GenomeNet

Database: UniProt
Entry: J9JUC9_ACYPI
LinkDB: J9JUC9_ACYPI
Original site: J9JUC9_ACYPI 
ID   J9JUC9_ACYPI            Unreviewed;       929 AA.
AC   J9JUC9;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   23-MAY-2018, entry version 38.
DE   RecName: Full=Phosphodiesterase {ECO:0000256|RuleBase:RU363067};
DE            EC=3.1.4.- {ECO:0000256|RuleBase:RU363067};
GN   Name=PDE11A {ECO:0000313|EnsemblMetazoa:ACYPI003950-PA};
OS   Acyrthosiphon pisum (Pea aphid).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha;
OC   Aphidomorpha; Aphidoidea; Aphididae; Macrosiphini; Acyrthosiphon.
OX   NCBI_TaxID=7029 {ECO:0000313|EnsemblMetazoa:ACYPI003950-PA, ECO:0000313|Proteomes:UP000007819};
RN   [1] {ECO:0000313|EnsemblMetazoa:ACYPI003950-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LSR1 {ECO:0000313|EnsemblMetazoa:ACYPI003950-PA};
RA   Jiang H., Abraham K., Ali S., Alsbrooks S.L., Anim B.N., Anosike U.S.,
RA   Attaway T., Bandaranaike D.P., Battles P.K., Bell S.N., Bell A.V.,
RA   Beltran B., Bickham C., Bustamante Y., Caleb T., Canada A.,
RA   Cardenas V., Carter K., Chacko J., Chandrabose M.N., Chavez D.,
RA   Chavez A., Chen L., Chu H.-S., Claassen K.J., Cockrell R., Collins M.,
RA   Cooper J.A., Cree A., Curry S.M., Da Y., Dao M.D., Das B.,
RA   Davila M.-L., Davy-Carroll L., Denson S., Dinh H., Ebong V.E.,
RA   Edwards J.R., Egan A., El-Daye J., Escobedo L., Fernandez S.,
RA   Fernando P.R., Flagg N., Forbes L.D., Fowler R.G., Fu Q., Gabisi R.A.,
RA   Ganer J., Garbino Pronczuk A., Garcia R.M., Garner T., Garrett T.E.,
RA   Gonzalez D.A., Hamid H., Hawkins E.S., Hirani K., Hogues M.E.,
RA   Hollins B., Hsiao C.-H., Jabil R., James M.L., Jhangiani S.N.,
RA   Johnson B., Johnson Q., Joshi V., Kalu J.B., Kam C., Kashfia A.,
RA   Keebler J., Kisamo H., Kovar C.L., Lago L.A., Lai C.-Y., Laidlaw J.,
RA   Lara F., Le T.-K., Lee S.L., Legall F.H., Lemon S.J., Lewis L.R.,
RA   Li B., Liu Y., Liu Y.-S., Lopez J., Lozado R.J., Lu J., Madu R.C.,
RA   Maheshwari M., Maheshwari R., Malloy K., Martinez E., Mathew T.,
RA   Mercado I.C., Mercado C., Meyer B., Montgomery K., Morgan M.B.,
RA   Munidasa M., Nazareth L.V., Nelson J., Ng B.M., Nguyen N.B.,
RA   Nguyen P.Q., Nguyen T., Obregon M., Okwuonu G.O., Onwere C.G.,
RA   Orozco G., Parra A., Patel S., Patil S., Perez A., Perez Y., Pham C.,
RA   Primus E.L., Pu L.-L., Puazo M., Qin X., Quiroz J.B., Reese J.,
RA   Richards S., Rives C.M., Robberts R., Ruiz S.J., Ruiz M.J.,
RA   Santibanez J., Schneider B.W., Sisson I., Smith M., Sodergren E.,
RA   Song X.-Z., Song B.B., Summersgill H., Thelus R., Thornton R.D.,
RA   Trejos Z.Y., Usmani K., Vattathil S., Villasana D., Walker D.L.,
RA   Wang S., Wang K., White C.S., Williams A.C., Williamson J., Wilson K.,
RA   Woghiren I.O., Woodworth J.R., Worley K.C., Wright R.A., Wu W.,
RA   Young L., Zhang L., Zhang J., Zhu Y., Muzny D.M., Weinstock G.,
RA   Gibbs R.A.;
RL   Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ACYPI003950-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000256|RuleBase:RU363067};
CC       Note=Binds 2 divalent metal cations per subunit. Site 1 may
CC       preferentially bind zinc ions, while site 2 has a preference for
CC       magnesium and/or manganese ions. {ECO:0000256|RuleBase:RU363067};
CC   -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase
CC       family. {ECO:0000256|RuleBase:RU363067,
CC       ECO:0000256|SAAS:SAAS01040771}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ABLF02031264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_001952168.1; XM_001952133.4.
