ID J9VUC5_CRYNH Unreviewed; 4629 AA.
AC J9VUC5;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=CNAG_05894 {ECO:0000313|EMBL:AFR96214.1};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR96214.1, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR96214.1, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
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DR EMBL; CP003826; AFR96214.1; -; Genomic_DNA.
DR RefSeq; XP_012050613.1; XM_012195223.1.
DR GeneID; 23889178; -.
DR KEGG; cng:CNAG_05894; -.
DR VEuPathDB; FungiDB:CNAG_05894; -.
DR HOGENOM; CLU_000038_7_0_1; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000010091; Chromosome 7.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF23; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1931..2069
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2598..2748
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2940..3106
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 3202..3264
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3420..3468
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4629 AA; 523644 MW; 8E64AAB4302E1561 CRC64;
MTMASSQLED GALIPPSTTG GLVFDVAVFR TYLQSLLPLV MSATPQELED SLFEDPNFDE
KTVRFATDAS CQVVYITRER YLDVDEDGIP TARITYRLHL PPTPPHSPNT LSTLALIKTS
PTIDSLNPLG TQLHFLQLSS AFTAPTLVED DGTPSGMTTA VATPTVSASA QATPYDGLHS
LVHWGVAPWF DSYVSSKQSL IPGHGAHDGL GKKGGEAQMG IPVTKKKFAE LELSLLHLKQ
NVEIPEVHLS VHPAIRKAVA HCNATNQRVS PDAVEPQSLL SDPSFLNKLQ ADVNSWIKEI
QAVTKLNRDV ASGTASQEIN FWISMEHALE GIEQQLGGEE VTLVLDVLKH AKRFHATVSF
IADTGLKEAA DLVHKHNILM KDFPLDELLA ATDLEKIQDA IYLIFAHINK KLKLSPYPIR
RTLPLVEAIS SDFNDQLLKV LSSQRLMYMD YTKFEEVMAT AAEVFGTWDE NMKDFTNVAR
EVSRKRAEKF ISIKINPIHA KLQERITYLR AFRRSHEQLR VMTSSTRSFS GLGNDVPFDI
DMEEEVRLSY ENVKNVDVLD VSPEGSEIWY TAETAYNDRV ARIENQIISR LRDKLATARN
AQEMFRVFSK FNTLFVRPKI RGAIQEYQTR LIESVKEDIH RLRQKFTENY RNSQAYHMSQ
MRDFPSVSSA IIWARQIERQ LLTYMKRVED VLGKGWESYA EGHKLQMESA SFRVKLDTRP
LYDAWISDIT KRGNLTITGR LFDVIRTRAT ATNAQGQLQL VVQFDPQVIA LFKEVRSLIW
LGFPVPLTIS HKAKDAKRVY PHAVSLMESV KTYTQTLDLI ERNPEVAILL ARYRSHALQM
