ID J9VZU6_CRYNH Unreviewed; 1285 AA.
AC J9VZU6;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Pre-rRNA-processing protein fhl1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=CNAG_05535 {ECO:0000313|EMBL:AFR98961.1};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR98961.1, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR98961.1, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR EMBL; CP003833; AFR98961.1; -; Genomic_DNA.
DR RefSeq; XP_012053835.1; XM_012198445.1.
DR GeneID; 23888839; -.
DR KEGG; cng:CNAG_05535; -.
DR VEuPathDB; FungiDB:CNAG_05535; -.
DR HOGENOM; CLU_262723_0_0_1; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000010091; Chromosome 14.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd00059; FH_FOX; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11829:SF343; FORK HEAD DOMAIN TRANSCRIPTION FACTOR SLP1-RELATED; 1.
DR PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
FT DOMAIN 158..205
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 731..828
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 731..828
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 57..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1038..1125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1195..1285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..81
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..343
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..367
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..485
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..589
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..664
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..862
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1057..1075
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1285 AA; 135790 MW; 03DB78EA2F08E01E CRC64;
MSHHPPAPSL AALPVDTSKT DPTPAYYKLQ FGDDLTGFSY YVRTLTVVIG RNCERPAPVP
PPAITSPSVP TNPPLDPNEP SPPGLCTGGI LRTPPVASFN SPSVVEEDHE VNLEDYGPLV
ELAEAVAVKE EDVADDISPV LELPDAPPPP PPPKSSANVE HVDVDLGPLK SVSRNHAKIE
YRSELGRFCL EILGRNGAWI DDRYYVKGAV VPLAQGSQIQ IATRIFSFVL PPSSVPSPPY
NYYDKSALEN VENLPYPYNL PASEVRYQEF FGEAGPGPAT AAAMASRQPP AFNAFAAADG
YGLGLGVDVE SQWGQWESEE ESDSDVERDH EQSFERDSEK DAHEEEQAED EDWDDAQSED
EDEDEYEEAK PKQATKIKLK KPLVVPGEDE SDLSSLESEP AKPLKSVKKQ AGKKQSQSQS
KSVENEKVKA PKDAKKPSKK ESKSKKKIKE PTPPVEESPA EVKGTPSKSK KKEKEKEKNK
IDSLAEQKQE IQAVTSDEKE KATPQKKDQK KKIKPASESK PLVKPAPGLK LPIPLAQQQQ
QHQPATQPQP PSVPTLAAAL ANTPTPPTIA PTPTSQPVVR PPQQPVRPVP GQPQQGIVRP
PGVSGQPGQP MIRPGQPGVP MGVRPPVSGS GQIPVRPGQP HSHLKQPLPS TPGVRPPLPQ
TPVPRTTPSS AGTTPQPTQP FFCTELKESS GRPGHIIVNV PIPPSGAGPR PPPGPILGLD
GKPFIGPPPL KPTSTFATII HKALSCLPRG RGTLGEVCNW VAGEWEWFRL NVDSGWQNSI
RHNLSLNKAF LKVPRIPEDD PESKGSVWII DPQEGPLFEE KQRRDAMKSA SKDKNAESRR
EKERIRAEER AKKQREAAIE AARNPHAHPS YVHHPHPTMA RAMPPMATAR AIARPPANVA
HPHPQPSTTQ PVPNQPTSAN IKGVLQPKAK ITVVMQPITP ALRAKSVIAN TDSNGNPLPF
VCDGTTLVLD QSTFGHLTSD ILDKLTLLGA AGAVDVLSAW VINKNKMQAS KAAQQAKTGA
TGTATTSGAA PGVVGAKNGV VNGAARPTNG VQPARPQPQV APKPNTTPAA RPAIPPKPAA
ASAASAAPTA TVTTTPAQPA PSTTPAVKPA SSNPPKSLPG PAPPGTSLTK VIGMIAAVAN
AKGDVNTVGP NASALLRYIR VVGVEIDLRV AERIWATGVV PPLPVKKVAK PVSGAATGSA
SVGGAKPTQG AGVKPQGQLQ GGAKPMQNAS VPAPAPSAAG VAGMKRKLED GAQGQGLERG
NSNGAGGGTG GDQEAKKPRL ETSSV
//
