain family protein {ECO:0000313|EMBL:EJY78057.1};
GN ORFNames=OXYTRI_24792 {ECO:0000313|EMBL:EJY78057.1};
OS Oxytricha trifallax.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC Stichotrichia; Sporadotrichida; Oxytrichidae; Oxytrichinae; Oxytricha.
OX NCBI_TaxID=1172189 {ECO:0000313|EMBL:EJY78057.1};
RN [1] {ECO:0000313|EMBL:EJY78057.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JRB310 {ECO:0000313|EMBL:EJY78057.1};
RX PubMed=23382650; DOI=10.1371/journal.pbio.1001473;
RA Swart E.C., Bracht J.R., Magrini V., Minx P., Chen X., Zhou Y.,
RA Khurana J.S., Goldman A.D., Nowacki M., Schotanus K., Jung S., Fulton R.S.,
RA Ly A., McGrath S., Haub K., Wiggins J.L., Storton D., Matese J.C.,
RA Parsons L., Chang W.J., Bowen M.S., Stover N.A., Jones T.A., Eddy S.R.,
RA Herrick G.A., Doak T.G., Wilson R.K., Mardis E.R., Landweber L.F.;
RT "The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome
RT with 16,000 Tiny Chromosomes.";
RL PLoS Biol. 11:E1001473-E1001473(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJY78057.1}.
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DR EMBL; AMCR01009945; EJY78057.1; -; Genomic_DNA.
DR EnsemblProtists; EJY78057; EJY78057; OXYTRI_24792.
DR OrthoDB; 275566at2759; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1565..1705
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1847..1974
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2189..2338
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 2823..2850
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3009..3071
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3384..3411
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4240 AA; 490889 MW; 26F8C95026CBC0DE CRC64;
MEQKKKDLHS QSVRDLTQSQ FVMNRDASDL QQKLLAQRLY AKYSDTGHII PNKLVGPPMP
SGSSILGSHR RSLQIDDSVL SLNKKSASLA RFKRPEELMS PDAQEVRKNS QMRAKLPKIQ
SRKHIDISQT PLPTLPFPRV LGKDIISPFP GSQDHLALKR IIAQHQAQAS ILADSQNLTA
STSQQILNSY RNGAQGSGFL AQSQSQLTLK TALQNPTHNQ TLLHNQSTLS LISPNDKTLA
ILESHQRRNN RTSLTHHQSF QQLLPIDNSK ILNSTLEAHG QHHNGTHDQT QTNASALILR
NVPLPNYEQT KQIMTFDPAK IKPKPTSDIK KIMVRQGMKP TPLEFIKLVQ LDPDFQNRFC
