ID J9VU17_CRYNH Unreviewed; 777 AA.
AC J9VU17;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 13-SEP-2023, entry version 35.
DE SubName: Full=OPT family small oligopeptide transporter {ECO:0000313|EMBL:AFR96109.2};
GN ORFNames=CNAG_05790 {ECO:0000313|EMBL:AFR96109.2};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR96109.2, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR96109.2, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the oligopeptide OPT transporter family.
CC {ECO:0000256|ARBA:ARBA00008807}.
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DR EMBL; CP003826; AFR96109.2; -; Genomic_DNA.
DR RefSeq; XP_012050374.1; XM_012194984.1.
DR AlphaFoldDB; J9VU17; -.
DR GeneID; 23889080; -.
DR KEGG; cng:CNAG_05790; -.
DR VEuPathDB; FungiDB:CNAG_05790; -.
DR HOGENOM; CLU_004965_1_1_1; -.
DR OrthoDB; 1383663at2759; -.
DR Proteomes; UP000010091; Chromosome 7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035673; F:oligopeptide transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR004648; Oligpept_transpt.
DR InterPro; IPR004813; OPT.
DR NCBIfam; TIGR00728; OPT_sfam; 1.
DR PANTHER; PTHR22601; ISP4 LIKE PROTEIN; 1.
DR PANTHER; PTHR22601:SF80; OPT FAMILY SMALL OLIGOPEPTIDE TRANSPORTER; 1.
DR Pfam; PF03169; OPT; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Peptide transport {ECO:0000256|ARBA:ARBA00022856};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 498..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 586..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 626..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 652..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 697..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 728..757
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 777 AA; 85748 MW; 546246C5C54D0A57 CRC64;
MPINHLEAEA YELPPLSRVA ISPAEHYFDD FVVEEESAKL LDTEGPLKQD DENEPVDDSA
QYMRRTQDEE VIGKGSKVEE LIARTVPSHD DPALPTLTLR VIFLGSSFCI LGACASQIFY
FKSNAPSFSS YFVILATYPL GHLLANERIV PRGKKIFGWE INPGRFSIKE AILISVLSSS
GASSAYAADI LAIMDLYFDT PLSPLPSILL LLTTQCIGFG LAGMLQNLLV NPPAMYWPST
LVTVQLFTTL YSTTSSALSF TQQQLTFTRL RVFLLIFLAT FFYQFLPFLF FPTLTSVSLL
CLVNNRSWWM RTLGSAYQGL GMMDFSFDWS SIGSSGPLYT PYWALGNYFG GLVGMLWVIL
PLLLMLNFWD ARSFPSPVSA GLFNATFQKF DVASILKADL SLDEAAWEEK KPLLLTPHFA
LTYGLSFAAL SSVLVHVWLW HRDEIKQALS NRLQLNDVHN KLMRSYLPVP SAWYVGLLAV
NFGAAVILVK TTPLQMPIWA LVLAMAIATV FLVPVGIIAA VSNTQIGLNV LTEFVAGILM
PGKPIGNVTF KCYGYMAMSQ ALALTADLKL GWYTSIPPRE MFTCQIIGTV LGALTNYATL
VSVMAAKKPY LNGSLTDPTG QWTGRAPSIF YSASIIWGAV APARFFSDGY EVLYLGFLVG
ALLPVGFWLA HKKWPGYKLN KVVFPIICSG ATVVPQYPSN IILTSLLTAV LVNSWFAKRH
PKSHSQYVYV ASSALDAGTS ITALAIYVLF GGVFWNWNGW DWWGNSMVDS EHCVPGS
//
