ID J9VXV8_CRYNH Unreviewed; 1087 AA.
AC J9VXV8;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Phospholipid binding protein {ECO:0000313|EMBL:AFR96540.2};
GN ORFNames=CNAG_03319 {ECO:0000313|EMBL:AFR96540.2};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR96540.2, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR96540.2, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
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DR EMBL; CP003827; AFR96540.2; -; Genomic_DNA.
DR RefSeq; XP_012050913.1; XM_012195523.1.
DR AlphaFoldDB; J9VXV8; -.
DR GeneID; 23886831; -.
DR KEGG; cng:CNAG_03319; -.
DR VEuPathDB; FungiDB:CNAG_03319; -.
DR HOGENOM; CLU_007858_0_0_1; -.
DR OrthoDB; 164125at2759; -.
DR Proteomes; UP000010091; Chromosome 8.
DR CDD; cd13316; PH_Boi; 1.
DR CDD; cd09535; SAM_BOI-like_fungal; 1.
DR CDD; cd00174; SH3; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24216:SF65; PAXILLIN-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR24216; PAXILLIN-RELATED; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..63
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 388..452
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 709..821
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 44..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 844..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..968
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..80
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..123
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..610
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..633
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..892
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..926
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1087 AA; 112735 MW; F9F3212918D47D4E CRC64;
MALTVRAIHT FVAEHGDELD FHAGDHIVVL EKDEAFGDGW WRGRNPKGEE GLFPATYISE
SPEPASPASP ATPAKTETPP APAENPVNGK QPSTKQPSIH TQTPPAAIPA PTPTPPLPQA
DDPAPGAWPA DNSLAVPDIP IPNESPKGTT DAQGGILESA TASAGAAAAN VGNVMNRTIG
DIQDAIESYA RPESDDEHEH AELGIGQDAR AKLVEQARLA NEKRERDETG FVYSDESEDE
EEDFGKGLPL VTKSRTSIVS IGTESQDVNG FHDEPVETLP AEPKTIEPAL IPAPIVATST
AAATVPGPAA TPKPEPELTP LVPTSSDQRE PSVGTLQPAF IPATPPLVQT PTTLGAITPT
PLAQNAAAPP SSTSNRSSSI PAKPPTSWTV DDVVSWAQAK GFDDSICDKF REHEISGDVL
LELDANLLKE LDIPAFGKRM RIAAAIAELR RPSSMVSSSS QQFSPSGLPT HMSPGVSLRG
MSAPPSSYSV GVGASQPFPS TPPLSTPPMP SHSEEQGAYG AWAHHPRKHS GSAHTAPLIM
ESINESGSQP QPQTQAQPAV NKTTSNRSSQ PPPSSNTASS SVRATSTTTA ASTPVSPVTA
AGSTVTKRDS LGSLGHKRGK PSVDSKDRLS FFGRNRKPPA PLAGAGAAGA GSPTTGEHQQ
GMRSSSSRLG FGSSKVHQMQ PASPQNKRVS GPTPIAVSTG GAALKQIGTP DHAGYLKKKG
ERYGGWKSRY VVLKGSTLYI LKSEHADSLK DRIDLLHTHR IMADENANPG SYGFRLAAST
GAGGAAGAAG GAGGGAKSHS FSSSEQTVVR GWMKALLKAT IARDYTKPIT SSCNIPTIPL
AEAQALAPRP PSPATRAAMQ RATRRENPNQ LTPHDANILM SLDTTSGEKR RASQNLGVGA
SPARPSRDMR RPSSNFSQNT QKPASNAGAG VGAGAGADGV APLGAAAAPV TSQTSSGGAP
GAPSNVSTSE APQLLEWVNT HLPATYPRTT LSLPESFVSG EIIFSLVKSL SGVEPSPPVS
PAAFEREADG QPGLGGLIAM MDMLVDAGVK IDGISINEVR VGDKNGVVRL LKSVQDWYES
GQAGVQS
//