DR   RefSeq; XP_016661829.1; XM_016806340.1.
DR   UniGene; Aps.101230; -.
DR   UniGene; Aps.30534; -.
DR   ProteinModelPortal; J9JUC9; -.
DR   STRING; 7029.ACYPI003950-PA; -.
DR   EnsemblMetazoa; ACYPI003950-RA; ACYPI003950-PA; ACYPI003950.
DR   GeneID; 100162827; -.
DR   KEGG; api:100162827; -.
DR   eggNOG; KOG3689; Eukaryota.
DR   eggNOG; ENOG410XRI7; LUCA.
DR   InParanoid; J9JUC9; -.
DR   KO; K13298; -.
DR   OMA; ATNRSKW; -.
DR   PhylomeDB; J9JUC9; -.
DR   Proteomes; UP000007819; Unassembled WGS sequence.
DR   GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.1300.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 2.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR023088; PDEase.
DR   InterPro; IPR002073; PDEase_catalytic_dom.
DR   InterPro; IPR036971; PDEase_catalytic_dom_sf.
DR   InterPro; IPR023174; PDEase_CS.
DR   Pfam; PF01590; GAF; 2.
DR   Pfam; PF00233; PDEase_I; 1.
DR   PRINTS; PR00387; PDIESTERASE1.
DR   SMART; SM00065; GAF; 2.
DR   SMART; SM00471; HDc; 1.
DR   PROSITE; PS00126; PDEASE_I_1; 1.
DR   PROSITE; PS51845; PDEASE_I_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007819};
KW   Hydrolase {ECO:0000256|RuleBase:RU363067,
KW   ECO:0000256|SAAS:SAAS01040760};
KW   Metal-binding {ECO:0000256|RuleBase:RU363067,
KW   ECO:0000256|SAAS:SAAS01040765};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007819}.
FT   DOMAIN      596    920       PDEase. {ECO:0000259|PROSITE:PS51845}.
SQ   SEQUENCE   929 AA;  105078 MW;  D8FE3BD014A2A539 CRC64;
     MRENEGADVA ALNDDNMTQI TLSVVEEWLD SHPDHCQDYF LRKIELDLIN KWLVSHGFLN
     INDYISSATS TSSSGNVSPA NGLAVQQVSP AASPNAPSIL VNGTNSLSVS QIYRSNSKRC
     RRHDFARAKT RSVLRTQEIG KDVPICSSRR SSLKDMRKFT SLPPSPISML SLLIDSKVRL
     PRWPVSAHNV DTKRDLRHAQ GERDFFLTVV RDIATDLDLK SLSQKIVDDL AVLLDCDAGS
     LFLVDGPPRG SRRRCLVSKV FDVHSGARGQ FLLPDGVQCE VAGGPPTTTD NEVRIPWGVG
     ILGHVASTGE TVNLDVACED PRFDDEVDRI MGYYTSSLLC MPVKNSYEEI IAVAQVNNKN
     PDKDGGHFTS MDEKLFETYL QFVGIAITNA QIVEDSRAEY DRNRNLLEVV HDLFEEQTSI
     DKVIMKIMQR AQRLLKCERA AVLLVDESCD STRFSKLFDL NSPKHNIKNN VKNSRQKVEG
     ENVSRYLESL AERVACSGEV LNINEHECNE GIVDSGINSL LAMPIRNKND QIIGVASIIN
     KLNSSPFDDY DEQLFEAFTI FCGLGIHNTL MYSEVEKAMA RQKVSIEVLS YHATASNKDV
     ERILGMPVPA ADSLNLYSLA FDDFSLNDDE MLMAAVSMFL ELGLVKTFNI EKETLYRFLI
     TVKRNYRDVP YHNWRHAFNV AQVMFAIMMG CDMKNTFSDL EVLGMFVGCL CHDLDHRGTN
     NSFQEKARSA LVLLYGTTNT MEHHHFNHAV MILSSENLNI FSSLSAESFS TVMKVLKHSI
     LATDLCMYFQ LRNKFFRLIE SKEYSWDEDS QRYLLMAMLM TSSDLAASTK QWHVQKRAAR
     LVTDEFIEQG DKERFELKIQ PQALMDRERQ HELPQLQIRW IADICLPLYQ ALGQMNPKLN
     VMKEGAMNNM HQWSKLVDEN YKNANGEQK
//
DBGET integrated database retrieval system