ID J9VDP1_CRYNH Unreviewed; 989 AA.
AC J9VDP1;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Cation transporter {ECO:0000313|EMBL:AFR92148.2};
GN ORFNames=CNAG_00010 {ECO:0000313|EMBL:AFR92148.2};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR92148.2, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR92148.2, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP003820; AFR92148.2; -; Genomic_DNA.
DR RefSeq; XP_012046149.1; XM_012190759.1.
DR AlphaFoldDB; J9VDP1; -.
DR GeneID; 23883882; -.
DR KEGG; cng:CNAG_00010; -.
DR VEuPathDB; FungiDB:CNAG_00010; -.
DR HOGENOM; CLU_285315_0_0_1; -.
DR OrthoDB; 1358357at2759; -.
DR PHI-base; PHI:7814; -.
DR Proteomes; UP000010091; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR CDD; cd12829; Alr1p-like; 1.
DR Gene3D; 3.30.460.20; CorA soluble domain-like; 1.
DR Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 3.
DR InterPro; IPR044089; Alr1-like.
DR InterPro; IPR045861; CorA_cytoplasmic_dom.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR PANTHER; PTHR21535; MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8; 1.
DR PANTHER; PTHR21535:SF90; TRANSPORTER, PUTATIVE-RELATED; 1.
DR Pfam; PF01544; CorA; 1.
DR SUPFAM; SSF143865; CorA soluble domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 888..909
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 940..962
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..198
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 989 AA; 108976 MW; E563EEBC01302CE2 CRC64;
MPNSNTRTVV AIDYAQTPSR HPHYNSHQTS DSRPSQILTH HTPSARLDLA QPEFAELLTP
LKLRRRKLQP RPDQQPTSLP LVAGPSRLGY YTLEGDLYRG SAHDPTQPPS ANVTAQVDDD
AISLGTGSTT SSTSNWSWGS GNFDRAMAVI ERVGEALGVR RGSAGSSSSD SSADSSDIES
LKSQATAPRK DRKRRGSFMS SLSRQTSRGA EGVKAKHKRE QLPKRRQFTL LVPPPALPSG
DVDIGIPSTI DPHVFAEIGK LPGGRKGDKK YPPDRVIITP SLPTVLDKIQ SIRLSSGYSG
IPNPVGNTPP QTPGAFPSTP TPNLTSRVPV RRGGSAPGRS RKATGFVNPP VPLLPQTQSR
LQCQSQSTAA SRTATQSRLH TLRGAAESIP PVRPKSASDL LGLKFDAESM KEEAPMMERK
VGLEQKGKSK SKGCWWLDVS CPTWEDLREI GELLGLHPLT LEDVLQQDPR EKLERFDKLG
YYFLVIRALD ENYFKYTPGS SISSPSVPSG KNNGKGGNAQ TPKSSPSEKE LIDEKEGLSQ
GINDRSGNNK NEDGNEQRQD IEGLEYKKSE RRRRGWGMGR AQGKMTGKMG EKVEIIEDRP
GKEGLEGVGV GAVNVYLVVF ADGIISFHFE DISKHTSRVL DRVLTLANPD HGADWIAHGL
LDSIVDAFFP IIRYVDGAVD DIDSLTIDPT TDPKKTSAYL GLGLGSVMAG TDEDGNERFK
HGELGSGKKR SGLWRTPDYS LTQHISLRKR LRATFPHFCP PPRLLRTFIY LRLFLLPTSS
AVKRKHDQAS KTLFDRSTML KNMTDMRKLV TGLTRLLSAK GTVIGRLRKR AKEEGGTVEA
YIGDVEDHIL LLQNSLYHYE YILSHCQPAY LSHLNVSFAV TKGRTDQAIL ALSVVAISIL
PMQFITGLFS MNVYVPHNGW IHCPTDTLCE PDGSMSPFNY FAAIVIGIAL VACCMVSVIR
WWRWDARKKF GRLRGVELPN TWDGFWGWE
//
