ID   J9Z2P0_9PROT            Unreviewed;       164 AA.
AC   J9Z2P0;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   SubName: Full=Na+/H+ ion antiporter subunit {ECO:0000313|EMBL:AFS49555.1};
DE   Flags: Precursor;
GN   ORFNames=HIMB59_00013790 {ECO:0000313|EMBL:AFS49555.1};
OS   alpha proteobacterium HIMB59.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Candidatus Pelagibacterales;
OC   Candidatus Pelagibacteraceae.
OX   NCBI_TaxID=744985 {ECO:0000313|EMBL:AFS49555.1, ECO:0000313|Proteomes:UP000006097};
RN   [1] {ECO:0000313|EMBL:AFS49555.1, ECO:0000313|Proteomes:UP000006097}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HIMB59 {ECO:0000313|EMBL:AFS49555.1,
RC   ECO:0000313|Proteomes:UP000006097};
RA   Grote J., Thrash C., Huggett M.J., Landry Z., Carini P., Giovannoni S.J.,
RA   Rappe M.S., Brinkac L., Kim M., Beeson K., Ferriera S., Sutton G.,
RA   Friedman R., Venter J.C.;
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E
CC       family. {ECO:0000256|ARBA:ARBA00006228}.
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DR   EMBL; CP003801; AFS49555.1; -; Genomic_DNA.
DR   AlphaFoldDB; J9Z2P0; -.
DR   STRING; 744985.HIMB59_00013790; -.
DR   KEGG; apc:HIMB59_00013790; -.
DR   PATRIC; fig|744985.3.peg.1362; -.
DR   eggNOG; COG1863; Bacteria.
DR   HOGENOM; CLU_086615_2_0_5; -.
DR   OrthoDB; 9807187at2; -.
DR   Proteomes; UP000006097; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR002758; Cation_antiport_E.
DR   PANTHER; PTHR34584; NA(+)/H(+) ANTIPORTER SUBUNIT E1; 1.
DR   PANTHER; PTHR34584:SF1; NA(+)_H(+) ANTIPORTER SUBUNIT E1; 1.
DR   Pfam; PF01899; MNHE; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006097};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        34..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   164 AA;  18548 MW;  D39840F450FF7CA5 CRC64;
     MANKTINSVK FLSILVYFLV LFALWYVLSG YLKPLLLFFG LVSVLFVSWM SLRAKALDND
     ALPLKLLLRL PFYWLWLVKE IFKSGITTTK IIWNNKPSPE LIKIKASQKN STGIANYANA
     ITLTPGTVTI EVEKNDLLIH ALSKELSEDL QTGEMDRLIS GLDK
//