IERGIKMQWD HLVNAYEGHR FLPGSVTDSR ESRHFLFVRE FASVVSLLQD KANALIEIHT
DINRVVEELA ICEYNSDTFS SLLGQIQKTI DHLNLENYSN LDAWVATLNE KIDKVLSERL
INAIEIWCAE FGKDEEAAGG DVAVAGGNGS RGDMNIEPLV HEIRIRNQVI YLDPPIELAR
QEWLGQFQDA LGVICNLCRI RSSRYEISLQ AEEASLEETT YIGLLTSFAD GTLEKPLALI
EDKVQTVSSY VNKWLQFQSL WDLEAEYVYN RLGDSLADWG QLLSDIRQTR STFDTADTKK
DFGVCVIDYA NAQSKVNAKY DSWQRELLAR YGAKLGVSMK DTYNAILKAR TELEGLAIEG
SSTARAVSFI TFVQDLKRKV QKWGPEIEEF DRGQKTLERQ RYSFPADWLY IDQIQGEWGA
FSEILKRKDD SIKEQVAGLQ LKIVAEDKVI DQRIRDFIAE WEENKPLQGS IKAETAINTL
NVFEGRLARL LEEYNLVCRA KEALDLEHAN DDRLQPVNEE LRDLKAVWTA LSGIWGRLAQ
LRETLWTAVQ PRKLRQELDA ILSSTRDMPS RMRQYAAFEY VQDTIKTLLK SNILIGELKS
EALRERHWSK LYKALRMPTQ QTSLMTLDQV YNLDLKRNEV LIKEVVAQAQ GEMALEEFIK
QVKETWTSYS LDLINYQNKC RLIRSWDDLF NKCGEHLNSL TAMRMSPYYR IFEEDAASWE
DKLNRIHVLF DVWIDVQRQW VYLEGIFSGS ADIKHLLPVE STRFQNINSE FLIVMKRVNK
SPFVLDVLNI PGIQKNLERL ADLLTKIQKA LGEYLEKERS SFPRFYFVGD EDLLEIIGNS
KDTRRIMKHL KKMFAGISTL QMDEEETQLL GFSSREGEEV YFRTPIVLKD FPKINDWLAK
VESEMRISLA YLLSQAVTEL NGFFKVDTSL SLDDLLAWTG SYPAQLVVLA VQVAWTNLVE
SSIATAGLTS VLALVSQTLD LLADTVLQDI AVLQRRKCEH LITELVHQRD VIRSLITSGT
RSTTTFDWLY HMRFYLNESV SDPLLKLEIR MADAVFPYGY EYLGIPDRLV QTPLTDRCYL
TLTQALGNQF GGSPFGPAGT GKTESVKSLG VQLGRFVLVF CCDETFDFQA MGRIFIGLCQ
VGAWGCFDEF NRLEERILSA VSQQVQSIQQ GLAHVASNPD AEVELVGKKL KINSRTGIFI
TMNPGYAGRS NLPDNLKKLF RSMAMTRPDQ ELIAQVLLFS KGFRTAEVLA SKVVPFFNLC
AEQLSDQPHY DFGLRALKSV LASAGILKRD RHLALEQGDG IDSGTDGFVE QQIMIQSVTE
TIVPKLVADD VPLLKALLED VFPGIEYVPV NLDALKAKLD EVCKERHLIA KESWLEKVVQ
LYQIQNISHG LMMVGPSGSG KTQAWQVLLA ALERLDGIEG ASYVIDPKAI DKEALYGTLD
ATTREWNDGL FTHILRKIVD NVRGETAKRH WIIFDGDVDP EWVENLNSVL DDNKLLTLPN
GERLNLPPNV RIMFEVEHLR YATLATVSRC GMIWFSEDVI DTSMIYNHHL DMIAVLPIGT
DEDETLDYAT GVDSDTVASR HLEVQRQIVD MLKPHFQQEG LVNKALEYAA KSEHIMEFTS
ARALNTLFSL LKATIRHVLE YNTCHSDFPL STEKVEAYVL RRLLLNIIWA FVGDAKLDIR
AEMGKQLVLE SGIETPPLGP GASLIDYDVD VSSADWVAWQ SRVPTIEVET HAITSADVVI
PTIDTVRHEE VLYSWLAEHK PLILCGPPGS GKTMTLFSAL RKLPDLEVVG LNFSSATTPE
LILKTFEQYC EYRKTPNGVI LAPTQIGRWL VVFCDEINLP ATDKYGTQRV ISFLRQLMEC
NGFWRTSDLS WVKMERIQFV GACNPPTDPG RVPLNHRFMR HAPVVMVDYP GEVSLKQIYG
