ID J9VMP4_CRYNH Unreviewed; 302 AA.
AC J9VMP4;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=GDT1 family protein {ECO:0000256|RuleBase:RU365102};
GN ORFNames=CNAG_02067 {ECO:0000313|EMBL:AFR95752.2};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR95752.2, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR95752.2, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU365102}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU365102}.
CC -!- SIMILARITY: Belongs to the GDT1 family. {ECO:0000256|ARBA:ARBA00009190,
CC ECO:0000256|RuleBase:RU365102}.
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DR EMBL; CP003825; AFR95752.2; -; Genomic_DNA.
DR RefSeq; XP_012049863.1; XM_012194473.1.
DR AlphaFoldDB; J9VMP4; -.
DR GeneID; 23885725; -.
DR KEGG; cng:CNAG_02067; -.
DR VEuPathDB; FungiDB:CNAG_02067; -.
DR HOGENOM; CLU_040186_0_0_1; -.
DR OrthoDB; 180756at2759; -.
DR Proteomes; UP000010091; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR001727; GDT1-like.
DR InterPro; IPR049555; GDT1-like_CS.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR12608:SF1; TRANSMEMBRANE PROTEIN 165; 1.
DR PANTHER; PTHR12608; TRANSMEMBRANE PROTEIN HTP-1 RELATED; 1.
DR Pfam; PF01169; UPF0016; 2.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS01214; UPF0016; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365102};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365102};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365102}.
FT TRANSMEM 14..38
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365102"
FT TRANSMEM 45..69
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365102"
FT TRANSMEM 75..93
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365102"
FT TRANSMEM 200..218
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365102"
FT TRANSMEM 238..260
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365102"
FT TRANSMEM 272..294
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365102"
FT REGION 142..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 302 AA; 32615 MW; 48BB03A94791011C CRC64;
MPEIPNSDST LDGFAQAFVM IVVSEIGDKT FLIAAIMATR HPRMTVFAGA FASLVVMSIL
SAALGRVILG LIPKLWTLWA ASVLFFVFGA KMLQEAFSMA SGSSHIQDEM REVEEELEED
SAVHDSHNAR GTTILLESVE AGAGTRSPRL STSRLDRSAS PRPSRSGPSI HFPLSGGNNV
GPLEKGKHWT MVLKEKIRTT LQMTTNPVFA QAFVLTFLGE WGDRSQITTI AMAGAHSVAV
IAFGTIVGHG ICTCGAVLGG RYLSTKISVK HISLLGAAAF IIFAFLYAIE AYYYNDDLEV
NW
//
