ID J9VK33_CRYNH Unreviewed; 895 AA.
AC J9VK33;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Protein transporter {ECO:0000313|EMBL:AFR94827.2};
GN ORFNames=CNAG_01315 {ECO:0000313|EMBL:AFR94827.2};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR94827.2, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR94827.2, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
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DR EMBL; CP003824; AFR94827.2; -; Genomic_DNA.
DR RefSeq; XP_012048979.1; XM_012193589.1.
DR AlphaFoldDB; J9VK33; -.
DR GeneID; 23885043; -.
DR KEGG; cng:CNAG_01315; -.
DR VEuPathDB; FungiDB:CNAG_01315; -.
DR HOGENOM; CLU_323137_0_0_1; -.
DR OrthoDB; 1891044at2759; -.
DR Proteomes; UP000010091; Chromosome 5.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd07627; BAR_Vps5p; 1.
DR CDD; cd06861; PX_Vps5p; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR035803; BAR_Vps5.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR037868; PX_Vps5.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR10555:SF170; FI18122P1; 1.
DR PANTHER; PTHR10555; SORTING NEXIN; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF09325; Vps5; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 514..630
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 806..833
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 7..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 895 AA; 97782 MW; FCA61F20EB355839 CRC64;
MDEEETFANL ISSTALPPRP SWDAPSTSPS HDADPWANPF SADTTTLPTS FSSSALLSSS
PKRTTVSPYV AQLEREATAR SFPDPPSVIA AREQELVQKA EGLAQHRSVY ASSAFASPFE
SPAVNAGPAA DDPFGNPFAQ PSAGQERDPT TVLFPPAPVD ALESPATSDQ TVEQGREILK
NLIDDGLTED GDSGRSLKRA FKKSAQVPRE KREIGSERSK AYVFSPKKKG SKEETKQRVL
KDDIEADKLV EGVEELPLSQ ENALNEGGET EGLGQNQAQE TSTNVPSPTT PKANTPTPRS
PTSVPLPISS VTTPIATRQS TPAPPTENSP VHAKEQIKAG KEKDEASTAT LSTPLSNRVS
VSPLDASSIE EPYKNLSIGS SAPEQIHSSK ATWNTPQSGE SQPSVSTTTT RFGGRGWGAL
DEDDNNGLFG KSTLGIASGS VTGAMSSWGE GEESGWGEPG LASLDESTTL PFDDGSSEPA
SSQPEQEPKP PYASSASSDS ISVATRPTKR PTLPYFQISV SDPTRVGDAV RGYTVYTIRT
RTSSPHYQQS TFSCLRRFSD FLWLFEQLSH NNPGVIVPPM PDKHSWGRFE DQFVETRRLA
LERCLKKITS NPILQLDPDL RLFLESDNFA YESKERKHQI AAQTSSTEKG GLLAGWTGAK
FVEQDDWFNS RRAFLEALES QLKSLGKAIE ISSKHRVELA ISLADYAESL TALAESDLGA
SLSAALSQMS GLVARERDYA EWHAKSEVGE LLNLADEYTR FIGSVRSAFA ARVDSWKVWQ
EKDKEVARMK AAREKARVSG KLGDRVQSSL KEIMEAERRV HEASLEFDRL TKLVKSEFVR
FERERVLEFK ETLERYLNGL IEKEKEMIEG WEGLHSVVAR MMEKSQAGQS VGQQM
//
