ID   J9JCQ2_9SPIT            Unreviewed;      1041 AA.
AC   J9JCQ2;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=RNB-like protein {ECO:0000313|EMBL:EJY88725.1};
GN   ORFNames=OXYTRI_00057 {ECO:0000313|EMBL:EJY88725.1};
OS   Oxytricha trifallax.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC   Stichotrichia; Sporadotrichida; Oxytrichidae; Oxytrichinae; Oxytricha.
OX   NCBI_TaxID=1172189 {ECO:0000313|EMBL:EJY88725.1};
RN   [1] {ECO:0000313|EMBL:EJY88725.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JRB310 {ECO:0000313|EMBL:EJY88725.1};
RX   PubMed=23382650; DOI=10.1371/journal.pbio.1001473;
RA   Swart E.C., Bracht J.R., Magrini V., Minx P., Chen X., Zhou Y.,
RA   Khurana J.S., Goldman A.D., Nowacki M., Schotanus K., Jung S., Fulton R.S.,
RA   Ly A., McGrath S., Haub K., Wiggins J.L., Storton D., Matese J.C.,
RA   Parsons L., Chang W.J., Bowen M.S., Stover N.A., Jones T.A., Eddy S.R.,
RA   Herrick G.A., Doak T.G., Wilson R.K., Mardis E.R., Landweber L.F.;
RT   "The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome
RT   with 16,000 Tiny Chromosomes.";
RL   PLoS Biol. 11:E1001473-E1001473(2013).
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC       {ECO:0000256|ARBA:ARBA00005785, ECO:0000256|RuleBase:RU003901}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJY88725.1}.
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DR   EMBL; AMCR01000056; EJY88725.1; -; Genomic_DNA.
DR   AlphaFoldDB; J9JCQ2; -.
DR   EnsemblProtists; EJY88725; EJY88725; OXYTRI_00057.
DR   OrthoDB; 945235at2759; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR   Gene3D; 2.40.50.690; -; 1.
DR   Gene3D; 2.40.50.700; -; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR041505; Dis3_CSD2.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR033771; Rrp44_CSD1.
DR   InterPro; IPR003029; S1_domain.
DR   PANTHER; PTHR23355:SF35; EXOSOME COMPLEX EXONUCLEASE RRP44; 1.
DR   PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR   Pfam; PF17849; OB_Dis3; 1.
DR   Pfam; PF00773; RNB; 1.
DR   Pfam; PF17216; Rrp44_CSD1; 1.
DR   SMART; SM00955; RNB; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR   PROSITE; PS50126; S1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          918..998
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000259|PROSITE:PS50126"
FT   REGION          1005..1041
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          355..382
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1012..1032
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1041 AA;  120363 MW;  8ED2D8C615E3EF24 CRC64;
     MLLTTKRVNT VKFRKLQNGK IVRQIEEQYL RQDIPCGLKN CPFCDTNDNC NLLLQLKEVA
     GVKSSIALSQ EDQKFSQRIY IIDHSFALNQ FDFIENCNAL SNIILTDSVL KYINRKNIQA
     FHGLKNLTEQ ESRQIYYLYN ENFTETYVQE SLLKGKGLDL KMKTKLAAVF QWYSDHLQGV
     AQNNQIFLLT DSYKSKQEYL KMIKGPQQEG IITMEDFIIM NQESNPELLN FMGFADEKDM
     QDVDMEEADG VRDLYEDHLS FEEMILGIKE GRYFQGRLNV SRTTLEEATI AIEYLNQDLL
     VVGLQDQNRA FNGDIVCLEV LPESQWISNY KSSQPVNVLE QSAVQYMDKA DEVHVEEDLQ
     NLEESNRQRL NLIEKINNEK QKRVTARVRG VLKKMNKTYG GSIIKSSDQT EETRRKFELF
     LKNLRVEQKD YFKYRVFVPF NLQMPQAIVK SARPEALENK RFILRFSTWT KYSPFPQGQF
     VKIIGEEGSI KTEGEMILHE FNVDTRPFSN KVLQCLPTDG ANWKIPQEEI DKRLDIRHLI
     VASVDPIGCK DIDDALHCRI LPNGNYEVGV HIADVTHFVK AGSEIDKEAA RRCTTVYMVD
     RRTDMLPGLL TENLCSIRGG TERLVFSVIW EIDSKKFTPV KSSFHKSVIK SAAALDYYTA
     QDMINDPNNK TELTESLRRL LTIARILRDR RTAKGALTLA SPELKFKLDD NRETPTDVTE
     YRHVDTHFMI EEFMLLANIA VAEKIVQHYP SFAILRRHPQ PKQKEVAEFV DQLAKYGFEM
     ALDSSKSFAD SLDRAERPND PYFNKIVRIM ATRCMHQAVY FCLADFDISE VFHYGLAVPV
     YTHFTSPIRR YADVLVHRLL AAAIDIQSLT NEMTDKFKMA RQCDQMNRKN RMAALASQAS
     VQFNTYLFFK GLRERNQKDV IEDAIIMKIT KAGAYVMVMK YGIEGLIQEE EEVKIVVDGD
     KEEAIINNGV VLKAFDNVKI EILAVSIEFR RQIKILFRGK SDNQQFDQLP KKRNNQQKEE
     SKDEQNLSEA LSKKSKKKKR V
//