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Database: UniProt
Entry: J9VUC5_CRYNH
LinkDB: J9VUC5_CRYNH
Original site: J9VUC5_CRYNH 
ID   J9VUC5_CRYNH            Unreviewed;      4629 AA.
AC   J9VUC5;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   24-JAN-2024, entry version 56.
DE   RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE   AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN   ORFNames=CNAG_05894 {ECO:0000313|EMBL:AFR96214.1};
OS   Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS   CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR96214.1, ECO:0000313|Proteomes:UP000010091};
RN   [1] {ECO:0000313|EMBL:AFR96214.1, ECO:0000313|Proteomes:UP000010091}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC   {ECO:0000313|Proteomes:UP000010091};
RX   PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA   Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA   Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA   Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA   Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA   Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA   Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA   Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA   Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA   Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA   Cuomo C.A., Dietrich F.S.;
RT   "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT   grubii reveals complex RNA expression and microevolution leading to
RT   virulence attenuation.";
RL   PLoS Genet. 10:E1004261-E1004261(2014).
CC   -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC       intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
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DR   EMBL; CP003826; AFR96214.1; -; Genomic_DNA.
DR   RefSeq; XP_012050613.1; XM_012195223.1.
DR   GeneID; 23889178; -.
DR   KEGG; cng:CNAG_05894; -.
DR   VEuPathDB; FungiDB:CNAG_05894; -.
DR   HOGENOM; CLU_000038_7_0_1; -.
DR   OrthoDB; 312195at2759; -.
DR   Proteomes; UP000010091; Chromosome 7.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   CDD; cd00009; AAA; 2.
DR   Gene3D; 1.10.287.2620; -; 1.
DR   Gene3D; 1.10.472.130; -; 1.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.1270.280; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 2.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041466; Dynein_AAA5_ext.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR013594; Dynein_heavy_tail.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR   PANTHER; PTHR45703:SF23; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08385; DHC_N1; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF17852; Dynein_AAA_lid; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SMART; SM00382; AAA; 3.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR   SUPFAM; SSF57997; Tropomyosin; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1931..2069
