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Database: UniProt
Entry: J9NZY1_CANLF
LinkDB: J9NZY1_CANLF
Original site: J9NZY1_CANLF 
ID   J9NZY1_CANLF            Unreviewed;      3690 AA.
AC   J9NZY1;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   20-JUN-2018, entry version 31.
DE   SubName: Full=Fraser extracellular matrix complex subunit 1 {ECO:0000313|Ensembl:ENSCAFP00000038852};
GN   Name=FRAS1 {ECO:0000313|Ensembl:ENSCAFP00000038852,
GN   ECO:0000313|VGNC:VGNC:40975};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000038852, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000038852, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000038852,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000038852}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000038852};
RG   Ensembl;
RL   Submitted (SEP-2012) to UniProtKB.
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DR   EMBL; AAEX03016693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03016694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03016695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCAFT00000049130; ENSCAFP00000038852; ENSCAFG00000008752.
DR   VGNC; VGNC:40975; FRAS1.
DR   eggNOG; KOG1216; Eukaryota.
DR   eggNOG; KOG1306; Eukaryota.
DR   eggNOG; KOG3525; Eukaryota.
DR   eggNOG; KOG3597; Eukaryota.
DR   eggNOG; ENOG410XQ7P; LUCA.
DR   GeneTree; ENSGT00550000074429; -.
DR   TreeFam; TF316876; -.
DR   Proteomes; UP000002254; Chromosome 32.
DR   Bgee; ENSCAFG00000008752; -.
DR   GO; GO:0005604; C:basement membrane; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0007154; P:cell communication; IEA:InterPro.
DR   Gene3D; 2.60.40.2030; -; 5.
DR   InterPro; IPR038081; CalX-like_sf.
DR   InterPro; IPR003644; Calx_beta.
DR   InterPro; IPR039005; CSPG_rpt.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR001007; VWF_dom.
DR   Pfam; PF03160; Calx-beta; 5.
DR   Pfam; PF00093; VWC; 4.
DR   SMART; SM00237; Calx_beta; 5.
DR   SMART; SM00181; EGF; 11.
DR   SMART; SM00261; FU; 14.
DR   SMART; SM00214; VWC; 6.
DR   SMART; SM00215; VWC_out; 4.
DR   SUPFAM; SSF141072; SSF141072; 5.
DR   SUPFAM; SSF57184; SSF57184; 5.
DR   PROSITE; PS51854; CSPG; 12.
DR   PROSITE; PS01208; VWFC_1; 6.
DR   PROSITE; PS50184; VWFC_2; 6.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254}.
FT   DOMAIN       17     69       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN       74    134       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      138    198       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      200    260       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      264    324       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      328    398       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   REPEAT     1083   1178       CSPG. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01201}.
FT   REPEAT     1198   1289       CSPG. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01201}.
FT   REPEAT     1309   1418       CSPG. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01201}.
FT   REPEAT     1443   1539       CSPG. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01201}.
FT   REPEAT     1575   1670       CSPG. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01201}.
FT   REPEAT     1691   1791       CSPG. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01201}.
FT   REPEAT     1814   1917       CSPG. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01201}.
FT   REPEAT     1938   2038       CSPG. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01201}.
FT   REPEAT     2059   2158       CSPG. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01201}.
FT   REPEAT     2180   2272       CSPG. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01201}.
FT   REPEAT     2299   2392       CSPG. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01201}.
FT   REPEAT     2427   2524       CSPG. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01201}.
