ID J9VJ54_CRYNH Unreviewed; 495 AA.
AC J9VJ54;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=SET domain-containing protein 6 {ECO:0000313|EMBL:AFR94467.1};
GN ORFNames=CNAG_05202 {ECO:0000313|EMBL:AFR94467.1};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR94467.1, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR94467.1, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
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DR EMBL; CP003823; AFR94467.1; -; Genomic_DNA.
DR RefSeq; XP_012048781.1; XM_012193391.1.
DR AlphaFoldDB; J9VJ54; -.
DR GeneID; 23888542; -.
DR KEGG; cng:CNAG_05202; -.
DR VEuPathDB; FungiDB:CNAG_05202; -.
DR HOGENOM; CLU_017135_0_0_1; -.
DR OrthoDB; 51002at2759; -.
DR Proteomes; UP000010091; Chromosome 4.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR Gene3D; 3.90.1420.10; Rubisco LSMT, substrate-binding domain; 1.
DR Gene3D; 3.90.1410.10; set domain protein methyltransferase, domain 1; 1.
DR InterPro; IPR015353; Rubisco_LSMT_subst-bd.
DR InterPro; IPR036464; Rubisco_LSMT_subst-bd_sf.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR13271:SF34; N-LYSINE METHYLTRANSFERASE SETD6; 1.
DR PANTHER; PTHR13271; UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE; 1.
DR Pfam; PF09273; Rubis-subs-bind; 1.
DR SUPFAM; SSF81822; RuBisCo LSMT C-terminal, substrate-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 31..276
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 197..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 55935 MW; DC07B1C69968E353 CRC64;
MTSQDPVQAG AFERQKFLTW FKEFGGWYNA ELIDIVSVAG MGYGAVAVKD IEEGTPLFHI
PDDLILSPYT SDLKDHLDAS EWDQLNKGWA QLILVLMWET IKGSKSRWAG YLANMPVTFE
TPMFWTEQQR EQLAGTDIAD RIGREDAEAE YTSVLAPFIK AHPDLFPIDS PHITIDAFHI
QGSRILSRSF TVPLHRFGRS QSQTRSDSNS EMEGDGEEEE EVVVMIPFAD MLNAAWGKDN
AHLYIDEDTN EGFNEGVVMK SIQLVKQSEQ IYNTYDSPPN SELLRKYGHI DVLPLPSDML
DLLNETELGS WPYGNPGDEV LLQGDLIVGC VATKLGGMHM KATLQDRIDW WLDEGQEDIF
PLSFSHDIDD GLISFIRLLL YDLDWNKAHK KGRIPRAIID EAVAGVLHEI INQRLAQYKE
NIDHDLKVVR NSYHGDGNNP VTFLGRNESA AVVRLGEKRI LYLTRRKIAQ ATAGQKSSQK
RKNNSTLMGK GKRMH
//
