ID J9VKW1_CRYNH Unreviewed; 352 AA.
AC J9VKW1;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Guanine nucleotide-binding protein subunit alpha {ECO:0000313|EMBL:AFR92315.1, ECO:0000313|EMBL:AGV15276.1};
GN ORFNames=CNAG_00179 {ECO:0000313|EMBL:AFR92315.1};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR92315.1, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR92315.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H99;
RG The Broad Institute Genomics Platform;
RA Cuomo C., Janbon G.J., Paulet D., Neuveglise C., Dietrich F., Allen A.,
RA Stajich J.S., Heitman J., Kronstad J., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M.D., Poon T., Priest M., Roberts A.D., Saif S., Shea T.D.,
RA Sykes S.N., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Cryptococcus neoformans grubii H99.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AFR92315.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H99 {ECO:0000313|EMBL:AFR92315.1};
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Cuomo C., Gargeya S., Jaffe D., Young S.K., Wortman J., Zeng Q.,
RA Alvarado L., Dietrich F., Allen A., Stajich J.E., Heitman J., Kronstad J.;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AFR92315.1, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 {ECO:0000313|EMBL:AFR92315.1}, and H99 / ATCC 208821 / CBS
RC 10515 / FGSC 9487 {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
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DR EMBL; CP003820; AFR92315.1; -; Genomic_DNA.
DR EMBL; CP003820; AGV15276.1; -; Genomic_DNA.
DR RefSeq; XP_012046585.1; XM_012191195.1.
DR RefSeq; XP_012046586.1; XM_012191196.1.
DR AlphaFoldDB; J9VKW1; -.
DR GeneID; 23884039; -.
DR KEGG; cng:CNAG_00179; -.
DR VEuPathDB; FungiDB:CNAG_00179; -.
DR HOGENOM; CLU_014184_6_0_1; -.
DR OrthoDB; 2897309at2759; -.
DR Proteomes; UP000010091; Chromosome 1.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IEA:InterPro.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR002975; Fungi_Gprotein_alpha.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF355; GUANINE NUCLEOTIDE-BINDING PROTEIN G(O) SUBUNIT ALPHA; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR01241; GPROTEINAFNG.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
SQ SEQUENCE 352 AA; 40198 MW; AF9B49033A692689 CRC64;
MGCTQSTEDV AAKARSAEID EQLKRDRANL RNEIKMLLLG AGESGKSTVL KQMRLIYNKP
YDAEERDSYR EIVYSNTVQS MRVLLEGVQF MDIPIDTSNQ SRWELIMAAP PQIEGDVFPS
KLTDAVAGLW KDYGVQQAFF RRNELQLNDS APYYFDAIAR IAQPNYMPTD QDILRARVKT
TGITETHFKI GELTYKLFDV GGQRSERRKW LNIFDSVTAL VFLIAISEYD QKLYEDESVN
RMQEAMTLFE SVANSRWFTK TSIILFLNKI DIFREKLPVS PLSNTFPEFR GGNDYDMACA
FLLEKFVGLN NSPSKSIYAH YTDATDTKAL KFVISAINDV IIQVNLRDCG LL
//
