ID   J9IYQ8_9SPIT            Unreviewed;       719 AA.
AC   J9IYQ8;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=O-methyltransferase family 2 {ECO:0000313|EMBL:EJY85304.1};
GN   ORFNames=OXYTRI_16835 {ECO:0000313|EMBL:EJY85304.1};
OS   Oxytricha trifallax.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC   Stichotrichia; Sporadotrichida; Oxytrichidae; Oxytrichinae; Oxytricha.
OX   NCBI_TaxID=1172189 {ECO:0000313|EMBL:EJY85304.1};
RN   [1] {ECO:0000313|EMBL:EJY85304.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JRB310 {ECO:0000313|EMBL:EJY85304.1};
RX   PubMed=23382650; DOI=10.1371/journal.pbio.1001473;
RA   Swart E.C., Bracht J.R., Magrini V., Minx P., Chen X., Zhou Y.,
RA   Khurana J.S., Goldman A.D., Nowacki M., Schotanus K., Jung S., Fulton R.S.,
RA   Ly A., McGrath S., Haub K., Wiggins J.L., Storton D., Matese J.C.,
RA   Parsons L., Chang W.J., Bowen M.S., Stover N.A., Jones T.A., Eddy S.R.,
RA   Herrick G.A., Doak T.G., Wilson R.K., Mardis E.R., Landweber L.F.;
RT   "The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome
RT   with 16,000 Tiny Chromosomes.";
RL   PLoS Biol. 11:E1001473-E1001473(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJY85304.1}.
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DR   EMBL; AMCR01003217; EJY85304.1; -; Genomic_DNA.
DR   AlphaFoldDB; J9IYQ8; -.
DR   EnsemblProtists; EJY85304; EJY85304; OXYTRI_16835.
DR   GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR031725; ASMT_dimerisation.
DR   InterPro; IPR016461; COMT-like.
DR   InterPro; IPR001077; O_MeTrfase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43712:SF2; O-METHYLTRANSFERASE CICE; 1.
DR   PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR   Pfam; PF13535; ATP-grasp_4; 1.
DR   Pfam; PF16864; Dimerisation2; 1.
DR   Pfam; PF00891; Methyltransf_2; 1.
DR   SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51683; SAM_OMT_II; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:EJY85304.1};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000313|EMBL:EJY85304.1}.
FT   DOMAIN          391..472
FT                   /note="Acetylserotonin O-methyltransferase dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16864"
FT   DOMAIN          536..696
FT                   /note="O-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00891"
SQ   SEQUENCE   719 AA;  81920 MW;  1E1C87D891781803 CRC64;
     MNTRQSTNLF INDDRIYNSS LIEQAVAYAH IVKSHNVGPI QSGTKILCTS IFELSNIKDK
     LPQSLQIAVD TLSNKHLFRE HLASVYPDFY FTKVRLCELT SLQLDFSEDK TYVIKPIYGA
     ASVGVGFIQK DTDLHKLKLS IAQQLQDANQ RLNGVYSLEE FIIEECIGTE FNSLDLDNDY
     TDIELVIDMF YNEQGQPVIT SIIHHPFATD GITKYAFHYT DAHLIKRFIT EATFFFEKFN
     EGMQLVGFPI HGEFKIRQGK LFPLELNPLR FAGTGVSELF YHAYNINVYE IFFKNEEIDW
     QSILNDCSNS YYGVVIGFTP SNCDDESIEH EKFKTFCGQV IEYNQKRSYH KLIFSHAFIK
     AQEKKSFIKF LDINFSHYVQ TNATHINVGS IFKVCMGAWS SQCLLSAIEL GVFQYLHTNG
     MASSHDIAIA TQITLLTPSY FFDVLVLLGL LIKNDLNMYE NSPIASKFCI KGTDQFCGEI
     VKAISSQESN VNWFDLSKKL QVSSDQKFTS NYNIFYEILD QSDAIAGFIA EQSGLTAPIT
     QFVARQQLWT QISSFVDVGG SNGFFAKQIC NYNPNLSGIV CDLPPVQPHF NLYINQYNMQ
     DRITFKCLDY MKDDFPSTDC VVMSHVMMDH TNENQKFLLA KAFKSLKQDG YLILCDTFVD
     TDNLQALLTG IHMQLCVKAV CLTRKEWTIM LQDIGFKVGK IENFDGLHTG VIIAQKNKQ
//