ID J9PKL8_9CAUD Unreviewed; 241 AA.
AC J9PKL8;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 08-NOV-2023, entry version 29.
DE SubName: Full=Metal-dependent hydrolase {ECO:0000313|EMBL:AEQ34349.1};
OS Bacillus phage Bastille.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Herelleviridae; Bastillevirinae; Bastillevirus; Bastillevirus bastille.
OX NCBI_TaxID=57477 {ECO:0000313|EMBL:AEQ34349.1, ECO:0000313|Proteomes:UP000006285};
RN [1] {ECO:0000313|EMBL:AEQ34349.1, ECO:0000313|Proteomes:UP000006285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Klumpp J., Loessner M.J.;
RT "Large virulent SPO1-related Bacillus Phage Bastille.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Counteracts the host Pycsar antiviral defense system.
CC Phosphodiesterase that enables metal-dependent hydrolysis of host
CC cyclic nucleotide Pycsar defense signals such as cCMP and cUMP.
CC {ECO:0000256|ARBA:ARBA00034293}.
CC -!- SIMILARITY: Belongs to the anti-Pycsar protein Apyc1 family.
CC {ECO:0000256|ARBA:ARBA00034308}.
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DR EMBL; JF966203; AEQ34349.1; -; Genomic_DNA.
DR RefSeq; YP_006907445.1; NC_018856.1.
DR GeneID; 13829082; -.
DR KEGG; vg:13829082; -.
DR Proteomes; UP000006285; Genome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR42663:SF6; HYDROLASE C777.06C-RELATED; 1.
DR PANTHER; PTHR42663; HYDROLASE C777.06C-RELATED-RELATED; 1.
DR Pfam; PF12706; Lactamase_B_2; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:AEQ34349.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006285}.
FT DOMAIN 18..220
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 241 AA; 27660 MW; 817137E00F08B3F9 CRC64;
MSMLNFIGRG SAFNTEEGNN SAYFVHEGEL ILIDCGSNIF DRLKASRMLD VFKRVRVIIT
HTHPDHIGSL GDLIFYNYFK MGTMGEKDIH VYAPYTLKLG KILQLMGVTT DYYHLHQFDN
NETMSFTHSN IRLTAVPTRH VDELVTYGYL IDRLGTTIYY SGDANRIPHY IMEMLDNDVI
DEFYQDTCAA HYEGNVHLSL HNLALAITSP EIRKKVYCMH LDEGFPIEKV QLMGYNVVEV
S
//