TFNRALLKVI PILRGHSDAL TDAMVSFYLA SQKRFTADIQ AHYIYSPREL TRWSRGIYEA
IKPLETLSVE GLLRVWAHEA LRLFQDRLVA EEEKQWTDDL IDATVSEYFP SVDVSDALAR
PILFSNWTSR NYIPVNREQL REYTKARLKV FYEEELDVQL VLFNDVLDHV LRIDRVFRQI
QGHLLLIGVS GGGKTTLSRF VAWMNGLSIY QIKVSNKYTG ADFDEDLRTV LRRAGCKGEK
ICFIMDESNV LDSGFLERMN TLLANAEVPG LFEGDEYAAL MTACKEGSQR DGLMLDSHEE
LYRWFTQQVA RNLHVVFTMN PPANGLASRA ATSPALFNRC VLDWFGDWSD QALYQVGLEF
TQTLDLDMAS YVPGASFPTI YRDLPVPPSH RQAVVNAMVY VHQSMQSLTT KLAKRQGKYN
HVTPRHFLDF INHYVRLFNE KKEDLEEQQR HLNVGLDKLR ETVSQVEELR HSLAAKSSQL
EEKNDEANQK LKQMVTDQQE AEAKKAASID IQAALERQDE FIRQRQEVVK EDLALAEPAV
LEALAAVGNI KKQHLSEVRS MANPPEAVKM AMESACTVLG HQIDSWRTVQ GIIRREDFIS
SIQNFDTKKM SKTVRDRMNR DYISKPTFNF ETVNRASRAC GPLVQWVIAQ VRYSEILEKV
APLRQEVASL EKQADATKQQ VQVAMDTIAE LESSIDRYKE EYALLISETQ SIKSEMDRVQ
TKVDRSMTLL QSLSSEQERW DTGSKTFETE MGTIVGDVMV SAAFLAYSGF FGQHYRDLMK
REWMDHLSEA GISYKHDLAL SEFLSTADER LGWQANALPA DNLCIENAVM LKRYNRYPLI
VDPTGQATAF LQNEYRDRKI TITSFLDESF LKKLESALRF GNPLLIQDVE NLDPILNSVL
NRELRRTGGR VLIRIGNQDI DFSPAFTMFL STRDPSVEFS PDICSRVTFV NFTMTRSSLQ
TQALDKVLKA ERPKVDQKRT DLMKLQGEFR LRLNHLERSL LQALNESTGS ILDDDKVIGT
LEVLKKEAAE ITRKVEDTEI VMREVEAVTE EYQPLAQACS GIYFTLEQLA SINHFYQFSL
DYFLEIFDYV LLRNPRLKGV SDMETRKSIL LQDIFLTAFQ RTSRSLLHTD YLVLSVTLAK
LRLRGEEGAK VLQELDAVLD VPSGGMARDL KLTMEQKKSL DGILDGEMSK VLEQDLINNE
GRWRLFMAAT QPEKDVPWPW SEGNALFTAA RRMLVIKIFR PDRLLQSMTI FADLAFDIDL
AVQADYDVQA VVTEQVGPTH PVAFVSVPGY DASYRVENLC RSMGVNCTSV ALGSAEGFTL
ADQAIAEAAR TGSWVLLKNV HLAPGWLAQL EKRLHSLSPN HNFRLFLTME TNPVIPVNIL
RQSRIIMNEP APGVRANLLD TLRGIPQSLS SSGPAERPRL FFLLAWFHSV VQERLRYLPL
GWSKSYEFND SDFDAALNTI NSWITALAKG KANVDPVQIP WVAIRTLIKQ AVYGGRVDSD
YDQRVVDAFV DKIFTPRAYD PDFKLVELDE GQPGLSIPEG TQMSHFIEWA HGLPEREPPS
WLSLPPTAEG VVAAAEGDAT MVKLRKMRTT EDDEDDGDPV SGASLGRPAW MTALKSHADV
WLSALPEALS STPHEPSHAH SPLSRFFVRE ASTGSKLLKR IRHDLFDLIQ VCLGNLKQTN
ELRALMSDLN RGTVPAHWCK FKMPRGTAVS QYINNLAARL AQLERLANGA VEAQQGVWLG
GLFQPEAYIT ATRQAVAHDR GWSLEQLVLG MDISQTGGQD AFAVQGLTLQ GASWACGRLQ
LNEGQSILLP PSQLTWRRHD EAPQTSGTTM VNLPVYLNGD RSDVLFSVDL EADEGDDVIA
QRGVCLTAA
//