ID J9VVV9_CRYNH Unreviewed; 846 AA.
AC J9VVV9;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Enhancer of polycomb-like protein {ECO:0000256|RuleBase:RU361124};
GN ORFNames=CNAG_06364 {ECO:0000313|EMBL:AFR98602.1};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR98602.1, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR98602.1, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. Involved in gene silencing by neighboring
CC heterochromatin, blockage of the silencing spreading along the
CC chromosome, and required for cell cycle progression through G2/M.
CC {ECO:0000256|ARBA:ARBA00025513}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU361124}.
CC -!- SIMILARITY: Belongs to the enhancer of polycomb family.
CC {ECO:0000256|ARBA:ARBA00008035, ECO:0000256|RuleBase:RU361124}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP003832; AFR98602.1; -; Genomic_DNA.
DR RefSeq; XP_012053443.1; XM_012198053.1.
DR AlphaFoldDB; J9VVV9; -.
DR GeneID; 23889575; -.
DR KEGG; cng:CNAG_06364; -.
DR VEuPathDB; FungiDB:CNAG_06364; -.
DR HOGENOM; CLU_336162_0_0_1; -.
DR OrthoDB; 1343374at2759; -.
DR Proteomes; UP000010091; Chromosome 13.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR024943; Enhancer_polycomb.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR PANTHER; PTHR14898; ENHANCER OF POLYCOMB; 1.
DR PANTHER; PTHR14898:SF0; ENHANCER OF POLYCOMB-LIKE PROTEIN; 1.
DR Pfam; PF10513; EPL1; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361124};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361124};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361124}.
FT DOMAIN 15..224
FT /note="Enhancer of polycomb-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10513"
FT REGION 169..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..450
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 846 AA; 95281 MW; C63AA126BC50D369 CRC64;
MVAPGRMVTS SRRIGRVTNK TKLIIYRGSD KVDTSAAETV LWDQEAGGAG KDSNKHQHIG
ATGVESGELL EHHLQAALSS ASLLHSNNKP PSPKSVKEAP AAALNYHIPT PDATGLVSDT
VFSQLYQRTK YVEPYNFIRF SDTVEESSCG WGGLGYCMDD ADERWLNDFN SKAEGSSGDV
KSDKEQGRGM RVKGKDKEKE KGDAPAPLVI SEDMFEYIMG VFEKYTEENA PMLHTDLSLL
PPFSAVESMF STPISPAFLP SNETPKELGD LKACARMARN VYPHWKSRRE QRQGKSILPQ
LNYDETNDND PYVCFRRRDI RATRKTRRTD NFSIEQFQKL QFELRSAYAL ADRVLTRERE
KRSLYEAEKE LWEARWKLFE TKRRWPSLGM TNDEEHKITG RPTVVPPIQI PSLSGQTPLT
SGQSSSHMRK RTDKDREERA QRERYDAQRN AERSGVLSGR SNAPDALKER LQALQQKTEE
MLARKKEQDA YWDDSTDSPY QPLPPSNSVH AFRSLFVLDP CRAQCKDSET GNEILHPESF
RIRRGRGGIV RLDRRTSIYA HRRGIQPASP SEYPTWLFPD IAPRRSEKKR PRSIDEVEEE
MREQSPKAMR KDLNETWRYD VDRGGAVGVG MGLEEDYDRV IIDDLEAKYI RHRISLLQES
DCAKLRPDNY ILDQTREALD VAADAKPPPA PIFQKPPAPQ PNPQLLAAHL QQQQMLAQQQ
QMEQFQRFQL MAQQQAMAQA QAQAQAQAQA QAQAQAQAQV QAQGQGHPQA HLQTHPPGVP
QPNGVNSPMP NGQQMLPPSD GVAKQLKLPP HAVARLGAAM ANANANANGG LHVLQQQQQH
AQTSQQ
//