SQ   SEQUENCE   3690 AA;  408004 MW;  282806B1810B5CEA CRC64;
     MFLKSVGNIY YLLVENEDAT TWKPDSCQNC HCHGNIVICK PAVCRNPQCV FEKGEVLQIA
     ANQCCPECVL QTPGSCHHEK KIYAHGTEWA YPPCSVCSCT HGEVRCTPQP CPPLSCGPQE
     LESIPEGSCC PVCVGPGKSC SYEGRVFQDG EDWPLSRCAK CVCRNGVTQC FIAHCQPLFC
     NEDEAIVRVP GKCCPQCSSQ SCSASGQVYE HGEQWTENAC TTCICDQGEV RCHRQACPPL
     RCEKGQRRAH RHGECCEECV SPAGSCSHNG IVRYQDEMWK GSACEFCMCD RGQVTCQTGE
     CAKVECAQGE ELIHLDGKCC PECISKNGYC VYEENTEFMS SNASEVKRIP EGEKWEDGPC
     KVCECRGSQV TCYEPSCPPC PVATLAQVVK GQCCPDCTSV VHCHPDCLTC SQSPEHCDLC
     QDPTKLLQNG QCVHSCGLGF YQAGALCLAC QPQCFTCTSG LECSSCQPPL LMRHGQCVST
     CGDGFYQDRY SCAVCHESCT ACWGPTAKHC MGCRDPLQVL REGSCESSCG VGFYNKQGIC
     SACDQSCKSC GPNSPRCLTC AEKTVLHDGK CIAECPGGYY AEATGRCKVC HNSCASCSGP
     TGSHCTACIQ PQALRQGHCL SSCGEGFYPD HGVCKACHSS CLTCVGPEPS HCAQCRKPDE
     GLQVEHLSGA NITSGECLPQ CRAQFYLENT GLCEACHQSC FRCAGKSPHN CTACWPSQVL
     LDGQCLSQCP DRYFNQEGSC TECHPTCRQC HGPSESDCIS CHPHVTLAGG SCRSSCKEEQ
     FLNLVGYCAD CHRLCRRCTA HLHDPGSTCL RCQNARYLLL GDHCVPDCPS GYYAERGACQ
     KCHPSCRTCQ STGPFSCTSC DANFVLSHLG TCTTACFPGH YLDDSHTCQP CDADCRSCDS
     QASCTSCRDP NKVLLFGECQ YESCAPQYFL DFSTKICKEC DWSCNACSGP LRTDCLQCMD
     GYVLQDGACV EQCSPSFYRD LGLCKSCGNH CLRCQGPHEC ARCEGPFLLL EGQCVQECGK
     GYFADHVNRQ CTACPRACLQ CSRQDQCHLC DHGFFLKSGL CISNCIPGFS AHSNETCTGK
     IYTPSLHVNG SLTLAIGSMK PLDFPLLNVQ DQDGRMEDLQ FHVVSTPTNG QLVLSRNGRE
     VQLDKAGHFS WKDVNEKKVR FVHSKEKPRK GYFSLKISDQ QFYSKPQLIN VEAFSTQAPY
     VLRNEALHIS RGERGTITTQ LLDIRDDDNP QDVVVEVLDP PLHGQLLQIL QSPATPIYQF
     RLDELSRGLL HYAHDGSDSI SDVAVLQAND GHSFQNILFH VKKEKKLQGD KKIEKAMVWV
     PEGGMLQITN RILQAEAPGV SASEIIYKIT QDHPQFGEVV LLVEMPADSP AGEGQHLPDG
     RTATPTSTFT QQDINEGIVW YRHSGVPAQS DSFSFQVSSA SDAHTHLENH MFNIAILPQT
     PEAPKLSLGA SLHMTAREDG LTVIQPHSLS FVNSERPSRK LIYNITLPLH PNQGIIEHRD
     QPHSPIRYFT QEDINQGKIM YRPPPAAPHL QEIMAFSFAG LPELVKFHFT VSDGAHTSPE
     MVLTIHLLPT DRHLPAFRVT APRLEVSPGG SASLEGLQLV VRDPEIAPEE LFFELRKPPK
     HGVLLKYTTE FQVPMATGDT FTYEDIEKNV LQYLHDGSSA QEDSMEITVT DGLAATTVEV
     KVEVSLSEDQ GPQLAAGASL SITVASKSTA VITRSHLAYV DDSSPDPEIW IQLSSLPMYG
     ALLRMSGPEV EELSEVSNFT MEDINNQKIR YSAVYETDGN LVTDGFHFSV SDTDHNHLDN
     QTFTIMITPV ENPPPVIAFA DLITVDEGGR APLSFHHFFA ADDQDNLQGD AIIKLSALPK
