ID J9VY61_CRYNH Unreviewed; 421 AA.
AC J9VY61;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=GDP-mannose transporter {ECO:0000256|RuleBase:RU367097};
DE Short=GMT {ECO:0000256|RuleBase:RU367097};
GN ORFNames=CNAG_03426 {ECO:0000313|EMBL:AFR96650.1};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR96650.1, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR96650.1, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
CC -!- FUNCTION: Involved in the import of GDP-mannose from the cytoplasm into
CC the Golgi lumen. {ECO:0000256|RuleBase:RU367097}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000256|RuleBase:RU367097}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004439, ECO:0000256|RuleBase:RU367097}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004439,
CC ECO:0000256|RuleBase:RU367097}. Golgi apparatus membrane
CC {ECO:0000256|RuleBase:RU367097}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU367097}. Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU367097}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU367097}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35D subfamily.
CC {ECO:0000256|ARBA:ARBA00010425, ECO:0000256|RuleBase:RU367097}.
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DR EMBL; CP003827; AFR96650.1; -; Genomic_DNA.
DR RefSeq; XP_012051249.1; XM_012195859.1.
DR AlphaFoldDB; J9VY61; -.
DR GeneID; 23886934; -.
DR KEGG; cng:CNAG_03426; -.
DR VEuPathDB; FungiDB:CNAG_03426; -.
DR HOGENOM; CLU_025360_1_2_1; -.
DR OrthoDB; 315146at2759; -.
DR Proteomes; UP000010091; Chromosome 8.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-UniRule.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR013657; SCL35B1-4/HUT1.
DR NCBIfam; TIGR00803; nst; 1.
DR PANTHER; PTHR11132; SOLUTE CARRIER FAMILY 35; 1.
DR PANTHER; PTHR11132:SF258; TRANSMEMBRANE PROTEIN 241; 1.
DR Pfam; PF08449; UAA; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|RuleBase:RU367097};
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU367097};
KW Golgi apparatus {ECO:0000256|RuleBase:RU367097};
KW Membrane {ECO:0000256|RuleBase:RU367097};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597,
KW ECO:0000256|RuleBase:RU367097};
KW Transmembrane {ECO:0000256|RuleBase:RU367097};
KW Transmembrane helix {ECO:0000256|RuleBase:RU367097};
KW Transport {ECO:0000256|RuleBase:RU367097}.
FT TRANSMEM 81..102
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367097"
FT TRANSMEM 108..127
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367097"
FT TRANSMEM 147..163
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367097"
FT TRANSMEM 169..188
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367097"
FT TRANSMEM 200..218
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367097"
FT TRANSMEM 255..273
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367097"
FT TRANSMEM 294..313
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367097"
FT TRANSMEM 325..349
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367097"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367097"
FT TRANSMEM 382..401
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367097"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 421 AA; 45309 MW; 1CF774F32293166C CRC64;
MASYTPSSSR PHTPLGLSPR GSYTNLASAA AYDASSPGGH GAKDEKERLR AEREVQEALL
KAQDGVEKAK KEEACMPAST TVLPILSYCV ASIMMTVVNK FVVSGRQFTM TFLLLAIQSF
VCVACVWSAK RIGIINFRDW DMNDAKAWFP VSSLLVAVIY TGSKSLQFLS IPVYTIFKNL
TIILIAYGEV IWFGGHVTPL TLCSFFLMVG SSVIAAWADI STTLSKLSAG VAVVDPISGA
DVPLSSISVL DTMNVGYLWM FINCLASAGY VLFMRKRIKV TGFKDWDSMF YNNLLSIPVL
FIFSLVIEDW GAASFSRNFP EEGRVFLLSA IAFSGAAAVF ISYSTAWCVR ICGATTYSLV
GALNKLPVAA SGILFFGDPM NFGNVSAILV GGVSGIVYAV AKTNQAKVEK SKQARGGDSK
A
//
