ID J9VT26_CRYNH Unreviewed; 932 AA.
AC J9VT26;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=DNA replication licensing factor MCM2 {ECO:0000256|ARBA:ARBA00018925};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=CNAG_03341 {ECO:0000313|EMBL:AFR96561.1};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR96561.1, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR96561.1, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
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DR EMBL; CP003827; AFR96561.1; -; Genomic_DNA.
DR RefSeq; XP_012051192.1; XM_012195802.1.
DR AlphaFoldDB; J9VT26; -.
DR GeneID; 23886852; -.
DR KEGG; cng:CNAG_03341; -.
DR VEuPathDB; FungiDB:CNAG_03341; -.
DR HOGENOM; CLU_000995_0_1_1; -.
DR OrthoDB; 5476523at2759; -.
DR Proteomes; UP000010091; Chromosome 8.
DR GO; GO:0031261; C:DNA replication preinitiation complex; IEA:UniProt.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0005656; C:nuclear pre-replicative complex; IEA:UniProt.
DR GO; GO:0043596; C:nuclear replication fork; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR GO; GO:0006279; P:premeiotic DNA replication; IEA:UniProt.
DR CDD; cd17753; MCM2; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008045; MCM2.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF44; DNA REPLICATION LICENSING FACTOR MCM2; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF12619; MCM2_N; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01658; MCMPROTEIN2.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 502..708
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 1..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..53
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..99
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 932 AA; 104702 MW; 496501A55BDDC7C1 CRC64;
MPSPSVPPSS QQRPKRPRSR SRSPTAGPSG LRSSPPPSSL PPSSLPPSSP PIPFSDFGDE
QDVADDEAEV RRIGRENGDD DEDEEGEDLF NDDMMADYEE NAGLDTYSQA DLDDRSSVAG
PTRAERLAAE RAMDLRDRGV SGRRAGRRDH MPAFLQSDDD EAEAFGDDPL AGINVRRRRR
QYDERMDEDD VEEDDEEMSL EHLGDVKAAS IAEWVSRDAV RRAISKHFKS FLMTYVDAQG
NSVYGQRIKH LGEVNSESLE VSYIHLANTR PILAYFLANS PQPMLELFDQ VALDAILLYY
PSYDRIHSEI HVRITELPTS LSLRDLRQSN LNCLVRVSGV VTRRSGVFPQ LKYVKFDCQK
CGATLGPFYQ DTNKELKISF CQGCESRGPF VVNSEQTVYR NYQKMTLQES PGSVPAGRLP
RHREVILLWD LIDMAKPGEE VEITGIYRNN FDASLNTKNG FPVFSTVLEA NHINKKEDLF
AAVRLTEEDE KMIRTMARDD RIAKRIVKSI APSIYGHDDI KTAIALSLFG GVGKDINRKH
RIRGDINVLL LGDPGTAKSQ FLKYVEKTAN RAVFTTGQGA SAVGLTASVR KDPITKEWTL
EGGALVLADK GHCLIDEFDK MNDADRTSIH EAMEQQSISI SKAGIITTLQ ARCAIIAAAN
PIRGRYNPTI PFQQNVELTE PILSRFDVLC VVKDAADPVQ DEMLAQFVVG SHLRSHPLFD
KEYEEANVST VVDADIIPQD VLRKYIMYAK EHFRPQLHQL DQDKLARLYA DLRRESLATG
SFPITVRHLE SMIRMAEASA KMHLREYVRT DDIDLAIQVA VGSFVNAQKM SIKKTLERGF
RKYVHQATDH EELLSFLLGG IVKEKVQLYR HSHGENPTRV FVKVSQLEGR AKELEIYDVQ
PFLRSRLFST NGYKVVDHDG ARNIEKTFTV GA
//