     YGCIENMGTG TSSRIRFIST NVASFSIQDV LENYIYYFQS VHESIEPTHD IFSFYVSDGN
     SRSEIHSINI TIERKNDEPP RMTLQPLGVQ LSSGVVISNS SLSLQDLDTP DNELVFVLTK
     KPDHGHLLWR QTASEPLENG RVLTQGSSFT YQDILAGLVG YMPGGPGVAV DEFRFSLTDG
     LHMDTGRMEI YIELPTSGTP HLAINQGLWL SAGSVARITE QHLRVTDTDS DDHQVMYIMR
     EDPGAGRLQM VKRDNLEQIS VKGPVRSFTQ ADVSQGQVEY SHRKGESGGS FAFKFDVVER
     VAERILFQIT FLIFSEDTSP PIITTNKGLI LDENSVEKIT TLELSATDQE SKPTELIYRI
     TRQPELGHLE HAASPGIQIR SFTQADLISQ NIQYIHSSET EKHSDAFSFT LSDGSSESCQ
     EWVKVTQTFH ITIRPVDDSL PVVQSLGMRV QEGVRKTITE FELKAVDADT EAESVTFTIV
     QPPRHGTIER TSSGGHSRHI STFTMEDIYQ NRVSYSHDGS NSLRDRFTFT VADRTNPFFI
     IEEGGKEVMT AAPQHFQIDI LPVDDGTPRI VTNLGLQWLE YMDGKTTNLI TKKELLTMDP
     DTDDQHLVYE ITEGPKHGYV ESKLQPGKAA ATFTQEDVNL GLIRYVLHEE KIHEIMDSFQ
     FLVKDSKPNV VNDNVFHVQW SLISFKYTSY NVSEKAGSVS VTVQRSGNLN QYAIVLCRTE
     EGTASSSSRV SSQPGQQDYV EYAGQVQFDE REDTKSCTIV INDDDVFENV ESFTVELSMP
     AYALLGEFTQ AKVIINDSED EPTLEFDKKT YRVNESAGFL FAPIERKGDS SSIVSAICYT
     VPKSAMGSSL YALESGSDFK SRGMSADSRV IFGPGVTMST CDVMLIDDSE YEEEEEFEIA
     LADASDNARI GRVASAKVLI SGPNDASTVS LGNTAFTVSE DAGSTVRIPV IRHGTDLSTF
     TSVWCATRPS DPASATPGVD YVPSSRKVEF GPGVTEQYCT LTILDDTQYP VIEGLETFVV
     FLSSAQGAEL TKPFQAVIAI NDTFQDVPSM QFAKDLLLVK EKEGVLQVPI IRSGDLSYES
     SVRCYTQGHS AHVMEDFEER RNEDFSRITF LKGEKMKNCT VSIHDDSMFE PEEQFRVYLG
     HPLGNHWSGA RIGKNNMATI TISNDEDAPT IEFEEAAYQV REPSGPDAVA LLNIKVIRRG
     DQNRTSKIRC STRDGSAQSG VDYYPKSRVL KFSPGVDHIF FKVEILSNED REWHESFSLV
     LGPDDPVEAV LGDVTTATVT ILDQEAAGSL ILPAPPIVVT LADYDHVEEV TKEGVKKSPS
     PGYPLVCVTP CDSHFPKYAI MKERCSEAGI NQTSVQFSWE VATPTDGSGA RSPFETITDN
     TPFTSVNHMV LDSIYFSRRF HVRCVAKAVD KVGHVGTPLR SNIVTIGTDS AICHTPVVAG
     TARGFQAQSF IATLKYLDVK HKEHPNRIHI SVQIPHQDGM LPLISTMPLH NLHFLLSESI
     YRHQHVCSNL VTTRDLRGIS EAGFLNNKVY DSTALGPGYD RPFQFDPSVR EPKTIQLYKH
     LNLKSCVWTF DAYYDMTELI DVCGGSVTAD FQVRDSAQSF LTIHVPLYVS YIYVTAPRGW
     ASLEHHTEME FSFFYDTVLW RTGIQTDSVL SARLQIIRIY IREDGRLVIE FKTHAKFREI
     GQFVMEHHTL PDVKSFILTP DHLGGIEFDL QLLWSAQTFD SPYQLWRATS SYNRKDYSGE
     YTIYLIPCTV QPTQPWADPG EKPLACTAHA PERFLIPIAF QQTNRPVPVV YSLNTEFQLC
     NNEKVFLMDP NTSDMSLAEM DYKGAFSKGK
//
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