YCNKKEDFYE FEIVPFSDKN EAEYMTVSQR GVVHFIKGEA NFMSIPEWER EQRIYKNIQK
IPFFLKYRTW KTFSAWKTLM RRTMIFKTSD FLNRELFILD SELSKPLLDI RMKTFNIQKM
QMVAMNTEKP RNMQEFFEHQ DKQRKTVNES LNKIEKEIKN ILIDSCDSSM RTFREENRIS
LNDNQEDDDN EEAEPFLVGD ETHKQMPYTQ EATTRTHYKK LAKYIRLTDY MIIDSKLRLI
QYSITNVLKI VQLDFKLPRK FLIGDKIQQV PLFEITIDFQ GFDLYFNPNK FDVRDAIKNS
ITEGVNSVCR YELFINQPEF ETYINVQEQE DHLFDEQNDL MSLAIGSDML IRDTELISQA
IDGVFDDMKE EVKEYDQFVQ IYNENITTTA EDFRQRDHDF MNQKIKQLEN QQEEIDRLDV
RKTIKVVRLD GEKMKKRIRE SPKQVWKMLQ DFIPKFQFEK LDALCETLKL EFSKIANKPQ
SIDQFVVIMK DLNDLSGRID NFASMFQEIE EYNILMDEHK IKLPDKNKSK FKETQSLLIK
TRKQMEEGLE AGEVEELKFK KQLIDTEIPK LNKQSKAILD ELTNVMFSDS KTQIMDAVRK
LEEIGESVTQ MKERGKQLNT YQKFLELEDT PFESVNDAFN DWNLKYKLWK GLDEWIYLSR
DWVNTKFTAI DVEDIQKQVD KFFSSASVCY INMKENPVTQ IFKEKVDVLK STMPVVSYLR
SDLQERHWIE IYDILGMTLD LNNDDFTLNS LIELNVKQEK DKIGEIAQKA EKEKELEATY
EKVAAEWRKA IFETKQHKDA YFILGSTEDV NNLLEESMVT LSNVLGARFV DIIRELVEQL
YKKLQYLENL LNEWQTFQRT WMYLENIFNG SDIAQKMGQD AKKFQTVDAQ WKDIMKSTHG
NPGVKRFIDN NYKDGQPYLD LFKNNNKILD DIQKSLEVLL EKKRSEFSRF YFLSNDELLS
ILAEASRDPE CVQAHLRKLF ENINRITFEY DEITKIISAE KEVIKIKKVK TGGNQPVEKW
LLQLQDNMMG AVKKFIKDAH YAYKEDEEFK RHQWVMEDHP AQAVCVVASI NWCGATENLL
KDEDEVSEGL AWWYSENVKQ LEELTKIVSR SDIDSRKRKA VVALITQDVH YRDIVEELIK
EEVENPHDFK WQQQLRYYYS NEEIAIKQVN AQLDYGYEYL GAHTRLVITP LTDRCWMTIT
GSLHIKLGAA PAGPAGTGKT ESTKDLAKGL GKYCVVFNCS DQINYKMMEQ LFSGLASTGS
WACLDEFNRI DIEVLSVIAQ QILTIRNAML QQRTEFQLGD RYIGHFVDTM GIFITMNPGY
KGRTELPDNL KVLFRPVSMM IPDYALIAEI MLFAEGFVQA KPLSRKMTKL YKLASEQLSQ
QAHYDFGMRA VKSVLVMAGQ VKRNNPKMPE DIVLIRAMRD SNIPKFIKED LPLFNAIVKD
LFPGTQLPES QYDMLIQAIN DTQSQSGLTS DPYQIEKIIQ FYETMNVRFG LMIIGQTLTG
KTTIIKSLKQ AMNQMRKNGY TGEDYLAVES ETLNPKSISL DELYGSFSHL TQEWTDGLAS
QLIRGFVEKT HNDMKWVIFD GPVDAIWIEN MNTVLDDNMT LCLSCGERIR LRPEMRMIFE
VDDLSQASPA TVSRCGMVYA SPSTLSWKPL VSSWIQQLPE ELLEKTQKIQ LQWLFDTHID
NTIELVRGKA FKEPIPTVDN NFVISMCRLM QSILEHVIDI KKYVGDRQKK AIIKIFIYCL
AWSFGGSIDS QHYSSFEVYL GTAFNISDLP KTSIFDNKLV QGAEMLEYAT WVQDLPKFEY
SSDKSFFELV VPTKDTVRFS WLLKQNIING NPVFFTGITG VGKSIIANST IAEMKKKMNY
EAIILSFSSQ TSSKETQNQI EDKLEKRRRT LLGGPNGKKV ILFIDDVNMP AYDDYGTQMP
