ID J9VRC7_CRYNH Unreviewed; 633 AA.
AC J9VRC7;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Phytase {ECO:0000313|EMBL:AFR96823.1};
GN ORFNames=CNAG_06967 {ECO:0000313|EMBL:AFR96823.1};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR96823.1, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR96823.1, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
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DR EMBL; CP003827; AFR96823.1; -; Genomic_DNA.
DR RefSeq; XP_012051354.1; XM_012195964.1.
DR AlphaFoldDB; J9VRC7; -.
DR GeneID; 23890108; -.
DR KEGG; cng:CNAG_06967; -.
DR VEuPathDB; FungiDB:CNAG_06967; -.
DR HOGENOM; CLU_020880_2_2_1; -.
DR OrthoDB; 2721627at2759; -.
DR Proteomes; UP000010091; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd07061; HP_HAP_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR033379; Acid_Pase_AS.
DR InterPro; IPR000560; His_Pase_clade-2.
DR InterPro; IPR029033; His_PPase_superfam.
DR PANTHER; PTHR20963; MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR20963:SF42; PUTATIVE-RELATED; 1.
DR Pfam; PF00328; His_Phos_2; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00616; HIS_ACID_PHOSPHAT_1; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 56..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 581..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..609
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..633
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 633 AA; 70830 MW; B0F0A43EE45779A8 CRC64;
MSKPTYSDEP LDAEDYELQA TSNANDPLLP SYSQHPFTSP HQQLQRERSA TRLRSVLSRI
CIAFLIIVPT LAFAACYFGR TTLDKVRTWD SLPPEVQDWL DKIAPAKAHA DHSNFPTDIG
YAGPTPTGSE AALIATAPIL PSHTDVYPLI RPTSKVSKGF SVLQHWGNLS PYYSVDSHGL
PESDSLIPEQ CELESLHWLQ RHGARYPTSY PEGPVALASR LKNAKGWKAR GDLSFLNDWS
YQLGAEILTP FGRSQLFNLG VSARIKYGFL LDKFKDKLPI FRTESQDRML KSAQNFAVGF
FGVPAGDQYN LEVTIEAPGF NNTLAPFTTC RGTGVDYKSK LAEWDSIYLA KAKKRLQENM
QGYNLSFMDV KDMMEMCAYE TVALGHSAFC DLFTQKEWKG FQYRNDIFWW YSSSFGYAPA
KAMGMGWVQE LVSRLTKTRL TEFNSTTNSS FHDDVHFPLG DVLYVDFTHD TQFALLLPTM
NLTTFAETGD LPTDRIPKHR SFVSSKIMPF AANLQVQVLS CSGERKLRLI LNDAPVPLTG
INGCSEDDAG LCPVDTFVAA MKTLIGEIDF AKECALEQET LEEEQELGDE EMAEVKVDGL
EKVEDEEEDR KKGDDDDSDS DSDSDSDSDD DDD
//
