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Database: UniProt
Entry: J9YZE1_9PROT
LinkDB: J9YZE1_9PROT
Original site: J9YZE1_9PROT 
ID   J9YZE1_9PROT            Unreviewed;       950 AA.
AC   J9YZE1;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   28-FEB-2018, entry version 21.
DE   SubName: Full=2-oxoglutarate dehydrogenase, E1 component {ECO:0000313|EMBL:AFS48467.1};
DE            EC=1.2.4.2 {ECO:0000313|EMBL:AFS48467.1};
GN   ORFNames=HIMB59_00002640 {ECO:0000313|EMBL:AFS48467.1};
OS   alpha proteobacterium HIMB59.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Pelagibacterales;
OC   Pelagibacteraceae.
OX   NCBI_TaxID=744985 {ECO:0000313|EMBL:AFS48467.1, ECO:0000313|Proteomes:UP000006097};
RN   [1] {ECO:0000313|EMBL:AFS48467.1, ECO:0000313|Proteomes:UP000006097}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HIMB59 {ECO:0000313|EMBL:AFS48467.1,
RC   ECO:0000313|Proteomes:UP000006097};
RA   Grote J., Thrash C., Huggett M.J., Landry Z., Carini P.,
RA   Giovannoni S.J., Rappe M.S., Brinkac L., Kim M., Beeson K.,
RA   Ferriera S., Sutton G., Friedman R., Venter J.C.;
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP003801; AFS48467.1; -; Genomic_DNA.
DR   RefSeq; WP_014954298.1; NC_018644.1.
DR   ProteinModelPortal; J9YZE1; -.
DR   EnsemblBacteria; AFS48467; AFS48467; HIMB59_00002640.
DR   KEGG; apc:HIMB59_00002640; -.
DR   PATRIC; fig|744985.3.peg.264; -.
DR   KO; K00164; -.
DR   OrthoDB; POG091H03SK; -.
DR   BioCyc; APRO744985:G1HAF-259-MONOMER; -.
DR   Proteomes; UP000006097; Chromosome.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   PANTHER; PTHR23152; PTHR23152; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   TIGRFAMs; TIGR00239; 2oxo_dh_E1; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006097};
KW   Oxidoreductase {ECO:0000313|EMBL:AFS48467.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006097}.
FT   DOMAIN      586    779       Transket_pyr. {ECO:0000259|SMART:
FT                                SM00861}.
SQ   SEQUENCE   950 AA;  108125 MW;  1337C4F80B2634B6 CRC64;
     MRSYNSFLTA NNASQIISIY KDFVKNPSSV DQSWHNFFKE LAPEELAILA DYEKLDWSKK
     ARSSDFSQTS LNQAISDSLR LVMMIRAYRE IGHLIANLDP LNLAVQSKPA GLDPEYYGFQ
     EKDLDRKIFL FGYLGFETAS VRQVFDKLQK IYSGTLSIEY KHIQSAEEYL WLKDRIEDRK
     DMQLTPRGKR TILERLISAE YFEKFLDTKY RGTKRFGLDG AESTIPALEQ ILKRSSEYGI
     EDFSFACAHR GRLNILANVV KKPHIQIFSE FIHGGENALS NEGSGDVKYH LGASSDRSFS
     GNLIHVSMAA NPSHLEAVNP VVAGKIRAKQ ALVGDKNNEK VSGLLIHGDA AIAGQGVVAE
     TFTMSQLNGY RIGGLIHFII NNQIGFTTAP QYSRSAPYSS EIGKIVQAPI FHVNGDDPEA
     VVLASRAATE FRNSFKKDTL VDMFCYRKHG HNEGDEPSFT QPLMYQTIKK KKPVAEIYAQ
     KLIEQEVLNS KQVEYIKDAV WSDLEKKFEK AKNYKLKTKS WMGGQWSGLS RAPKDTLRRG
     RTAEPTKSLQ DIGKKITQVP KDFNLHPKLE KFNSSRLKAI QSGKNIDWAF AEALAFGSLL
     KEGFKVRLAG QDSGRGTFSQ RHSVFYDQKT EERYIPLNHI AKKQKQFEVI DSFLSEMGVL
     GFEYGYSLAD PNSLVIWEAQ FGDFANGAQI IIDQFIAASE RKWMQMSGLV MLLPHGHEGM
     GPEHSSARIE RFLQMAAEDN IQILNCTTPA SYFHALRRQI HRNFRKPLII FTPKSTLRHP
     NNVSNIEDFT GRSAFHRIID EDIKNPKRVV FCSGKIFYEL DDYRKENKIK DVKIVRLEQI
     YPFPFDTLGE VILKHKDAEM LWVQEEPKNM GAWAFVKSRI RHLFKKHDLE KNLHYVGRRR
     AAAPATGIAK RHNANQNLIK KLALHSPLKS VIKEKIGVSF IKFKNLPTNE
//
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