ID J9W3M1_CRYNH Unreviewed; 281 AA.
AC J9W3M1;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:AFR98805.1, ECO:0000313|EMBL:AGV14848.1};
GN ORFNames=CNAG_05378 {ECO:0000313|EMBL:AFR98805.1};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR98805.1, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR98805.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H99 {ECO:0000313|EMBL:AFR98805.1};
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Cuomo C., Gargeya S., Jaffe D., Young S.K., Wortman J., Zeng Q.,
RA Alvarado L., Dietrich F., Allen A., Stajich J.E., Heitman J., Kronstad J.;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AFR98805.1, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 {ECO:0000313|EMBL:AFR98805.1}, and H99 / ATCC 208821 / CBS
RC 10515 / FGSC 9487 {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
RN [3] {ECO:0000313|EMBL:AFR98805.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H99 {ECO:0000313|EMBL:AFR98805.1};
RG The Broad Institute Genomics Platform;
RA Cuomo C., Janbon G.J., Paulet D., Neuveglise C., Dietrich F., Allen A.,
RA Stajich J.S., Heitman J., Kronstad J., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M.D., Poon T., Priest M., Roberts A.D., Saif S., Shea T.D.,
RA Sykes S.N., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Cryptococcus neoformans grubii H99.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR EMBL; CP003833; AFR98805.1; -; Genomic_DNA.
DR EMBL; CP003833; AGV14848.1; -; Genomic_DNA.
DR RefSeq; XP_012053724.1; XM_012198334.1.
DR RefSeq; XP_012053725.1; XM_012198335.1.
DR AlphaFoldDB; J9W3M1; -.
DR GeneID; 23888697; -.
DR KEGG; cng:CNAG_05378; -.
DR VEuPathDB; FungiDB:CNAG_05378; -.
DR HOGENOM; CLU_010194_42_2_1; -.
DR OrthoDB; 149879at2759; -.
DR Proteomes; UP000010091; Chromosome 14.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43658:SF8; 3-HYDROXYACYL-COA DEHYDROGENASE TYPE-2; 1.
DR PANTHER; PTHR43658; SHORT-CHAIN DEHYDROGENASE/REDUCTASE; 1.
DR Pfam; PF13561; adh_short_C2; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
SQ SEQUENCE 281 AA; 30028 MW; 26ED5BF6E6169385 CRC64;
MKLEGKAFVI TGGCGSIGGT TAKQIIARGG IALIFDVLPE EAGQAKVKEY HPERAFYFKA
DITDVDVFSA CIDAALKVIP KGSLFGGVHC AAIAPGRPWD HKLKNSIAHF QKVMHVNAYG
TFLVDSCIAD AINSQYPDEG PFGARVKEER GCIVNIASVV AKPVPARCLT YGVSKTAVLG
ITSGIADFLG PYGIRVNSVC PAVVASALMG PDRIPYFESE LEAAAIFPRR TSQPEEVAQG
IVYLLENSMM NDFELRIDGG WRGSSNWGGP HDPRSNAPSL E
//