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2598..2748
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2940..3106
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   COILED          3202..3264
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3420..3468
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   4629 AA;  523644 MW;  8E64AAB4302E1561 CRC64;
     MTMASSQLED GALIPPSTTG GLVFDVAVFR TYLQSLLPLV MSATPQELED SLFEDPNFDE
     KTVRFATDAS CQVVYITRER YLDVDEDGIP TARITYRLHL PPTPPHSPNT LSTLALIKTS
     PTIDSLNPLG TQLHFLQLSS AFTAPTLVED DGTPSGMTTA VATPTVSASA QATPYDGLHS
     LVHWGVAPWF DSYVSSKQSL IPGHGAHDGL GKKGGEAQMG IPVTKKKFAE LELSLLHLKQ
     NVEIPEVHLS VHPAIRKAVA HCNATNQRVS PDAVEPQSLL SDPSFLNKLQ ADVNSWIKEI
     QAVTKLNRDV ASGTASQEIN FWISMEHALE GIEQQLGGEE VTLVLDVLKH AKRFHATVSF
     IADTGLKEAA DLVHKHNILM KDFPLDELLA ATDLEKIQDA IYLIFAHINK KLKLSPYPIR
     RTLPLVEAIS SDFNDQLLKV LSSQRLMYMD YTKFEEVMAT AAEVFGTWDE NMKDFTNVAR
     EVSRKRAEKF ISIKINPIHA KLQERITYLR AFRRSHEQLR VMTSSTRSFS GLGNDVPFDI
     DMEEEVRLSY ENVKNVDVLD VSPEGSEIWY TAETAYNDRV ARIENQIISR LRDKLATARN
     AQEMFRVFSK FNTLFVRPKI RGAIQEYQTR LIESVKEDIH RLRQKFTENY RNSQAYHMSQ
     MRDFPSVSSA IIWARQIERQ LLTYMKRVED VLGKGWESYA EGHKLQMESA SFRVKLDTRP
     LYDAWISDIT KRGNLTITGR LFDVIRTRAT ATNAQGQLQL VVQFDPQVIA LFKEVRSLIW
     LGFPVPLTIS HKAKDAKRVY PHAVSLMESV KTYTQTLDLI ERNPEVAILL ARYRSHALQM
     IERGIKMQWD HLVNAYEGHR FLPGSVTDSR ESRHFLFVRE FASVVSLLQD KANALIEIHT
     DINRVVEELA ICEYNSDTFS SLLGQIQKTI DHLNLENYSN LDAWVATLNE KIDKVLSERL
     INAIEIWCAE FGKDEEAAGG DVAVAGGNGS RGDMNIEPLV HEIRIRNQVI YLDPPIELAR
     QEWLGQFQDA LGVICNLCRI RSSRYEISLQ AEEASLEETT YIGLLTSFAD GTLEKPLALI
     EDKVQTVSSY VNKWLQFQSL WDLEAEYVYN RLGDSLADWG QLLSDIRQTR STFDTADTKK
     DFGVCVIDYA NAQSKVNAKY DSWQRELLAR YGAKLGVSMK DTYNAILKAR TELEGLAIEG
     SSTARAVSFI TFVQDLKRKV QKWGPEIEEF DRGQKTLERQ RYSFPADWLY IDQIQGEWGA
     FSEILKRKDD SIKEQVAGLQ LKIVAEDKVI DQRIRDFIAE WEENKPLQGS IKAETAINTL
     NVFEGRLARL LEEYNLVCRA KEALDLEHAN DDRLQPVNEE LRDLKAVWTA LSGIWGRLAQ
     LRETLWTAVQ PRKLRQELDA ILSSTRDMPS RMRQYAAFEY VQDTIKTLLK SNILIGELKS
     EALRERHWSK LYKALRMPTQ QTSLMTLDQV YNLDLKRNEV LIKEVVAQAQ GEMALEEFIK
     QVKETWTSYS LDLINYQNKC RLIRSWDDLF NKCGEHLNSL TAMRMSPYYR IFEEDAASWE
     DKLNRIHVLF DVWIDVQRQW VYLEGIFSGS ADIKHLLPVE STRFQNINSE FLIVMKRVNK
     SPFVLDVLNI PGIQKNLERL ADLLTKIQKA LGEYLEKERS SFPRFYFVGD EDLLEIIGNS
     KDTRRIMKHL KKMFAGISTL QMDEEETQLL GFSSREGEEV YFRTPIVLKD FPKINDWLAK
     VESEMRISLA YLLSQAVTEL NGFFKVDTSL SLDDLLAWTG SYPAQLVVLA VQVAWTNLVE
     SSIATAGLTS VLALVSQTLD LLADTVLQDI AVLQRRKCEH LITELVHQRD VIRSLITSGT
     RSTTTFDWLY HMRFYLNESV SDPLLKLEIR MADAVFPYGY EYLGIPDRLV QTPLTDRCYL
     TLTQALGNQF GGSPFGPAGT GKTESVKSLG VQLGRFVLVF CCDETFDFQA MGRIFIGLCQ
     VGAWGCFDEF NRLEERILSA VSQQVQSIQQ GLAHVASNPD AEVELVGKKL KINSRTGIFI
     TMNPGYAGRS NLPDNLKKLF RSMAMTRPDQ ELIAQVLLFS KGFRTAEVLA SKVVPFFNLC
     AEQLSDQPHY DFGLRALKSV LASAGILKRD RHLALEQGDG IDSGTDGFVE QQIMIQSVTE
