ID J9VSE9_CRYNH Unreviewed; 1332 AA.
AC J9VSE9;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Niemann-Pick C1 protein {ECO:0000313|EMBL:AFR95529.2};
GN ORFNames=CNAG_02298 {ECO:0000313|EMBL:AFR95529.2};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR95529.2, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR95529.2, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP003825; AFR95529.2; -; Genomic_DNA.
DR RefSeq; XP_012049770.1; XM_012194380.1.
DR GeneID; 23885932; -.
DR KEGG; cng:CNAG_02298; -.
DR VEuPathDB; FungiDB:CNAG_02298; -.
DR HOGENOM; CLU_002359_0_1_1; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000010091; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015918; P:sterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 247..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 591..612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 694..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 791..816
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 872..893
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1128..1152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1159..1180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1241..1259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1271..1294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 588..816
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 727..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1332 AA; 146118 MW; 9D91F24564CFA812 CRC64;
MPSSSTQLRS GKGICAMRGT CGKTSMFGAD LPCPDDSDAT VPDQSLLDLM ASVCGPSYSL
PDHVCCTYNQ LSTLSDRLQQ AAPLIASCPA CINNFRSFYC DFTCSPDQST FLSVTATQKT
TEGKDAVKEV DYEVSSDFKQ GFYNSCKDVQ FGATNGFAMD LIGGGATNAS GFLKYMGDLR
PGLGSPFQIN FPDNDDSAYR RAPLSCSDAE DINARCACAD CPSVCPSLPY IAPPSTRQCH
VGAVSCLTFS LLIIYSVIIL VGALLYIWKQ AARHRQRRYE RVALLDPPHS PTIQNGQGSG
LDGLMGRNDD AESGPSGSIH FRLGRGASLL DPMEHLQPKQ NKINATLRRF FYRLGLTCAK
RPIEVFAITA LIVGLLNFGW KYFEVETDPV RLWVSPTSES ASQKRFFDDS FGSFYKSEQV
FITQSSGSPV NYDTLDWWLK VETEINALKT SDGIGLEDIC FAPAGKGTPC VIQSVSAWLG
DDMEVWGEEW ESRVSDCAAR PGECLPPFGQ PIDPKLVLGG ANGDWLKAKA LVVTWVVNNY
NDERVEPAEQ WERKLRDYLG DLKRPGIKIS YSTGVSLEEE INKSTNTDVK IVVLSYLVMF
FYVSLTLGGG LPPSMIQAFA QRAYRLVFRI GVLLHLIKDA PLGETAPPPD FRVIPTLLSV
NSKFSLGLFG IAIVLIAVSS SVGLFSLLGV RVTLIIAEVI PFLVLAVGVD NVFILVHELE
RQNNLHAAQQ PDDDESVHSN GAQPSGTFLA PEERVARAVA RMGPSIMLSS VTEVVAFALG
ALVPMPAVRN FAVYAAGSVL FGAIMQCTVF VSAMTLDLRR SESMRIDCFP CIRLRPPIGL
YDNEAPSREG IVKKFMRTVY APSLLRREVK QLVLVAFGGL FLAAIIGIQH ITLGLDQRLA
LPSESYLVPY FNDVDSFLDV GPPVYFVTEG GDPSSRHGQQ QLCGRFTTCL ELSVANSLEA
ERKRPDSSFI ASPPAAWIDD FLQWTNPTFE SCCRVRRRDP SIFCSPRDSE RLCRPCFEGK
KWDSTMAGLP EGEDFMRYLE QWLISPTNDE CPLGGQAPYS AAVKLASNNT TVAASHFRTY
HTPLKSQADF INALAAARRI SDDITHRTGV KVFPYSLFYV FFDQYEHIIA MAIEVLFLAF
VAVLVITSTL LGSWRTGGTV TFTCALAVIN VMGVMGYWGI SLNAISLVNL VISLGIAVEF
CSHIARAFMG AGSGLPLDKL EGHKERDERT WTALVDVGPS VFSGITMTKL IGISVLALTR
SKLLEVYYFR MWLSLILSGA LHGLVLLPVL LSYLGGQGYP LEDTDEDWVT SQMRRPMDYE
YAPFADTDSL DD
//
