ID J9VQ13_CRYNH Unreviewed; 511 AA.
AC J9VQ13;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=U4/U6 small nuclear ribonucleoprotein PRP4 {ECO:0000313|EMBL:AFR94704.1};
GN ORFNames=CNAG_01439 {ECO:0000313|EMBL:AFR94704.1};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR94704.1, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR94704.1, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
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DR EMBL; CP003824; AFR94704.1; -; Genomic_DNA.
DR RefSeq; XP_012049544.1; XM_012194154.1.
DR AlphaFoldDB; J9VQ13; -.
DR GeneID; 23885153; -.
DR KEGG; cng:CNAG_01439; -.
DR VEuPathDB; FungiDB:CNAG_01439; -.
DR HOGENOM; CLU_000288_57_20_1; -.
DR OrthoDB; 5476798at2759; -.
DR Proteomes; UP000010091; Chromosome 5.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 4.10.280.110; Pre-mRNA processing factor 4 domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR014906; PRP4-like.
DR InterPro; IPR036285; PRP4-like_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19846:SF0; SFM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR19846; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF08799; PRP4; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00500; SFM; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF158230; PRP4-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ribonucleoprotein {ECO:0000313|EMBL:AFR94704.1};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 46..98
FT /note="Pre-mRNA processing factor 4 (PRP4)-like"
FT /evidence="ECO:0000259|SMART:SM00500"
FT REPEAT 170..211
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 262..303
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 304..345
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 346..387
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 87..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..111
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 511 AA; 56452 MW; C9FF7AF8F513F0F5 CRC64;
MDLDDLITDN TYQLGGIDDE RERAQNAAII EELERKKRLR KLAVPTDDKK VRERLRAYGE
PITLFGEGPG DRRDRLKYVQ EQIEQAKGEG GMVVDESDES SDEDEEGEFY TEGSDDLLEA
RRKIARYSLS KARARIARQR REYSVPLGKL VNARKELFKE LKSFNNFGSQ FGDDRPLSTI
RFSPSSQYIL TTSWTGDTKL WDLPNLNPIS TKRGHTEKVG GAAWHPFATV GASEEAVNFA
TGGGEGDVKL WSLSGEKPLS TLSGHTSRVG RLAFHPSGAY LASAGFDGTW RLWDVESSKE
LMTQEGHSKE VYAVGCQDDG ALIASGGFDA IGRVWDLRTG RTAMVLDGHV KEILAMDFAP
NGYQIATGSG DDTVRIWDLR ALKTQYIIPA HKSSVADVKF FRSSGELPPI GIQGLPLSSR
AAEVDGMDVD KSNDTEDKEK EERLSRSGMF LVTAGFDCNV RIWSADEWNM VRNLSTDAGK
VMSVDVSGDG KFVASASYSR SFHLFGGENS L
//
