ID J9VM30_CRYNH Unreviewed; 646 AA.
AC J9VM30;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Transketolase {ECO:0000313|EMBL:AFR93654.2, ECO:0000313|EMBL:AGV14144.1};
GN ORFNames=CNAG_03040 {ECO:0000313|EMBL:AFR93654.2};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR93654.2, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR93654.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H99 {ECO:0000313|EMBL:AFR93654.2};
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Cuomo C., Gargeya S., Jaffe D., Young S.K., Wortman J., Zeng Q.,
RA Alvarado L., Dietrich F., Allen A., Stajich J.E., Heitman J., Kronstad J.;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AFR93654.2, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 {ECO:0000313|EMBL:AFR93654.2}, and H99 / ATCC 208821 / CBS
RC 10515 / FGSC 9487 {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
RN [3] {ECO:0000313|EMBL:AFR93654.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H99;
RG The Broad Institute Genomics Platform;
RA Cuomo C., Janbon G.J., Paulet D., Neuveglise C., Dietrich F., Allen A.,
RA Stajich J.S., Heitman J., Kronstad J., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M.D., Poon T., Priest M., Roberts A.D., Saif S., Shea T.D.,
RA Sykes S.N., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Cryptococcus neoformans grubii H99.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC Evidence={ECO:0000256|ARBA:ARBA00001941};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the transketolase family.
CC {ECO:0000256|ARBA:ARBA00007131}.
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DR EMBL; CP003822; AFR93654.2; -; Genomic_DNA.
DR EMBL; CP003822; AGV14144.1; -; Genomic_DNA.
DR RefSeq; XP_012047791.1; XM_012192401.1.
DR RefSeq; XP_012048295.1; XM_012192905.1.
DR AlphaFoldDB; J9VM30; -.
DR SwissPalm; J9VM30; -.
DR GeneID; 23886578; -.
DR KEGG; cng:CNAG_03040; -.
DR VEuPathDB; FungiDB:CNAG_03040; -.
DR HOGENOM; CLU_028734_0_0_1; -.
DR OrthoDB; 1691772at2759; -.
DR Proteomes; UP000010091; Chromosome 3.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006163; P:purine nucleotide metabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR033248; Transketolase_C.
DR InterPro; IPR005474; Transketolase_N.
DR PANTHER; PTHR43825; PYRUVATE DEHYDROGENASE E1 COMPONENT; 1.
DR PANTHER; PTHR43825:SF1; TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR Pfam; PF00456; Transketolase_N; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 3: Inferred from homology;
FT DOMAIN 66..265
FT /note="Transketolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00456"
FT DOMAIN 335..438
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|Pfam:PF02779"
FT DOMAIN 519..603
FT /note="Transketolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02780"
SQ SEQUENCE 646 AA; 70881 MW; 019E313C6439623D CRC64;
MSVNKVQGWD FEKFPIDLKK YKPFPLDPTK DKKLSQEQKD GLIANISLLR DVIVFFTATG
AARGLAGHTG GAFDTIPEVV ILLSFLLADQ DKSKYVDILF DEAGHRVATQ YLLSVLDGHL
PVEHLLHYRE ANSKLPGHPE LGFTPGVKFS SGRLGHMWPL VNGVALAEKD KAVFILGSDG
SQQEGDDAEA ARLAVAQGLN VKLFVDDNDV TIAGHPSEYL KGYSVAKTLE GHGLKVVEAN
GEELDSLYSA IVEIMNHKGP AAVVTHRPMA PKIKGIEGSP HAHDAIKVEP AIEYLDARHP
KCAAILRAIQ PSNYAELLSG STKERGACRV QFGEAVSAVL DKSSKEQNKA KVLVIDSDLE
GSTGLSVIHK KHPEVFLSSG IMERGNFSAA AGWGAFNADR QGVFSTFSAF SEMIISELTM
ARLNFANVLT HFSHSGVDEM ADNTCHFGIN QFFLDNGLED GYETRLYFPA DCSQMDAIVD
RVFYDKGLRF VFSTRSKVPW ILKEDGSRFF DSDYKFVPGK DEVIRKGTKG YVVAYGEILY
RALDAVDRLR KEGLDVGLIN KSTLNVVDED VIKEIGSTEF VFVAESLNRK TGLGSKFGTW
LLERDLRPRY NYIGTSKEGC GGLGEQIGHQ NLGSSDIALK VKQMIK
//