ID J9VXN4_CRYNH Unreviewed; 674 AA.
AC J9VXN4;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 22-FEB-2023, entry version 38.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
GN ORFNames=CNAG_01982 {ECO:0000313|EMBL:AFR98176.2};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR98176.2, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR98176.2, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
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DR EMBL; CP003830; AFR98176.2; -; Genomic_DNA.
DR RefSeq; XP_012052524.1; XM_012197134.1.
DR AlphaFoldDB; J9VXN4; -.
DR GeneID; 23885646; -.
DR KEGG; cng:CNAG_01982; -.
DR VEuPathDB; FungiDB:CNAG_01982; -.
DR HOGENOM; CLU_407690_0_0_1; -.
DR OrthoDB; 3030820at2759; -.
DR Proteomes; UP000010091; Chromosome 11.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00159; RhoGAP; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR45808; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR PANTHER; PTHR45808:SF2; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
FT DOMAIN 362..554
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 69..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 674 AA; 73097 MW; 0B3AECE706DE2EEA CRC64;
MDQANAPSTS PINTPATVLH RPTLANPSQQ PPPAPPLSSS NTDKETASIM GLVARGGKEV
WRRSLGALWT SESGPKDDGS SRSSRRASVD SALSTGSRTK SLHRTQSVDT SSILYPTLTV
HPPPVPHNIL IVSLAHVPSA PPTLSNDELF QIVLRRLEPW VGEEGEGGYV LIILSAEGLL
GGKMAFDVKH KAEARKLPGV AWWIWKWKRL PHKYRKNVKR FYIVHPSYFT RSLLPFIVPL
LSPKSYSKLY PVPSLLALYY EHGVTLKGID ITLPVLEAES QALKDDPELL SFALTLSQVP
LGEDSRPMFK RSSNSQSSSL WGFQALSSVV STAASYVGLP RTSFNDAAER RRVVASEGYW
KRDLTALVDE CGGKVPPLLL SLGKVILSAG ISTEGIFRRA PHSRHLEPLV ALLALPLEDQ
GNPSWSQLAL ADPLLPPKIL CKFLAELASP ILRSELYDVI RSIVEPGDIK ERLFPRLPPS
HIVILHCVIY ILHRLTAFKD STKMNALNLA IVVAPTLISG PDRLEDASMC LEPGKKLPLA
MLVAAGKAPE ESIKGKEVEM SGQGTVVGML ELWIREYPYV SGDLVPERMV CPVSSAGVAA
AAKRKEAGEH QSIWERESYP KARKRRSGSV RNSFLGTLFA GSGGNKEGNG MGEVVEVREG
IVGGPSSGSG SSPG
//