     TIVPKLVADD VPLLKALLED VFPGIEYVPV NLDALKAKLD EVCKERHLIA KESWLEKVVQ
     LYQIQNISHG LMMVGPSGSG KTQAWQVLLA ALERLDGIEG ASYVIDPKAI DKEALYGTLD
     ATTREWNDGL FTHILRKIVD NVRGETAKRH WIIFDGDVDP EWVENLNSVL DDNKLLTLPN
     GERLNLPPNV RIMFEVEHLR YATLATVSRC GMIWFSEDVI DTSMIYNHHL DMIAVLPIGT
     DEDETLDYAT GVDSDTVASR HLEVQRQIVD MLKPHFQQEG LVNKALEYAA KSEHIMEFTS
     ARALNTLFSL LKATIRHVLE YNTCHSDFPL STEKVEAYVL RRLLLNIIWA FVGDAKLDIR
     AEMGKQLVLE SGIETPPLGP GASLIDYDVD VSSADWVAWQ SRVPTIEVET HAITSADVVI
     PTIDTVRHEE VLYSWLAEHK PLILCGPPGS GKTMTLFSAL RKLPDLEVVG LNFSSATTPE
     LILKTFEQYC EYRKTPNGVI LAPTQIGRWL VVFCDEINLP ATDKYGTQRV ISFLRQLMEC
     NGFWRTSDLS WVKMERIQFV GACNPPTDPG RVPLNHRFMR HAPVVMVDYP GEVSLKQIYG
     TFNRALLKVI PILRGHSDAL TDAMVSFYLA SQKRFTADIQ AHYIYSPREL TRWSRGIYEA
     IKPLETLSVE GLLRVWAHEA LRLFQDRLVA EEEKQWTDDL IDATVSEYFP SVDVSDALAR
     PILFSNWTSR NYIPVNREQL REYTKARLKV FYEEELDVQL VLFNDVLDHV LRIDRVFRQI
     QGHLLLIGVS GGGKTTLSRF VAWMNGLSIY QIKVSNKYTG ADFDEDLRTV LRRAGCKGEK
     ICFIMDESNV LDSGFLERMN TLLANAEVPG LFEGDEYAAL MTACKEGSQR DGLMLDSHEE
     LYRWFTQQVA RNLHVVFTMN PPANGLASRA ATSPALFNRC VLDWFGDWSD QALYQVGLEF
     TQTLDLDMAS YVPGASFPTI YRDLPVPPSH RQAVVNAMVY VHQSMQSLTT KLAKRQGKYN
     HVTPRHFLDF INHYVRLFNE KKEDLEEQQR HLNVGLDKLR ETVSQVEELR HSLAAKSSQL
     EEKNDEANQK LKQMVTDQQE AEAKKAASID IQAALERQDE FIRQRQEVVK EDLALAEPAV
     LEALAAVGNI KKQHLSEVRS MANPPEAVKM AMESACTVLG HQIDSWRTVQ GIIRREDFIS
     SIQNFDTKKM SKTVRDRMNR DYISKPTFNF ETVNRASRAC GPLVQWVIAQ VRYSEILEKV
     APLRQEVASL EKQADATKQQ VQVAMDTIAE LESSIDRYKE EYALLISETQ SIKSEMDRVQ
     TKVDRSMTLL QSLSSEQERW DTGSKTFETE MGTIVGDVMV SAAFLAYSGF FGQHYRDLMK
     REWMDHLSEA GISYKHDLAL SEFLSTADER LGWQANALPA DNLCIENAVM LKRYNRYPLI
     VDPTGQATAF LQNEYRDRKI TITSFLDESF LKKLESALRF GNPLLIQDVE NLDPILNSVL
     NRELRRTGGR VLIRIGNQDI DFSPAFTMFL STRDPSVEFS PDICSRVTFV NFTMTRSSLQ
     TQALDKVLKA ERPKVDQKRT DLMKLQGEFR LRLNHLERSL LQALNESTGS ILDDDKVIGT
     LEVLKKEAAE ITRKVEDTEI VMREVEAVTE EYQPLAQACS GIYFTLEQLA SINHFYQFSL
     DYFLEIFDYV LLRNPRLKGV SDMETRKSIL LQDIFLTAFQ RTSRSLLHTD YLVLSVTLAK
     LRLRGEEGAK VLQELDAVLD VPSGGMARDL KLTMEQKKSL DGILDGEMSK VLEQDLINNE
     GRWRLFMAAT QPEKDVPWPW SEGNALFTAA RRMLVIKIFR PDRLLQSMTI FADLAFDIDL
     AVQADYDVQA VVTEQVGPTH PVAFVSVPGY DASYRVENLC RSMGVNCTSV ALGSAEGFTL
     ADQAIAEAAR TGSWVLLKNV HLAPGWLAQL EKRLHSLSPN HNFRLFLTME TNPVIPVNIL
     RQSRIIMNEP APGVRANLLD TLRGIPQSLS SSGPAERPRL FFLLAWFHSV VQERLRYLPL
     GWSKSYEFND SDFDAALNTI NSWITALAKG KANVDPVQIP WVAIRTLIKQ AVYGGRVDSD
     YDQRVVDAFV DKIFTPRAYD PDFKLVELDE GQPGLSIPEG TQMSHFIEWA HGLPEREPPS
     WLSLPPTAEG VVAAAEGDAT MVKLRKMRTT EDDEDDGDPV SGASLGRPAW MTALKSHADV
     WLSALPEALS STPHEPSHAH SPLSRFFVRE ASTGSKLLKR IRHDLFDLIQ VCLGNLKQTN
     ELRALMSDLN RGTVPAHWCK FKMPRGTAVS QYINNLAARL AQLERLANGA VEAQQGVWLG
     GLFQPEAYIT ATRQAVAHDR GWSLEQLVLG MDISQTGGQD AFAVQGLTLQ GASWACGRLQ
     LNEGQSILLP PSQLTWRRHD EAPQTSGTTM VNLPVYLNGD RSDVLFSVDL EADEGDDVIA
     QRGVCLTAA
//
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