ID J9VKU1_CRYNH Unreviewed; 779 AA.
AC J9VKU1;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 22-FEB-2023, entry version 42.
DE RecName: Full=Actin-related protein 8 {ECO:0000256|RuleBase:RU364121};
GN ORFNames=CNAG_03723 {ECO:0000313|EMBL:AFR93229.1};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR93229.1, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR93229.1, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
CC -!- FUNCTION: Probably involved in transcription regulation via its
CC interaction with the INO80 complex, a chromatin remodeling complex.
CC {ECO:0000256|RuleBase:RU364121}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364121}.
CC -!- SIMILARITY: Belongs to the actin family.
CC {ECO:0000256|RuleBase:RU000487}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP003821; AFR93229.1; -; Genomic_DNA.
DR RefSeq; XP_012047415.1; XM_012192025.1.
DR AlphaFoldDB; J9VKU1; -.
DR GeneID; 23887197; -.
DR KEGG; cng:CNAG_03723; -.
DR VEuPathDB; FungiDB:CNAG_03723; -.
DR HOGENOM; CLU_006974_0_1_1; -.
DR OrthoDB; 11729at2759; -.
DR Proteomes; UP000010091; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.420.40; -; 3.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; ACTIN; 1.
DR PANTHER; PTHR11937:SF13; ACTIN-RELATED PROTEIN 8; 1.
DR Pfam; PF00022; Actin; 2.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU364121};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU364121};
KW Nucleus {ECO:0000256|RuleBase:RU364121};
KW Transcription {ECO:0000256|RuleBase:RU364121};
KW Transcription regulation {ECO:0000256|RuleBase:RU364121}.
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 779 AA; 85349 MW; C7D144978A5A6AFB CRC64;
MDTPASNTEA PPTPSPAPPQ IPSASITTTT SAPAPAVASA PTKKQYNKRV NKKKVEGLLA
YTTAFVPGTY NVKIPAGDYL QKERNADVAR QISLDKARRE EEELSSKIPA AGDGERENPL
SKILVIHPGS RNLRLGLASD FYPKEIPNCI ARPTKAVQIS GARKAPVMGS RVNSLREQHE
RNRKRKRGKV DEDGDHPEED IEMENGDDVG EWVDPIEESI GYLRDYLRNR LVQERLATDW
RELTRIKANN TKVKPELLPE HNDPYRIDWT EPEGKPFFIG TDALRLPESA GYTVRYPILH
RSLNRRDWAS SQTVLDDIST IITSSLSTQL SIAPRDYPLF SVLLIVPDHG DRVYIQEMTH
LILQVLGFKS IAVQQEAYCA IFGAGMSSAC VVDIGAQETS VTCVDEAMLL AETRIKLNYG
GDDITSALTH LLVASNFPYR ELDLARSQDW LMMDNLKIKL CTLEEHLVAN TLWDFYVPRV
EGLTQKWMLR TFDENILAPL VFFDTRMIDF DEKKGQGSFR FWNTSDDKVT DEITSTYEEP
TSAMKALTSH LLPGASQTSV SGFQKSEAPS NSESTTPAPA PLVISSNSSP EKPNASLSTT
LTQTPVPELN LPSTASTPAP TAGGAADAGT PGTAAPALLS LPTLASLAPQ PTLSASQIFT
ASSQSPLDAA IAASLSLCGT ENKIRTLSHS ILLIGGSSSI KGLPAFISDR LPSLLKQRGV
PGNGEVTIVP PPRGLNPKYV CWKGGSVMCN IEGLGDMWIR RDEWEALGVR ALKDRYMWF
//
