ID J9ITG8_9SPIT Unreviewed; 897 AA.
AC J9ITG8;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Inositol 5-phosphatase 4 {ECO:0000313|EMBL:EJY75670.1};
GN ORFNames=OXYTRI_02939 {ECO:0000313|EMBL:EJY75670.1};
OS Oxytricha trifallax.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC Stichotrichia; Sporadotrichida; Oxytrichidae; Oxytrichinae; Oxytricha.
OX NCBI_TaxID=1172189 {ECO:0000313|EMBL:EJY75670.1};
RN [1] {ECO:0000313|EMBL:EJY75670.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JRB310 {ECO:0000313|EMBL:EJY75670.1};
RX PubMed=23382650; DOI=10.1371/journal.pbio.1001473;
RA Swart E.C., Bracht J.R., Magrini V., Minx P., Chen X., Zhou Y.,
RA Khurana J.S., Goldman A.D., Nowacki M., Schotanus K., Jung S., Fulton R.S.,
RA Ly A., McGrath S., Haub K., Wiggins J.L., Storton D., Matese J.C.,
RA Parsons L., Chang W.J., Bowen M.S., Stover N.A., Jones T.A., Eddy S.R.,
RA Herrick G.A., Doak T.G., Wilson R.K., Mardis E.R., Landweber L.F.;
RT "The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome
RT with 16,000 Tiny Chromosomes.";
RL PLoS Biol. 11:E1001473-E1001473(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00004580}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004146}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJY75670.1}.
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DR EMBL; AMCR01012132; EJY75670.1; -; Genomic_DNA.
DR AlphaFoldDB; J9ITG8; -.
DR EnsemblProtists; EJY75670; EJY75670; OXYTRI_02939.
DR OrthoDB; 21647at2759; -.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016791; F:phosphatase activity; IEA:InterPro.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00159; RhoGAP; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR046985; IP5.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR048869; OCRL-1_2_ASH.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR Pfam; PF21310; OCRL-like_ASH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00128; IPPc; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098}.
FT DOMAIN 617..813
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 516..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..533
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 897 AA; 104001 MW; 9BDD2DD198D7B028 CRC64;
MNAPFKVRVL SNHAGEKRNL MERIQSIKQF LPRDPNTFAN QKTHAWLWHY STVIPKVMQT
KTVGYDKEDS KESQNFNHSY YEEKLKETID TIKSSNKQMS QIAMDIFFKQ EFEKRQTQYM
IEHELKIFVV SWNVNGQKPP CDDIEDIFTA RNVYLDQRYL EINEMEDIPD LIVFNFQEIV
PLNAKSMILS GQLSQPQLWE KYLIQEYNEY FRKRLQDKLP IPNIQYVDKL ASHGQVGLYQ
VILFRNDKKQ LISDMQLAQI GTGILGVGGN KGAIGCSIKI CETKICVINA HLAASQSKVS
RRNQNVSQIL RNLQFVNNIS EKQNIFEHDV LLWCGDLNYR INSDNFQEVV DMIQQNKLYE
LRNLDQLKLE KAAGNVFGEF QEGKIKFPPT YKFKVGTHEY DSEKVRIPSW CDRILYRGET
LQQQFYTSVT SPITSDHKPV VSYFKATYKE IDPVQQKIVA STILDYLKNL KDNFIPKMKL
STNQILFENV RYGDTQFLHL EIENEGDGLL EYEITKSQDK DNKSQRGDKP RRSQHSGWLS
ITPLRGVIKA GEKKQITFRV QINQREAQLL FLDKDLEEFI QLKTNEPDNC VGKDNKSVRD
ELSQIKFEDV LLLMDTTKLN DFSLPIPKEL HKMVNYILKE GKLKPNIFLN SGNSQQAKQV
REKIDTNQDL KIEDGDDAYT VASVMIDFLQ TLLSPILPTQ ILDEVVFFYE NNGDTDDMVL
QQLIHKLSKE NSMAFVYIVS FFKEMLNYSD KNKLTPEKIC ELLCDCLIGE DKLIDNQNFR
REKSLVRAAP KKSPTKTQRE LDQFTMQRGN TMSMQGGLSV PLVRSNTNQF SGTFTSVHNK
MASQNHGSLP ELEDDDDIKE FDLELQEAEN IGNTSKQSII DAKSKLRYQG LLLHYFI
//