IELLRQFIDF KGLYDREGLY WKNIQDTTLI CSAAPPEGGR KVLSKRFTRH FHMICLPPTQ
EESLQMIFMS IIDGFFTPFK KDVQMLSKPM VDSTLLIFKK ITAQLRPTPA KSHYTFNLRD
ISKIFQGVCM AKTQTLNRND KMIKLWIHEA SRVFHDRLVS SEDKKWFTEL VVDLIKNAFR
VDWTHADLFE SKPLIFGDFM KRSVPYEERQ YDEIRDIASM STCIMDYQEE YNIDHMNKFD
LVLFPECLQH ISRICRILRQ PRGNALLVGV GGSGKQTLTR LSAFIADCAF STLEVKKNFN
QNDFRDNLKK AMLPCGIKGE RTTFLINDNQ ITNESFLEDV NNLLNSGEIP NLWLQEDKDL
INNDLRKTAG ERGIYENIYN FYLQRMRDNL HIVLCLSPVG ESFRSRIRMF PSMVNCCAIN
WINAWPEEAL LSVSSRFISK IDIIKEPALK HKIAQMCVYV HQSVEEESHV FYESLKRKVY
ITPKSYLDLI KSYQLFLAEK NQELSVRRNT LFTGLSKLQE TNKEVSRLSE ELITLQPNLE
VSVLEAEQMS KKLEKDKIEA NKKKMVVEEE KRIVDKKAAE VTAQYDIAMA ELSAVLPILQ
EAESALDTLN PNDITEIKST KSPSKGILNT MIMTYMLIER KHDYKKVEWP LCQKMMSVGF
FEKLKSYKKD DVPERVVKAM DKFVQENPDF TPENVKNSSK ACYSLCKWCL AIGNYAKVAK
EIEPKKKMVE AMDAELKKAQ AELQLKENKL REEMKKVEDL ERAYIEVKEK KERLENEIEL
CRQRLGRAEK LTSGLGSEHE RWQENVQILD SRITQLVGDV FIAAACISYY GPFTGIFREK
LVSKWVEECL SQEIPTSDKF NMPLVMGDPM EIQNWNMNGL PSDSVSISNG IIVKYGTRKP
LMIDPQQQAT KWIRTMYADE NIVNQKDIGQ LKITRMGAKD MIKTMELCIK NGYQLLIEDM
GEYTEPAFEP VLLNQTFKSP HGREQINFGD TIIDYDQRFK LYMTTKMPNP HYLPEMFIRV
TVINFTVTQE GLEQQLLAEI VKLENPAIEI KKLELTRAIV NDQKRMKRIE DEILNQLVNA
SDNILDEEDL INFLEKSKIT SGEIKVAMEE NEVAQIEIEE ARSKYQIVAE RGSILYFVIA
DLAGIDPMYQ YSLLYFLRLH NQIISQSEKS ENQDERIKIL MRELTQIVYN NICRGLFNSH
KLIFSFMIGT RILLQAKKIS MSEWNLFLKG VIMDGDIKNI KNPEPNEITE KTWRFILNLE
CTSQEYEGLS DNIVKEYKVW REWFLSKDPQ NLPLPDKWEE CLTRFQKLLI FKAFREDKLV
FKMREFVEQE LGNQFAYPLP VIMDEVFKDS DNKTPIIYVL SPGAEPTALF LRFANKIRGD
SLDAYQIISL GQGQDKFALE CIEKGTKTGT WVLLQNCHLY KSFMPRLEKE VLDINENAGN
IHPDFRLFLT SMPCDYFPVS VLQNGIKITN EPPKGIKSNI IGSLTQLTEE KISGCKRDIE
YRTLLYSVCF FHAVIQERRK FGPLGWNIRY EFNESDFETA TTVMKGMLNE ESESIVWKAL
QQVTGDIVYG GRVTDDIDRR TLMMILTTFL SEEVLQPDYK YSNSGVYTPV FPDDTLLEGL
MRKAKSLPDV DNPEIFGMND NADIAFQLQE SLSMIEIVLS VQPRTSSAAG GGKSPDQIIE
ELANKIEAEL PDLITREGAH KELFIQNKDG LLPSLTTFLL QEMERFNKLV TVIAKSLDTL
KKALKGEAVM GEDIDRMYKS MLNNKVPEMW AFHAYPSLKP LSSWIENLQQ RIEFLKMWLL
KGKLAAYWLP AFFFPQGFLT ALLQNYARKY SIAIDALNFG FQFQTFYKIE DVDTHPGDGV
FFYGFFMESG EINSSTLLLD DAAAGQKYSV VPMIQFRPEK DHKMNEKDFL CPMFKTTERA
GTLSTTGHST NFVIMVEVPS RKVPKHWILR GTALFCQLDD
//
