ID J9VGM0_CRYNH Unreviewed; 1453 AA.
AC J9VGM0;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=DEAH box polypeptide 36 {ECO:0000313|EMBL:AFR92481.2};
GN ORFNames=CNAG_00347 {ECO:0000313|EMBL:AFR92481.2};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR92481.2, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR92481.2, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
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DR EMBL; CP003820; AFR92481.2; -; Genomic_DNA.
DR RefSeq; XP_012046269.1; XM_012190879.1.
DR GeneID; 23884160; -.
DR KEGG; cng:CNAG_00347; -.
DR VEuPathDB; FungiDB:CNAG_00347; -.
DR HOGENOM; CLU_001832_1_3_1; -.
DR OrthoDB; 1095660at2759; -.
DR Proteomes; UP000010091; Chromosome 1.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF197; DEPENDENT RNA HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07950)-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 637..815
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 920..1088
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 859..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..52
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1453 AA; 160393 MW; F8846F6EE2D1CE74 CRC64;
MAKKKLSLKP QNRGFATTSL PKKAAPPSAP PPAHSPPAPP PPALPSSPPP PADWEHEESA
EEVALQGLVD RLQDKAEKEV ARIVKAIEYD RRLAVSFPKL DINQAIRDTA LELALEEEKA
ACQDPDHPPV VTFPSTTVSD SEKGLLRYFI AYHVLQNLGF RQERIEQCLL QGIKEGEGWE
EALEWMWLHL SEDECLQRGE YERATEPSIT ETQESLVPAI GPDVEPIAKP AQSSKPTQTV
LQATGSSTEA RTTAHKSLFQ SQDTSDTESD SGAEDEYHIN EQWAKLQLEL DTLRMASGEG
KKGKKGKGNQ VVLETPEIRR LKDKVSRVEK EYMFTRKNAD AILKALRNQR DVAAIAAKFK
GASMHDANQA ETDSPSENTQ SDSFVGEKTN LMDGSSDEEG DIFGGMLDEP TTLPDTEAET
STSTHITVRS MPIPKQMSFA GTIPKNVLKA ALAKQAKQVV ISYVNLSGAS RAARAGLEIG
WQGGGRKVWK MDDIACDDMV EAENYVSTLA LSDLEAEKTV AGVNWRTMPP SYRELWEELK
VKRKEKEDES RRGIWKMIKG IWDKKAVEAI AEKNDTSKPS TGNTPIDTPA RPAKEKEGVI
IQKLQDDFAK RKESPAYQTM FTQRNTLPIA SFRDQIISTL DTNQILVFSG ETGCGKSTQL
PSFILEDQLA RGKPCKIVVT EPRRISAISL AQRVSQELGD APGAVGTSSS LVGYSIRLES
KTSANTRLSF VTNGIALRML ESGSSGSSRG TAFDEVTHII VDEVHERSIE SDFLLIVLKN
LCEARKDLKV VLMSATVDAE KISAFFGGCP FMSVPGRTFP VTVQYLEDAV ELAGWHIDGS
SPYAIRGKKF KPASQMVEWN EEGAKSDSDP EDEDEETAFN PAKLSSSKYS AQTVDTINIL
DSRIIPYDLI VLLLEKICFE AADYVPFSQA TLVFMPGLAE IRKLNDMLLA HPKFGSTDFV
VWPLHSSISS EGQSAVFKRP PEGARKIVIS TNIAETGVTI PDITCVIDTG KQREMRYDEK
RQLSRFVESY VARSNAKQRR GRAGRVQEGL AFHLFTKARH DTQLPEHPIP EMLRLSLQDL
ALRIKILKVP LGKTVESVLL QALDPPSSIN IQRAIASLVE VKALTPNEEI TPLGRLLSKL
PMDVHLGKFL LVAAMLGCLD PALTIAATLN SKSPFVTPFG FESQARAAKQ SFAIGNNDFF
TIANVFASWR RASDNPHFVR TFCKRNFVSH QNLQQIEELR QQLLAYLIDT SFVDATPAQR
QAISQGRFSR GVRTKFVPVP PELNINGEDL KVVGAALVSG LYPKLLALDG SGGMKTITNQ
QPVAIHPSSV NFKIPKGEFG SNYLAYFTIM HSKRLYAWET GPVDDTALAL LCGDIADFKV
SASSFILDRK IKYCLSPKTS IAIKLIREQF YQVMSLRFRG KKLSDNQQKW FELGLKCLAA
GLQDKEAAKI SVV
//
