ID J9VKM2_CRYNH Unreviewed; 867 AA.
AC J9VKM2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=DNA replication regulator DPB11 {ECO:0000313|EMBL:AFR93164.2};
GN ORFNames=CNAG_03659 {ECO:0000313|EMBL:AFR93164.2};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR93164.2, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR93164.2, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CP003821; AFR93164.2; -; Genomic_DNA.
DR RefSeq; XP_012047166.1; XM_012191776.1.
DR AlphaFoldDB; J9VKM2; -.
DR GeneID; 23887135; -.
DR KEGG; cng:CNAG_03659; -.
DR VEuPathDB; FungiDB:CNAG_03659; -.
DR HOGENOM; CLU_342002_0_0_1; -.
DR OrthoDB; 20296at2759; -.
DR Proteomes; UP000010091; Chromosome 2.
DR GO; GO:0005694; C:chromosome; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR CDD; cd00027; BRCT; 1.
DR CDD; cd17731; BRCT_TopBP1_rpt2_like; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 4.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR PANTHER; PTHR13561; DNA REPLICATION REGULATOR DPB11-RELATED; 1.
DR PANTHER; PTHR13561:SF20; DNA TOPOISOMERASE 2-BINDING PROTEIN 1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF12738; PTCB-BRCT; 2.
DR SMART; SM00292; BRCT; 3.
DR SUPFAM; SSF52113; BRCT domain; 4.
DR PROSITE; PS50172; BRCT; 4.
PE 4: Predicted;
FT DOMAIN 57..128
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 148..258
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 391..481
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 495..578
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..598
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 867 AA; 96654 MW; 2D1E3605E6BC2059 CRC64;
MSNRRGHLSR KIPNAINRPA PPKAHVPRER SPLSRMDLEL LRQAEAEDEE VINHSRQSAR
PWKGVFITFT GVENKAQLSG LARELGAEVD TALTRSITHV IAVSYESPKY QFALANGIPI
MTPAWIIEAH EIWLAGGELD FEEDEENHRL LPFTGFRISM SGIDQMDRRR FLIQLITSHG
GEYSKDLDRD CTHLVSSHPT SDKRRSEKVK WALRENAENE ARRRKGVRDE RDILIVYEEW
IWDCVAYRGR WPSDKYDATK PRRGGKVDPG DVINGTFQIP RPDRKVVINS STAIAGELDA
SEQASVRRRK TAGLDTLVGQ IIGEGKNLDT PKRGASAILE EPTAKRPKPA AKSSMVHLSR
STSFATADVP TSGLPTTNDT EEKVTIDESK HVARIFEGLR MAVCKSKGWE AMLEALSSRG
AILVDEKDWM KGETCNYAII RLANPNIPPM PEGQNTIYVT ENWVESCIVE GKLVSPDEHL
LYKPLTIDVP IPGAKGIIVH ISGSEDHQLS SYHRRLARAL GFELRLTVDR DVTHLISFRN
HGIKVRRAKA WGSQIVTHDW LLKMAETGKL EPEEEYQLHI PPENLRGSRK DSPLTADKVN
RSKADLPVPC DSGVKPEPRL ENRFEAGTSN QNQQTTIQAG PSSIPASRAL RPTPTHVSDS
TDDIFMLDAR ADVSKIQHAD VTLEERSDPL RSSPQSLSRH TSAPAPRSSP FSNKSLTEAD
KRTNMTPSNS AAGTSTFALP NKAASAAALE DMGKKQDISD VLRRLAENPR GTPVNAPRRG
RPSARIKSTN SRSPAIISPS SRPNPQPLHP DYQESMEVED DPMKNFGNDV PEESMQIKYV
DQKAVRERRK LMALFGEESE ASKNKKR
//
